Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPM2
  • Mouse genes Trpm2
  • Rat genes Trpm2
  • Zfish genes trpm2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0072570	ADP-D-ribose binding	trpm2	IDA		Zfish	PMID:31844070
Molecular Function	GO:0005262	calcium channel activity	trpm2	IDA		Zfish	PMID:35634784
Molecular Function	GO:0005509	calcium ion binding	TRPM2	IMP		Human	PMID:19171771
Molecular Function	GO:0005509	calcium ion binding	TRPM2	IDA		Human	PMID:30467180
Molecular Function	GO:0005509	calcium ion binding	trpm2	IDA		Zfish	PMID:30250252|ZFIN:ZDB-PUB-180927-5
Molecular Function	GO:0015278	calcium-release channel activity	TRPM2	IMP		Human	PMID:27068538
Molecular Function	GO:0099604	ligand-gated calcium channel activity	TRPM2	IDA		Human	PMID:19171771
Molecular Function	GO:0099604	ligand-gated calcium channel activity	TRPM2	IDA		Human	PMID:25620041
Molecular Function	GO:0099604	ligand-gated calcium channel activity	TRPM2	IDA		Human	PMID:27333281
Molecular Function	GO:0099604	ligand-gated calcium channel activity	TRPM2	IDA		Human	PMID:28775320
Molecular Function	GO:0099604	ligand-gated calcium channel activity	TRPM2	IDA		Human	PMID:29745897
Molecular Function	GO:0099604	ligand-gated calcium channel activity	TRPM2	IDA		Human	PMID:30467180
Molecular Function	GO:0099604	ligand-gated calcium channel activity	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Molecular Function	GO:0099604	ligand-gated calcium channel activity	trpm2	IDA		Zfish	PMID:30250252|ZFIN:ZDB-PUB-180927-5
Molecular Function	GO:0099094	ligand-gated monoatomic cation channel activity	trpm2	IDA		Zfish	PMID:33924946
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	Trpm2	IDA		Mouse	PMID:11804595
Molecular Function	GO:0072571	mono-ADP-D-ribose binding	TRPM2	IDA		Human	PMID:30467180
Molecular Function	GO:0072571	mono-ADP-D-ribose binding	trpm2	IDA		Zfish	PMID:30250252|ZFIN:ZDB-PUB-180927-5
Molecular Function	GO:0005261	monoatomic cation channel activity	TRPM2	IMP		Human	PMID:27068538
Molecular Function	GO:0005216	monoatomic ion channel activity	trpm2	IDA		Zfish	PMID:31844070
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Trpm2	IDA		Mouse	MGI:MGI:5298324|PMID:21753080
Cellular Component	GO:0005765	lysosomal membrane	Trpm2	IDA		Mouse	MGI:MGI:5298324|PMID:21753080
Cellular Component	GO:0005764	lysosome	TRPM2	IDA		Human	PMID:27068538
Cellular Component	GO:0043005	neuron projection	Trpm2	IDA		Rat	PMID:16651700|RGD:9999433
Cellular Component	GO:0043025	neuronal cell body	Trpm2	IDA		Rat	PMID:16651700|RGD:9999433
Cellular Component	GO:0005886	plasma membrane	TRPM2	IMP		Human	PMID:19171771
Cellular Component	GO:0005886	plasma membrane	TRPM2	IDA		Human	PMID:27333281
Cellular Component	GO:0005886	plasma membrane	TRPM2	IDA		Human	PMID:30467180
Cellular Component	GO:0005886	plasma membrane	Trpm2	IDA		Mouse	MGI:MGI:5298324|PMID:21753080
Cellular Component	GO:0005886	plasma membrane	Trpm2	IDA		Mouse	PMID:11804595
Cellular Component	GO:0005886	plasma membrane	Trpm2	IDA		Rat	PMID:16651700|RGD:9999433
Biological Process	GO:0098703	calcium ion import across plasma membrane	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Biological Process	GO:0098703	calcium ion import across plasma membrane	Trpm2	IMP		Rat	PMID:16651700|RGD:9999433
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	TRPM2	IMP		Human	PMID:19171771
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	TRPM2	IMP		Human	PMID:27068538
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPM2	IDA		Human	PMID:25620041
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPM2	IDA		Human	PMID:27333281
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPM2	IDA		Human	PMID:28775320
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPM2	IDA		Human	PMID:29745897
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPM2	IDA		Human	PMID:30467180
Biological Process	GO:0070588	calcium ion transmembrane transport	trpm2	IDA		Zfish	PMID:30250252|ZFIN:ZDB-PUB-180927-5
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Biological Process	GO:0071277	cellular response to calcium ion	TRPM2	IMP		Human	PMID:19171771
Biological Process	GO:0070301	cellular response to hydrogen peroxide	TRPM2	IDA		Human	PMID:27068538
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Trpm2	IDA		Rat	PMID:16651700|RGD:9999433
Biological Process	GO:0071415	cellular response to purine-containing compound	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Biological Process	GO:0071502	cellular response to temperature stimulus	Trpm2	IMP		Mouse	MGI:MGI:5795853|PMID:27562954
Biological Process	GO:0002407	dendritic cell chemotaxis	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Biological Process	GO:0097028	dendritic cell differentiation	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Biological Process	GO:0044849	estrous cycle	Trpm2	IEP		Rat	PMID:24577155|RGD:9999435
Biological Process	GO:0006828	manganese ion transport	Trpm2	IDA		Mouse	PMID:11804595
Biological Process	GO:0098655	monoatomic cation transmembrane transport	trpm2	IDA		Zfish	PMID:33924946|ZFIN:ZDB-PUB-210501-38
Biological Process	GO:1900409	positive regulation of cellular response to oxidative stress	Trpm2	IMP		Rat	PMID:16651700|RGD:9999433
Biological Process	GO:0032024	positive regulation of insulin secretion	Trpm2	IMP		Rat	PMID:16601673|RGD:9999436
Biological Process	GO:0051289	protein homotetramerization	TRPM2	IDA		Human	PMID:30467180
Biological Process	GO:0051289	protein homotetramerization	trpm2	IDA		Zfish	PMID:30250252|ZFIN:ZDB-PUB-180927-5
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	TRPM2	IMP		Human	PMID:27068538
Biological Process	GO:0051489	regulation of filopodium assembly	TRPM2	IMP		Human	PMID:27068538
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	TRPM2	IMP		Human	PMID:27068538
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Trpm2	IMP		Mouse	MGI:MGI:5298324|PMID:21753080
Biological Process	GO:0009408	response to heat	Trpm2	IMP		Mouse	MGI:MGI:5795853|PMID:27562954
Biological Process	GO:0033194	response to hydroperoxide	Trpm2	IDA		Mouse	PMID:11804595
Biological Process	GO:0014074	response to purine-containing compound	TRPM2	IMP		Human	PMID:19171771
Biological Process	GO:0001659	temperature homeostasis	Trpm2	IMP		Mouse	MGI:MGI:5795853|PMID:27562954
Biological Process	GO:0071577	zinc ion transmembrane transport	TRPM2	IMP		Human	PMID:27068538

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern