Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIM65
  • Mouse genes Trim65
  • Rat genes Trim65
  • Zfish genes trim65
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trim65

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM65	IDA		Human	PMID:28594402
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM65	IDA		Human	PMID:31310649
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM65	IDA		Human	PMID:34512673
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Trim65	IDA		Mouse	PMID:28031478
Cellular Component	GO:0005737	cytoplasm	TRIM65	IDA		Human	PMID:34512673
Cellular Component	GO:0005737	cytoplasm	Trim65	IDA		Mouse	PMID:28031478
Cellular Component	GO:0005829	cytosol	TRIM65	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TRIM65	IDA		Human	GO_REF:0000052
Biological Process	GO:0140374	antiviral innate immune response	Trim65	IMP	MGI:MGI:6356826	Mouse	PMID:28031478
Biological Process	GO:0140374	antiviral innate immune response	Trim65	IMP	MGI:MGI:6356825	Mouse	PMID:28031478
Biological Process	GO:0140374	antiviral innate immune response	Trim65	IMP	MGI:MGI:6356827	Mouse	PMID:28031478
Biological Process	GO:0050728	negative regulation of inflammatory response	TRIM65	IDA		Human	PMID:31310649
Biological Process	GO:0050728	negative regulation of inflammatory response	TRIM65	IDA		Human	PMID:34512673
Biological Process	GO:0010508	positive regulation of autophagy	TRIM65	IMP		Human	PMID:26347139
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Trim65	IMP	MGI:MGI:6356827	Mouse	PMID:28031478
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Trim65	IMP	MGI:MGI:6356825	Mouse	PMID:28031478
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Trim65	IMP	MGI:MGI:6356826	Mouse	PMID:28031478
Biological Process	GO:0032728	positive regulation of interferon-beta production	TRIM65	IDA		Human	PMID:28594402
Biological Process	GO:0032728	positive regulation of interferon-beta production	Trim65	IMP	MGI:MGI:6356825	Mouse	PMID:28031478
Biological Process	GO:0032728	positive regulation of interferon-beta production	Trim65	IMP	MGI:MGI:6356827	Mouse	PMID:28031478
Biological Process	GO:0032728	positive regulation of interferon-beta production	Trim65	IMP	MGI:MGI:6356826	Mouse	PMID:28031478
Biological Process	GO:0032461	positive regulation of protein oligomerization	Trim65	IMP	MGI:MGI:6356825	Mouse	PMID:28031478
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Trim65	IMP	MGI:MGI:6356825	Mouse	PMID:28031478
Biological Process	GO:0070936	protein K48-linked ubiquitination	TRIM65	IDA		Human	PMID:31310649
Biological Process	GO:0070936	protein K48-linked ubiquitination	TRIM65	IDA		Human	PMID:34512673
Biological Process	GO:0070534	protein K63-linked ubiquitination	TRIM65	IDA		Human	PMID:28594402
Biological Process	GO:0070534	protein K63-linked ubiquitination	Trim65	IDA		Mouse	PMID:28031478
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Trim65	IMP	MGI:MGI:6356825	Mouse	PMID:28031478

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern