Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TP73
  • Mouse genes Trp73
  • Rat genes Tp73
  • Zfish genes tp73
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trp73

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Trp73	IDA		Mouse	PMID:16363065
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TP73	IDA		Human	PMID:16343436
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TP73	IGI	UniProtKB:P17208	Human	PMID:18421303
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TP73	IDA		Human	PMID:15678106
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TP73	IMP		Human	PMID:25417702
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Trp73	IDA		Mouse	PMID:16044147
Molecular Function	GO:0003700	DNA-binding transcription factor activity	tp73	IDA		Zfish	PMID:15541366
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	TP73	IDA		Human	PMID:24652652
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TP73	IPI	UniProtKB:P17208	Human	PMID:18421303
Molecular Function	GO:0042802	identical protein binding	TP73	IPI	UniProtKB:O15350	Human	PMID:10373484
Molecular Function	GO:0042802	identical protein binding	TP73	IPI	UniProtKB:O15350	Human	PMID:19815500
Molecular Function	GO:0042802	identical protein binding	TP73	IPI	UniProtKB:O15350	Human	PMID:22340593
Molecular Function	GO:0042802	identical protein binding	TP73	IPI	UniProtKB:O15350	Human	PMID:22474346
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	TP73	IPI	UniProtKB:Q00987	Human	PMID:25417702
Molecular Function	GO:0002039	p53 binding	TP73	IPI	UniProtKB:P04637	Human	PMID:25417702
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:O15151	Human	PMID:10469568
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:O15350	Human	PMID:10469568
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q9ESJ1	Human	PMID:11706030
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q13625	Human	PMID:14729977
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q96KQ4	Human	PMID:14729977
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q96J02	Human	PMID:15678106
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q96EB6	Human	PMID:16998810
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q96J02	Human	PMID:17592138
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q13625	Human	PMID:18275817
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:P46937	Human	PMID:18280240
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:P54278-1	Human	PMID:18768816
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q00987	Human	PMID:19218448
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q09472	Human	PMID:19218448
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:P0C2W1	Human	PMID:19581926
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q9H3D4	Human	PMID:19815500
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q7Z419	Human	PMID:20615966
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q9H3D4	Human	PMID:22252508
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:O14965	Human	PMID:22340593
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:P38646	Human	PMID:22340593
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:P46937	Human	PMID:25283809
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:Q13950	Human	PMID:25331851
Molecular Function	GO:0005515	protein binding	TP73	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Trp73	IPI	UniProtKB:P46938	Mouse	MGI:MGI:5508741|PMID:11278685
Molecular Function	GO:0019901	protein kinase binding	TP73	IPI	UniProtKB:P53350	Human	PMID:18174154
Molecular Function	GO:0019901	protein kinase binding	TP73	IPI	UniProtKB:Q9H4B4	Human	PMID:19490146
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TP73	IDA		Human	PMID:16343436
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	TP73	IPI	UniProtKB:P17208	Human	PMID:18421303
Molecular Function	GO:0043565	sequence-specific DNA binding	Tp73	IDA		Rat	PMID:15805112|RGD:1599582
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TP73	IDA		Human	PMID:16343436
Cellular Component	GO:0030054	cell junction	TP73	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000785	chromatin	Tp73	IDA		Rat	PMID:15805112|RGD:1599582
Cellular Component	GO:0005737	cytoplasm	Tp73	IDA		Rat	PMID:20519366|RGD:8693585
Cellular Component	GO:0005794	Golgi apparatus	TP73	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TP73	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TP73	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TP73	IDA		Human	PMID:19490146
Cellular Component	GO:0005634	nucleus	Trp73	IDA		Mouse	MGI:MGI:5688842|PMID:18421303
Cellular Component	GO:0005634	nucleus	Trp73	IDA		Mouse	PMID:15525772
Cellular Component	GO:0005634	nucleus	Trp73	IDA		Mouse	PMID:14555234
Cellular Component	GO:0005634	nucleus	Trp73	IDA		Mouse	PMID:15483136
Cellular Component	GO:0005634	nucleus	Tp73	IDA		Rat	PMID:15805112|RGD:1599582
Biological Process	GO:0033326	cerebrospinal fluid secretion	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:10716451
Biological Process	GO:0048546	digestive tract morphogenesis	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:10716451
Biological Process	GO:0006974	DNA damage response	TP73	IDA		Human	PMID:18174154
Biological Process	GO:0006974	DNA damage response	Trp73	IMP		Mouse	PMID:16044147
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	tp73	IMP	ZFIN:ZDB-MRPHLNO-050107-2	Zfish	PMID:18418056
Biological Process	GO:0030900	forebrain development	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:15525772
Biological Process	GO:0021766	hippocampus development	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:10716451
Biological Process	GO:0006954	inflammatory response	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:10716451
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TP73	IDA		Human	PMID:18174154
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TP73	IDA		Human	PMID:19490146
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Trp73	IGI	MGI:MGI:2442925	Mouse	PMID:15983387
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Trp73	IGI	MGI:MGI:98834	Mouse	PMID:15983387
Biological Process	GO:0001822	kidney development	Tp73	IEP		Rat	PMID:15805112|RGD:1599582
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	TP73	IMP		Human	PMID:18634800
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:12427836
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:10894779
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:15483136
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Trp73	IDA		Mouse	PMID:12427836
Biological Process	GO:0045665	negative regulation of neuron differentiation	Tp73	IMP		Rat	PMID:17353261|RGD:2291838
Biological Process	GO:0048666	neuron development	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:12427836
Biological Process	GO:0043065	positive regulation of apoptotic process	Tp73	IMP		Rat	PMID:15716325|RGD:2291842
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Trp73	IGI	PR:Q9QXE4-2	Mouse	PMID:16044147
Biological Process	GO:0045793	positive regulation of cell size	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:15483136
Biological Process	GO:0045793	positive regulation of cell size	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:12427836
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TP73	IDA		Human	PMID:15678106
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TP73	IDA		Human	PMID:16343436
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TP73	IMP		Human	PMID:25417702
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Trp73	IDA		Mouse	PMID:16044147
Biological Process	GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Trp73	IGI	MGI:MGI:98834	Mouse	PMID:15983387
Biological Process	GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Trp73	IGI	MGI:MGI:2442925	Mouse	PMID:15983387
Biological Process	GO:1901248	positive regulation of lung ciliated cell differentiation	TP73	IMP		Human	PMID:34077761
Biological Process	GO:0043410	positive regulation of MAPK cascade	Tp73	IMP		Rat	PMID:17353261|RGD:2291838
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Tp73	IMP		Rat	PMID:14960496|RGD:2291843
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP73	IDA		Human	PMID:16343436
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP73	IDA		Human	PMID:18174154
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP73	IDA		Human	PMID:18421303
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP73	IDA		Human	PMID:19490146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TP73	IDA		Human	PMID:24652652
Biological Process	GO:0009791	post-embryonic development	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:10716451
Biological Process	GO:0009791	post-embryonic development	Trp73	IMP	MGI:MGI:1859911	Mouse	PMID:15483136
Biological Process	GO:0051726	regulation of cell cycle	TP73	IDA		Human	PMID:18421303
Biological Process	GO:0006355	regulation of DNA-templated transcription	tp73	IDA		Zfish	PMID:15541366
Biological Process	GO:0010468	regulation of gene expression	TP73	IMP		Human	PMID:18634800
Biological Process	GO:0007346	regulation of mitotic cell cycle	TP73	IMP		Human	PMID:18634800
Biological Process	GO:0043523	regulation of neuron apoptotic process	Trp73	IGI	MGI:MGI:98834	Mouse	PMID:15483136
Biological Process	GO:0010243	response to organonitrogen compound	Tp73	IEP		Rat	PMID:14587038|RGD:2291845
Biological Process	GO:0009410	response to xenobiotic stimulus	Tp73	IEP		Rat	PMID:20519366|RGD:8693585

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern