Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIM6
  • Mouse genes Trim6
  • Rat genes Trim6
  • Zfish genes si:ch211-114c12.5,si:ch211-120g10.1,si:ch73-364h19.2,si:dkey-18p12.4,si:dkey-219e21.2,zgc:194990
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trim6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Trim6	IPI	UniProtKB:P01108	Mouse	MGI:MGI:5492022|PMID:22328504
Molecular Function	GO:0042802	identical protein binding	TRIM6	IPI	UniProtKB:Q9C030	Human	PMID:17156811
Molecular Function	GO:0005515	protein binding	TRIM6	IPI	UniProtKB:Q14457	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	Trim6	IPI	PR:Q8BGE7	Mouse	PMID:11331580
Molecular Function	GO:0019901	protein kinase binding	TRIM6	IPI	UniProtKB:Q14164	Human	PMID:24882218
Molecular Function	GO:0019901	protein kinase binding	TRIM6	IPI	UniProtKB:O75385	Human	PMID:25127057
Molecular Function	GO:0019901	protein kinase binding	Trim6	IPI	UniProtKB:Q9R0T8	Mouse	MGI:MGI:5645191|PMID:24882218
Molecular Function	GO:1990782	protein tyrosine kinase binding	TRIM6	IPI	UniProtKB:P23458	Human	PMID:24882218
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	TRIM6	IPI	UniProtKB:O75385|UniProtKB:Q14457	Human	PMID:25127057
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM6	IMP	UniProtKB:Q9C030	Human	PMID:24882218
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM6	IDA		Human	PMID:28679761
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM6	IDA		Human	PMID:35263596
Cellular Component	GO:0005737	cytoplasm	TRIM6	IDA		Human	PMID:35263596
Cellular Component	GO:0005737	cytoplasm	TRIM6	IDA		Human	PMID:17156811
Cellular Component	GO:0005737	cytoplasm	TRIM6	IDA		Human	PMID:24882218
Cellular Component	GO:0005737	cytoplasm	Trim6	IDA		Mouse	PMID:11331580
Cellular Component	GO:0005829	cytosol	Trim6	IMP		Mouse	MGI:MGI:5492022|PMID:22328504
Cellular Component	GO:0005634	nucleus	Trim6	IMP		Mouse	MGI:MGI:5492022|PMID:22328504
Biological Process	GO:0140374	antiviral innate immune response	TRIM6	IDA		Human	PMID:35263596
Biological Process	GO:0035458	cellular response to interferon-beta	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0098586	cellular response to virus	Trim6	IDA		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0010994	free ubiquitin chain polymerization	TRIM6	IMP	UniProtKB:P61086	Human	PMID:24882218
Biological Process	GO:0010994	free ubiquitin chain polymerization	TRIM6	IDA		Human	PMID:35263596
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Trim6	IDA		Mouse	MGI:MGI:5492022|PMID:22328504
Biological Process	GO:0010629	negative regulation of gene expression	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:2000737	negative regulation of stem cell differentiation	Trim6	IMP		Mouse	MGI:MGI:5492022|PMID:22328504
Biological Process	GO:0045071	negative regulation of viral genome replication	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0045071	negative regulation of viral genome replication	Trim6	IMP		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0002230	positive regulation of defense response to virus by host	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0010628	positive regulation of gene expression	Trim6	IMP	UniProtKB:Q9R0T8	Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0010628	positive regulation of gene expression	Trim6	IMP		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0010628	positive regulation of gene expression	Trim6	IMP		Mouse	MGI:MGI:5492022|PMID:22328504
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	TRIM6	IDA		Human	PMID:24882218
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	TRIM6	IMP		Human	PMID:24882218
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Trim6	IMP		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0070936	protein K48-linked ubiquitination	TRIM6	IDA		Human	PMID:24882218
Biological Process	GO:0000209	protein polyubiquitination	Trim6	IDA		Mouse	MGI:MGI:5492022|PMID:22328504
Biological Process	GO:0032496	response to lipopolysaccharide	TRIM6	IMP		Human	PMID:24882218

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern