Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPA1
  • Mouse genes Trpa1
  • Rat genes Trpa1
  • Zfish genes trpa1a,trpa1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	Trpa1	IDA		Mouse	PMID:12654248
Molecular Function	GO:0005262	calcium channel activity	Trpa1	IDA		Mouse	PMID:17588549
Molecular Function	GO:0005262	calcium channel activity	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:18398506
Molecular Function	GO:0015278	calcium-release channel activity	TRPA1	IDA		Human	PMID:20547126
Molecular Function	GO:0015278	calcium-release channel activity	TRPA1	IMP		Human	PMID:25855297
Molecular Function	GO:0015278	calcium-release channel activity	trpa1a	IDA		Zfish	PMID:27874100
Molecular Function	GO:0015278	calcium-release channel activity	trpa1b	IDA		Zfish	PMID:27874100
Molecular Function	GO:0015267	channel activity	Trpa1	IDA		Mouse	PMID:15483558
Molecular Function	GO:0015267	channel activity	trpa1b	IDA		Zfish	PMID:28928472
Molecular Function	GO:0042802	identical protein binding	TRPA1	IPI	UniProtKB:O75762	Human	PMID:25855297
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	trpa1a	IDA		Zfish	PMID:18829968
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	trpa1b	IDA		Zfish	PMID:18829968
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	trpa1a	IMP		Zfish	PMID:15483558
Molecular Function	GO:0005216	monoatomic ion channel activity	Trpa1	IMP		Mouse	PMID:15483558
Molecular Function	GO:0005216	monoatomic ion channel activity	Trpa1	IDA		Mouse	PMID:15843607
Molecular Function	GO:1990760	osmolarity-sensing monoatomic cation channel activity	Trpa1	IDA		Rat	PMID:18279313|RGD:10047048
Molecular Function	GO:0005515	protein binding	Trpa1	IPI	UniProtKB:Q9CQG9	Mouse	MGI:MGI:5621199|PMID:25640077
Molecular Function	GO:0005515	protein binding	Trpa1	IPI	RGD:628841	Rat	PMID:20231274|RGD:10043373
Molecular Function	GO:0097604	temperature-gated cation channel activity	TRPA1	IDA		Human	PMID:20547126
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Trpa1	IDA		Rat	PMID:14712238|RGD:1303969
Cellular Component	GO:0016324	apical plasma membrane	Trpa1	IDA		Rat	PMID:22207576|RGD:10043824
Cellular Component	GO:0030424	axon	Trpa1	IDA		Rat	PMID:18514429|RGD:10043379
Cellular Component	GO:0005886	plasma membrane	TRPA1	IMP		Human	PMID:20547126
Cellular Component	GO:0005886	plasma membrane	TRPA1	IMP		Human	PMID:25855297
Cellular Component	GO:0032421	stereocilium bundle	Trpa1	IDA		Mouse	PMID:15843607
Cellular Component	GO:0032421	stereocilium bundle	Trpa1	IDA		Mouse	PMID:15483558
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	Trpa1	IDA		Rat	PMID:14712238|RGD:1303969
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	Trpa1	IMP		Rat	PMID:31969645|RGD:127285811
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPA1	IMP		Human	PMID:20547126
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPA1	IMP		Human	PMID:25855297
Biological Process	GO:0006816	calcium ion transport	Trpa1	IDA		Mouse	PMID:17588549
Biological Process	GO:0006816	calcium ion transport	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:18398506
Biological Process	GO:0007166	cell surface receptor signaling pathway	Trpa1	IMP		Mouse	MGI:MGI:5621209|PMID:25605129
Biological Process	GO:0071313	cellular response to caffeine	Trpa1	IEP		Rat	PMID:22319196|RGD:10043374
Biological Process	GO:0071244	cellular response to carbon dioxide	Trpa1	IDA		Rat	PMID:20881114|RGD:10043825
Biological Process	GO:0070417	cellular response to cold	Trpa1	IMP		Rat	PMID:21068322|RGD:10043615
Biological Process	GO:0034605	cellular response to heat	Trpa1	IMP		Rat	PMID:22458587|RGD:10043621
Biological Process	GO:0070301	cellular response to hydrogen peroxide	TRPA1	IDA		Human	PMID:30990108
Biological Process	GO:0071310	cellular response to organic substance	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:30990108
Biological Process	GO:0071310	cellular response to organic substance	Trpa1	IMP		Mouse	PMID:30990108
Biological Process	GO:0071310	cellular response to organic substance	Trpa1	IDA		Mouse	PMID:30990108
Biological Process	GO:0007635	chemosensory behavior	trpa1b	IMP	ZFIN:ZDB-MRPHLNO-050106-4	Zfish	PMID:24155313
Biological Process	GO:0009593	detection of chemical stimulus	trpa1a	IDA		Zfish	PMID:18829968
Biological Process	GO:0050907	detection of chemical stimulus involved in sensory perception	trpa1b	IDA		Zfish	PMID:18829968
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpa1	IDA		Mouse	PMID:18272293
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:16564016
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpa1	IMP	MGI:MGI:3624810	Mouse	PMID:16630838
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpa1	IMP	MGI:MGI:3624810	Mouse	PMID:18297068
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:18398506
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	trpa1b	IGI	ZFIN:ZDB-GENO-090304-12	Zfish	PMID:18829968
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	Trpa1	IMP		Mouse	PMID:25101983
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	trpa1a	IMP		Zfish	PMID:15483558
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Trpa1	IMP	MGI:MGI:3624810	Mouse	PMID:16630838
Biological Process	GO:0006874	intracellular calcium ion homeostasis	TRPA1	IDA		Human	PMID:30990108
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:30990108
Biological Process	GO:0034220	monoatomic ion transmembrane transport	trpa1b	IDA		Zfish	PMID:18829968|ZFIN:ZDB-PUB-081008-3
Biological Process	GO:0034220	monoatomic ion transmembrane transport	trpa1a	IDA		Zfish	PMID:18829968
Biological Process	GO:0034220	monoatomic ion transmembrane transport	trpa1b	IDA		Zfish	PMID:18829968
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Trpa1	IMP		Rat	PMID:22701540|RGD:10043784
Biological Process	GO:1903793	positive regulation of monoatomic anion transport	Trpa1	IMP		Rat	PMID:22207576|RGD:10043824
Biological Process	GO:1904058	positive regulation of sensory perception of pain	Trpa1	IMP		Rat	PMID:24120766|RGD:10043614
Biological Process	GO:0051289	protein homotetramerization	TRPA1	IDA		Human	PMID:25855297
Biological Process	GO:1903522	regulation of blood circulation	Trpa1	IMP		Rat	PMID:22133672|RGD:10043378
Biological Process	GO:0098908	regulation of neuronal action potential	Trpa1	IMP		Rat	PMID:20205719|RGD:10043789
Biological Process	GO:0009409	response to cold	Trpa1	IMP	MGI:MGI:3624810	Mouse	PMID:16630838
Biological Process	GO:0009409	response to cold	Trpa1	IDA		Mouse	PMID:12654248
Biological Process	GO:0042542	response to hydrogen peroxide	Trpa1	IMP	MGI:MGI:3692770	Mouse	PMID:18398506
Biological Process	GO:0014070	response to organic cyclic compound	Trpa1	IMP		Mouse	MGI:MGI:5621209|PMID:25605129
Biological Process	GO:0010033	response to organic substance	TRPA1	IMP		Human	PMID:20547126
Biological Process	GO:0048265	response to pain	Trpa1	IDA		Mouse	PMID:18272293
Biological Process	GO:0048265	response to pain	Trpa1	IMP	MGI:MGI:3624810	Mouse	PMID:18297068
Biological Process	GO:0048265	response to pain	Trpa1	IMP	MGI:MGI:3624810	Mouse	PMID:16630838
Biological Process	GO:0009410	response to xenobiotic stimulus	Trpa1	IDA		Mouse	PMID:18272293
Biological Process	GO:0007606	sensory perception of chemical stimulus	trpa1b	IDA		Zfish	PMID:29561265
Biological Process	GO:0019233	sensory perception of pain	TRPA1	IMP		Human	PMID:20547126
Biological Process	GO:0019233	sensory perception of pain	Trpa1	IMP		Rat	PMID:31969645|RGD:127285811
Biological Process	GO:0050955	thermoception	Trpa1	IDA		Mouse	PMID:12654248
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	Trpa1	IMP		Rat	PMID:21367919|RGD:10043365

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern