Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIM8
  • Mouse genes Trim8
  • Rat genes Trim8
  • Zfish genes trim8a,trim8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trim8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TRIM8	IPI	UniProtKB:Q9BZR9	Human	PMID:22493164
Molecular Function	GO:0042802	identical protein binding	TRIM8	IPI	UniProtKB:Q9BZR9	Human	PMID:22829933
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Trim8	IPI	RGD:1309438	Rat	PMID:27956576|RGD:155791649
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:O14933	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:P51668	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q9Y2X8	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:O14787-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:O14933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:O94888	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:P45974-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:P51668	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:P54725	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:P57075-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q17RB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q5VVQ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q63HR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q8IYW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q8N3F0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q8NEC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q8NFP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q96DC9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q96GG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q96KP6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q9H5Z6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q9Y2X8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRIM8	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Trim8	IPI	UniProtKB:O35716	Mouse	MGI:MGI:2387897|PMID:12163497
Molecular Function	GO:0005515	protein binding	Trim8	IPI	PR:P11499	Mouse	PMID:21689689
Molecular Function	GO:0005515	protein binding	Trim8	IPI	PR:Q99PJ2	Mouse	PMID:11331580
Molecular Function	GO:0042803	protein homodimerization activity	TRIM8	IPI	UniProtKB:Q9BZR9	Human	PMID:11331580
Molecular Function	GO:0003713	transcription coactivator activity	TRIM8	IDA		Human	PMID:23077300
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TRIM8	IDA		Human	PMID:27995356
Cellular Component	GO:0005737	cytoplasm	TRIM8	IDA		Human	PMID:23152791
Cellular Component	GO:0005829	cytosol	Trim8	IDA		Mouse	PMID:21689689
Cellular Component	GO:0005634	nucleus	TRIM8	IMP		Human	PMID:33508234
Cellular Component	GO:0005634	nucleus	Trim8	IDA		Mouse	PMID:11331580
Cellular Component	GO:0005634	nucleus	trim8b	IDA		Zfish	PMID:23118857
Cellular Component	GO:0005634	nucleus	trim8a	IDA		Zfish	PMID:23118857
Cellular Component	GO:0016605	PML body	TRIM8	IDA		Human	PMID:11331580
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	TRIM8	IDA		Human	PMID:27995356
Biological Process	GO:0045087	innate immune response	TRIM8	IDA		Human	PMID:18248090
Biological Process	GO:0045087	innate immune response	Trim8	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0046597	negative regulation of viral entry into host cell	Trim8	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0032897	negative regulation of viral transcription	Trim8	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0010508	positive regulation of autophagy	TRIM8	IMP		Human	PMID:26347139
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	TRIM8	IDA		Human	PMID:23077300
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TRIM8	IDA		Human	PMID:23077300
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TRIM8	IDA		Human	PMID:23077300
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	Trim8	IMP		Mouse	PMID:21689689
Biological Process	GO:0070534	protein K63-linked ubiquitination	TRIM8	IDA		Human	PMID:27995356
Biological Process	GO:0019827	stem cell population maintenance	Trim8	IMP		Mouse	PMID:21689689
Biological Process	GO:0044790	suppression of viral release by host	TRIM8	IDA		Human	PMID:18248090
Biological Process	GO:0044790	suppression of viral release by host	Trim8	IDA		Mouse	MGI:MGI:5545996|PMID:18248090

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern