Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TP53BP1
  • Mouse genes Trp53bp1
  • Rat genes Tp53bp1
  • Zfish genes tp53bp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trp53bp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	Trp53bp1	IDA		Mouse	PMID:11934988
Molecular Function	GO:0035064	methylated histone binding	TP53BP1	IDA		Human	PMID:22373579
Molecular Function	GO:0035064	methylated histone binding	TP53BP1	IDA		Human	PMID:23760478
Molecular Function	GO:0035064	methylated histone binding	TP53BP1	IDA		Human	PMID:27153538
Molecular Function	GO:0035064	methylated histone binding	TP53BP1	IDA		Human	PMID:28241136
Molecular Function	GO:0035064	methylated histone binding	Trp53bp1	IDA		Mouse	MGI:MGI:5887191|PMID:23209566
Molecular Function	GO:0002039	p53 binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:14985081
Molecular Function	GO:0002039	p53 binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:17805299
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:11877378
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16104	Human	PMID:12607005
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q6ZW49	Human	PMID:15456759
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P62805	Human	PMID:16415788
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P68431	Human	PMID:16415788
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q96RU2	Human	PMID:16901786
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16104	Human	PMID:17024177
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O43257	Human	PMID:17380123
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q6NZQ4	Human	PMID:17500065
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P38398	Human	PMID:17525332
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:17805299
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q6NZQ4	Human	PMID:17925232
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16104	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P38398	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16104	Human	PMID:18001825
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q6NZQ4	Human	PMID:19124460
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:19433796
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q14686	Human	PMID:19433796
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16104	Human	PMID:20075863
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P53350	Human	PMID:20126263
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q2TAK8	Human	PMID:20347427
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16104	Human	PMID:21317870
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P62805	Human	PMID:22373579
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q13315	Human	PMID:22621922
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q99986	Human	PMID:22621922
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:22653443
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P38398	Human	PMID:22884692
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q5UIP0	Human	PMID:23333306
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P62805	Human	PMID:23377543
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q08AM6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:25837623
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P62805	Human	PMID:27153538
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P62807	Human	PMID:27462807
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q5UIP0	Human	PMID:28241136
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q9BRJ7	Human	PMID:28241136
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P38398	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q13315	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q86V20	Human	PMID:29789392
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q86V20-2	Human	PMID:29789392
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P41182	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P78337	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q02930-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q49AR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q5SWW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q5T6F2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q8TDS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q96G42	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q96HB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P53350	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O75190-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P04275-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P08670	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P10809	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P13637	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P23763-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P61086	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q13393	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TP53BP1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	UniProtKB:P53350	Mouse	MGI:MGI:5915058|PMID:20126263
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	UniProtKB:Q6PR54	Mouse	MGI:MGI:5468036|PMID:23306439
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	UniProtKB:Q6PR54	Mouse	MGI:MGI:5468037|PMID:23306437
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	UniProtKB:Q6PR54	Mouse	MGI:MGI:5476381|PMID:23333305
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	MGI:MGI:1347080	Mouse	PMID:8910340
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	PR:P02340	Mouse	PMID:15364958
Molecular Function	GO:0005515	protein binding	Trp53bp1	IPI	PR:O88700	Mouse	PMID:15364958
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	TP53BP1	IPI	UniProtKB:P04637	Human	PMID:17805299
Molecular Function	GO:0043565	sequence-specific DNA binding	Trp53bp1	IDA		Mouse	PMID:23241889
Molecular Function	GO:0042162	telomeric DNA binding	Trp53bp1	IDA		Mouse	PMID:17053789
Molecular Function	GO:0003712	transcription coregulator activity	TP53BP1	IMP		Human	PMID:17805299
Molecular Function	GO:0061649	ubiquitin modification-dependent histone binding	TP53BP1	IDA		Human	PMID:22492721
Molecular Function	GO:0061649	ubiquitin modification-dependent histone binding	TP53BP1	IDA		Human	PMID:23760478
Molecular Function	GO:0061649	ubiquitin modification-dependent histone binding	TP53BP1	IDA		Human	PMID:27153538
Molecular Function	GO:0061649	ubiquitin modification-dependent histone binding	TP53BP1	IDA		Human	PMID:32209463
Cellular Component	GO:0000781	chromosome, telomeric region	TP53BP1	IDA		Human	PMID:15149599
Cellular Component	GO:0000781	chromosome, telomeric region	Trp53bp1	IDA		Mouse	PMID:19001091
Cellular Component	GO:0005737	cytoplasm	TP53BP1	IDA		Human	PMID:9748285
Cellular Component	GO:1990391	DNA repair complex	Trp53bp1	IDA		Mouse	PMID:24217620
Cellular Component	GO:0000776	kinetochore	Trp53bp1	IDA		Mouse	PMID:11801725
Cellular Component	GO:0016604	nuclear body	TP53BP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	Trp53bp1	IDA		Mouse	PMID:21746928
Cellular Component	GO:0005654	nucleoplasm	TP53BP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TP53BP1	IDA		Human	PMID:28241136
Cellular Component	GO:0005634	nucleus	Trp53bp1	IDA		Mouse	PMID:24001775
Cellular Component	GO:0005634	nucleus	Tp53bp1	IDA		Rat	PMID:22672902|RGD:9586750
Cellular Component	GO:0005657	replication fork	Trp53bp1	IDA		Mouse	PMID:15364958
Cellular Component	GO:0035861	site of double-strand break	TP53BP1	IDA		Human	PMID:22492721
Cellular Component	GO:0035861	site of double-strand break	TP53BP1	IDA		Human	PMID:27153538
Cellular Component	GO:0035861	site of double-strand break	TP53BP1	IDA		Human	PMID:32209463
Cellular Component	GO:0035861	site of double-strand break	TP53BP1	IDA		Human	PMID:23333306
Cellular Component	GO:0035861	site of double-strand break	TP53BP1	IDA		Human	PMID:23760478
Cellular Component	GO:0035861	site of double-strand break	TP53BP1	IDA		Human	PMID:28241136
Cellular Component	GO:0035861	site of double-strand break	Trp53bp1	IDA		Mouse	MGI:MGI:5476381|PMID:23333305
Cellular Component	GO:0035861	site of double-strand break	Trp53bp1	IDA		Mouse	MGI:MGI:5887191|PMID:23209566
Biological Process	GO:0071481	cellular response to X-ray	Tp53bp1	IEP		Rat	PMID:21915754|RGD:9586753
Biological Process	GO:0006974	DNA damage response	TP53BP1	IDA		Human	PMID:17500065
Biological Process	GO:0006974	DNA damage response	TP53BP1	IDA		Human	PMID:27153538
Biological Process	GO:0006974	DNA damage response	TP53BP1	IDA		Human	PMID:28241136
Biological Process	GO:0006281	DNA repair	Trp53bp1	IDA		Mouse	PMID:15364958
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	TP53BP1	IDA		Human	PMID:23333306
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	TP53BP1	IDA		Human	PMID:23760478
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	TP53BP1	IDA		Human	PMID:27153538
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	TP53BP1	IDA		Human	PMID:28241136
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Trp53bp1	IDA		Mouse	MGI:MGI:5887194|PMID:20362325
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Trp53bp1	IMP		Mouse	MGI:MGI:5476381|PMID:23333305
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	TP53BP1	IDA		Human	PMID:23333306
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	TP53BP1	IDA		Human	PMID:23345425
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	Trp53bp1	IDA		Mouse	MGI:MGI:5887194|PMID:20362325
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	Trp53bp1	IMP		Mouse	MGI:MGI:5476381|PMID:23333305
Biological Process	GO:0045830	positive regulation of isotype switching	TP53BP1	IDA		Human	PMID:23345425
Biological Process	GO:0045830	positive regulation of isotype switching	TP53BP1	IMP		Human	PMID:23760478
Biological Process	GO:0045830	positive regulation of isotype switching	Trp53bp1	IMP		Mouse	MGI:MGI:3041657|PMID:15077110
Biological Process	GO:0045830	positive regulation of isotype switching	Trp53bp1	IMP		Mouse	MGI:MGI:3046005|PMID:15159415
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP53BP1	IMP		Human	PMID:17805299
Biological Process	GO:0051260	protein homooligomerization	TP53BP1	IDA		Human	PMID:23345425

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern