Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Trp63

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TP63
- Mouse genes Trp63
- Rat genes Tp63
- Zfish genes tp63
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trp63

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Trp63	IDA		Mouse	PMID:16524929
Molecular Function	GO:0003684	damaged DNA binding	Trp63	IDA		Mouse	PMID:17122775
Molecular Function	GO:0003677	DNA binding	Trp63	IDA		Mouse	PMID:16363065
Molecular Function	GO:0003677	DNA binding	tp63	IPI	ZFIN:ZDB-GENE-070119-4	Zfish	PMID:21920315
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Trp63	IDA		Mouse	PMID:21930775
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TP63	IMP		Human	PMID:25417702
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tp63	IDA		Rat	PMID:11470269\|RGD:634449
Molecular Function	GO:0003690	double-stranded DNA binding	Tp63	IDA		Rat	PMID:11850815\|RGD:1600401
Molecular Function	GO:0042802	identical protein binding	TP63	IPI	UniProtKB:Q9H3D4	Human	PMID:10373484
Molecular Function	GO:0042802	identical protein binding	TP63	IPI	UniProtKB:Q9H3D4	Human	PMID:12446779
Molecular Function	GO:0042802	identical protein binding	TP63	IPI	UniProtKB:Q9H3D4	Human	PMID:19815500
Molecular Function	GO:0042802	identical protein binding	TP63	IPI	UniProtKB:Q9H3D4	Human	PMID:21335238
Molecular Function	GO:0042802	identical protein binding	TP63	IPI	UniProtKB:Q9H3D4	Human	PMID:21464285
Molecular Function	GO:0042802	identical protein binding	Trp63	IPI	UniProtKB:O88898\|UniProtKB:O88898-1\|UniProtKB:O88898-2\|UniProtKB:O88898-5	Mouse	MGI:MGI:5298329\|PMID:21335238
Molecular Function	GO:0042802	identical protein binding	Trp63	IPI	UniProtKB:O88898-2	Mouse	MGI:MGI:5512940\|PMID:22575646
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	TP63	IPI	UniProtKB:Q00987	Human	PMID:25417702
Molecular Function	GO:0002039	p53 binding	TP63	IPI	UniProtKB:P04637	Human	PMID:25417702
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P46937	Human	PMID:11278685
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q99729	Human	PMID:12692135
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q13625	Human	PMID:14729977
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q96KQ4	Human	PMID:14729977
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q96J02	Human	PMID:16908849
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q13625	Human	PMID:18275817
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P04637	Human	PMID:19345189
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q15796	Human	PMID:19345189
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:O15350	Human	PMID:19815500
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P35637	Human	PMID:20085233
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P61978	Human	PMID:20085233
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q99729	Human	PMID:20085233
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q9H2X6	Human	PMID:21602882
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P04637	Human	PMID:21741598
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q15796	Human	PMID:21741598
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q9UFN0	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:O15350	Human	PMID:22252508
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q05655	Human	PMID:26112605
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P57075-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q96EZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q96FA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:Q9HAT8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TP63	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Trp63	IPI	UniProtKB:P04637	Mouse	MGI:MGI:4430704\|PMID:19345189
Molecular Function	GO:0005515	protein binding	Trp63	IPI	UniProtKB:Q92831	Mouse	MGI:MGI:5512940\|PMID:22575646
Molecular Function	GO:0005515	protein binding	Trp63	IPI	UniProtKB:Q9ESJ1	Mouse	MGI:MGI:4888098\|PMID:20559324
Molecular Function	GO:0005515	protein binding	Trp63	IPI	PR:Q9R1E0	Mouse	PMID:23906066
Molecular Function	GO:0019904	protein domain specific binding	Tp63	IPI	RGD:3044	Rat	PMID:15623521\|RGD:1625439
Molecular Function	GO:0043565	sequence-specific DNA binding	Trp63	IDA		Mouse	PMID:18256694
Molecular Function	GO:0050699	WW domain binding	TP63	IPI	UniProtKB:Q6ZWJ1	Human	PMID:19451233
Cellular Component	GO:0000785	chromatin	TP63	IDA		Human	PMID:22521434
Cellular Component	GO:0005737	cytoplasm	TP63	IDA		Human	PMID:10657951
Cellular Component	GO:0030425	dendrite	Tp63	IDA		Rat	PMID:15623521\|RGD:1625439
Cellular Component	GO:0043005	neuron projection	Tp63	IDA		Rat	PMID:15623521\|RGD:1625439
Cellular Component	GO:0005654	nucleoplasm	TP63	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TP63	IDA		Human	PMID:10657951
Cellular Component	GO:0005634	nucleus	TP63	IDA		Human	PMID:11106548
Cellular Component	GO:0005634	nucleus	TP63	IDA		Human	PMID:12446779
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:18326838
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:23608756
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:21285247
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:12368184
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:17522155
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:17383628
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:15361520
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:15585950
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:11522642
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:18159078
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:16466397
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:14729569
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:16080917
Cellular Component	GO:0005634	nucleus	Trp63	IDA		Mouse	PMID:11106548
Cellular Component	GO:0005634	nucleus	Tp63	IDA		Rat	PMID:11850815\|RGD:1600401
Cellular Component	GO:0005634	nucleus	Tp63	IDA		Rat	PMID:15623521\|RGD:1625439
Cellular Component	GO:0005634	nucleus	tp63	IDA		Zfish	PMID:19757382
Cellular Component	GO:0032991	protein-containing complex	Tp63	IDA		Rat	PMID:15623521\|RGD:1625439
Cellular Component	GO:0005791	rough endoplasmic reticulum	Tp63	IDA		Rat	PMID:15623521\|RGD:1625439
Biological Process	GO:0007568	aging	Tp63	IEP		Rat	PMID:15316140\|RGD:11568653
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Trp63	IMP	MGI:MGI:1861713	Mouse	PMID:17878916
Biological Process	GO:0009887	animal organ morphogenesis	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:10227294
Biological Process	GO:0090398	cellular senescence	Trp63	IMP	MGI:MGI:2385473	Mouse	PMID:16107615
Biological Process	GO:0007417	central nervous system development	tp63	IGI		Zfish	PMID:15532058
Biological Process	GO:0006338	chromatin remodeling	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:21930775
Biological Process	GO:0060197	cloacal septation	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:12368184
Biological Process	GO:1904888	cranial skeletal system development	Trp63	IMP	MGI:MGI:5882553	Mouse	PMID:25503409
Biological Process	GO:1904888	cranial skeletal system development	Trp63	IMP	MGI:MGI:5882555	Mouse	PMID:25503409
Biological Process	GO:0008340	determination of adult lifespan	Trp63	IMP	MGI:MGI:2385473	Mouse	PMID:16107615
Biological Process	GO:0007499	ectoderm and mesoderm interaction	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:10227293
Biological Process	GO:0007499	ectoderm and mesoderm interaction	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:10227294
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Trp63	IMP	MGI:MGI:5882553	Mouse	PMID:25503409
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Trp63	IMP	MGI:MGI:5882555	Mouse	PMID:25503409
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Trp63	IMP	MGI:MGI:5882553	Mouse	PMID:25503409
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Trp63	IMP	MGI:MGI:5882555	Mouse	PMID:25503409
Biological Process	GO:0030326	embryonic limb morphogenesis	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:10227293
Biological Process	GO:0030326	embryonic limb morphogenesis	Trp63	IGI	MGI:MGI:101927	Mouse	PMID:18326838
Biological Process	GO:0030326	embryonic limb morphogenesis	Trp63	IGI	MGI:MGI:101926	Mouse	PMID:18326838
Biological Process	GO:0009913	epidermal cell differentiation	Trp63	IMP	MGI:MGI:5882555	Mouse	PMID:25503409
Biological Process	GO:0010481	epidermal cell division	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:21127502
Biological Process	GO:0008544	epidermis development	Trp63	IMP	MGI:MGI:5140823	Mouse	PMID:22274697
Biological Process	GO:0008544	epidermis development	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:10227293
Biological Process	GO:0048730	epidermis morphogenesis	tp63	IMP	ZFIN:ZDB-GENO-100528-7	Zfish	PMID:24415949
Biological Process	GO:0002064	epithelial cell development	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:21127502
Biological Process	GO:0030855	epithelial cell differentiation	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:12368184
Biological Process	GO:0030855	epithelial cell differentiation	Trp63	IMP	MGI:MGI:1861713	Mouse	PMID:17878916
Biological Process	GO:0001736	establishment of planar polarity	Trp63	IDA		Mouse	PMID:14729569
Biological Process	GO:0061436	establishment of skin barrier	Trp63	IMP		Mouse	MGI:MGI:5529391\|PMID:24075906
Biological Process	GO:0048807	female genitalia morphogenesis	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:12368184
Biological Process	GO:0001942	hair follicle development	Trp63	IMP	MGI:MGI:5882553	Mouse	PMID:25503409
Biological Process	GO:0001942	hair follicle development	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:16410075
Biological Process	GO:0031069	hair follicle morphogenesis	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:16524929
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:17122775
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	tp63	IMP	ZFIN:ZDB-MRPHLNO-050204-4	Zfish	PMID:21920315
Biological Process	GO:0030216	keratinocyte differentiation	Trp63	IDA		Mouse	PMID:14729569
Biological Process	GO:0043616	keratinocyte proliferation	Trp63	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0001738	morphogenesis of a polarized epithelium	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:15189821
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TP63	IDA		Human	PMID:12446784
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	tp63	IDA		Zfish	PMID:12015968
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Trp63	IMP		Mouse	MGI:MGI:5634223\|PMID:25655704
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	Trp63	IMP	MGI:MGI:5140823	Mouse	PMID:22274697
Biological Process	GO:2000381	negative regulation of mesoderm development	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:21127502
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Trp63	IDA		Mouse	PMID:23906066
Biological Process	GO:0051402	neuron apoptotic process	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:16337913
Biological Process	GO:0007219	Notch signaling pathway	Trp63	IMP	MGI:MGI:5140823	Mouse	PMID:22274697
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:16410075
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:16524929
Biological Process	GO:0007389	pattern specification process	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:10227294
Biological Process	GO:0030859	polarized epithelial cell differentiation	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:15189821
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Trp63	IDA		Mouse	PMID:9774969
Biological Process	GO:0008284	positive regulation of cell population proliferation	Tp63	IMP		Rat	PMID:11850815\|RGD:1600401
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TP63	IDA		Human	PMID:12446784
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TP63	IDA		Human	PMID:16343436
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TP63	IMP		Human	PMID:25417702
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	TP63	IDA		Human	PMID:9774969
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	Trp63	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	TP63	IDA		Human	PMID:11641404
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Trp63	IMP	MGI:MGI:5140823	Mouse	PMID:22274697
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	TP63	IMP		Human	PMID:22521434
Biological Process	GO:1904674	positive regulation of somatic stem cell population maintenance	Trp63	IMP		Mouse	MGI:MGI:5634223\|PMID:25655704
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Trp63	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP63	IDA		Human	PMID:22521434
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IDA		Mouse	PMID:21285247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IDA		Mouse	PMID:9774969
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IDA		Mouse	PMID:21930775
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IMP	MGI:MGI:3795257	Mouse	PMID:18326838
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IMP		Mouse	PMID:18256694
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IDA		Mouse	PMID:23906066
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Trp63	IMP	MGI:MGI:1861713	Mouse	PMID:15982302
Biological Process	GO:0036342	post-anal tail morphogenesis	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:12368184
Biological Process	GO:0030850	prostate gland development	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:11106548
Biological Process	GO:0060513	prostatic bud formation	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:11106548
Biological Process	GO:0009954	proximal/distal pattern formation	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:10227293
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:18159078
Biological Process	GO:0042665	regulation of ectodermal cell fate specification	tp63	IMP	ZFIN:ZDB-GENO-200616-1	Zfish	PMID:31296872
Biological Process	GO:0010482	regulation of epidermal cell division	Trp63	IMP		Mouse	MGI:MGI:5529391\|PMID:24075906
Biological Process	GO:0001501	skeletal system development	Trp63	IMP	MGI:MGI:1934269	Mouse	PMID:10227294
Biological Process	GO:0098773	skin epidermis development	Trp63	IMP	MGI:MGI:5882555	Mouse	PMID:25503409
Biological Process	GO:0098773	skin epidermis development	Trp63	IMP	MGI:MGI:5882553	Mouse	PMID:25503409
Biological Process	GO:0043589	skin morphogenesis	Trp63	IMP	MGI:MGI:3693324	Mouse	PMID:17041603
Biological Process	GO:0007283	spermatogenesis	Tp63	IEP		Rat	PMID:15292098\|RGD:2302247
Biological Process	GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:15371309
Biological Process	GO:0048863	stem cell differentiation	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:15371309
Biological Process	GO:0072089	stem cell proliferation	Trp63	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0072089	stem cell proliferation	Trp63	IMP	MGI:MGI:5882553	Mouse	PMID:25503409
Biological Process	GO:0048485	sympathetic nervous system development	Trp63	IMP	MGI:MGI:1934580	Mouse	PMID:16337913
Biological Process	GO:0006366	transcription by RNA polymerase II	Trp63	IMP	MGI:MGI:3795257	Mouse	PMID:18326838
Biological Process	GO:0006366	transcription by RNA polymerase II	Trp63	IMP	MGI:MGI:1861713	Mouse	PMID:15982302
Biological Process	GO:0006366	transcription by RNA polymerase II	Trp63	IDA		Mouse	PMID:23906066
Biological Process	GO:0006366	transcription by RNA polymerase II	Trp63	IMP		Mouse	PMID:18256694

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.