Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPV1
  • Mouse genes Trpv1
  • Rat genes Trpv1
  • Zfish genes trpv1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpv1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Trpv1	IDA		Rat	PMID:17582331|RGD:8553505
Molecular Function	GO:0005262	calcium channel activity	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:10764638
Molecular Function	GO:0005262	calcium channel activity	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:17767493
Molecular Function	GO:0015278	calcium-release channel activity	Trpv1	IMP		Rat	PMID:17582331|RGD:8553505
Molecular Function	GO:0005516	calmodulin binding	Trpv1	IDA		Rat	PMID:17582331|RGD:8553505
Molecular Function	GO:0017081	chloride channel regulator activity	Trpv1	IDA		Rat	PMID:17945192|RGD:2317104
Molecular Function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	Trpv1	IDA		Rat	PMID:17582331|RGD:8553505
Molecular Function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	TRPV1	IDA		Human	PMID:11226139
Molecular Function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	Trpv1	IDA		Rat	PMID:11226139|RGD:11535102
Molecular Function	GO:0042802	identical protein binding	Trpv1	IPI	UniProtKB:Q704Y3-1	Mouse	MGI:MGI:5917143|PMID:20351268
Molecular Function	GO:0042802	identical protein binding	Trpv1	IPI	UniProtKB:O35433-1	Rat	PMID:18490661|RGD:13432240
Molecular Function	GO:0042802	identical protein binding	Trpv1	IPI	UniProtKB:O35433	Rat	PMID:22575650|RGD:8554520
Molecular Function	GO:0042802	identical protein binding	Trpv1	IPI	UniProtKB:O35433	Rat	PMID:24305160|RGD:13432320
Molecular Function	GO:0042802	identical protein binding	Trpv1	IPI	UniProtKB:O35433	Rat	PMID:24305161|RGD:13432321
Molecular Function	GO:0042802	identical protein binding	Trpv1	IPI	UniProtKB:O35433	Rat	PMID:27281200|RGD:11344330
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	Trpv1	IDA		Rat	PMID:15764707|RGD:5688181
Molecular Function	GO:0005261	monoatomic cation channel activity	Trpv1	IDA		Rat	PMID:12598622|RGD:634416
Molecular Function	GO:0008324	monoatomic cation transmembrane transporter activity	Trpv1	IDA		Rat	PMID:10201375|RGD:70055
Molecular Function	GO:0035091	phosphatidylinositol binding	Trpv1	IDA		Rat	PMID:27281200|RGD:11344330
Molecular Function	GO:0051219	phosphoprotein binding	TRPV1	IPI	UniProtKB:P14314	Human	PMID:19801576
Molecular Function	GO:0005515	protein binding	TRPV1	IPI	UniProtKB:Q86VP3	Human	PMID:29656858
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	UniProtKB:Q9CQG9	Mouse	MGI:MGI:5621199|PMID:25640077
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	PR:Q8BFY0	Mouse	PMID:18455988
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	RGD:3965	Rat	PMID:16237318|RGD:2317111
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	RGD:620829	Rat	PMID:18701070|RGD:2313200
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	RGD:1303284	Rat	PMID:20231274|RGD:10043373
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	UniProtKB:P0CH43	Rat	PMID:20510930|RGD:13432350
Molecular Function	GO:0005515	protein binding	Trpv1	IPI	UniProtKB:P0CH43	Rat	PMID:27281200|RGD:11344330
Molecular Function	GO:0097603	temperature-gated ion channel activity	Trpv1	IMP		Mouse	MGI:MGI:5461590|PMID:22634729
Molecular Function	GO:0097603	temperature-gated ion channel activity	Trpv1	IDA		Mouse	PMID:18455988
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Trpv1	IDA		Rat	PMID:17582331|RGD:8553505
Cellular Component	GO:0005829	cytosol	Trpv1	IDA		Rat	PMID:17945192|RGD:2317104
Cellular Component	GO:0030425	dendrite	Trpv1	IDA		Rat	PMID:15857679|RGD:2317099
Cellular Component	GO:0009897	external side of plasma membrane	Trpv1	IDA		Rat	PMID:15764707|RGD:5688181
Cellular Component	GO:0016020	membrane	TRPV1	IDA		Human	PMID:10201375
Cellular Component	GO:0016020	membrane	Trpv1	IDA		Rat	PMID:10201375|RGD:70055
Cellular Component	GO:0016020	membrane	Trpv1	IDA		Rat	PMID:27281200|RGD:11344330
Cellular Component	GO:0005739	mitochondrion	Trpv1	IDA		Rat	PMID:27671317|RGD:13792689
Cellular Component	GO:0043005	neuron projection	Trpv1	IDA		Mouse	PMID:11466438
Cellular Component	GO:0043025	neuronal cell body	Trpv1	IDA		Rat	PMID:15857679|RGD:2317099
Cellular Component	GO:0005886	plasma membrane	Trpv1	IDA		Mouse	PMID:18455988
Cellular Component	GO:0005886	plasma membrane	Trpv1	IDA		Rat	PMID:11226139|RGD:11535102
Cellular Component	GO:0005886	plasma membrane	Trpv1	IDA		Rat	PMID:15857679|RGD:2317099
Cellular Component	GO:0005886	plasma membrane	Trpv1	IMP		Rat	PMID:17582331|RGD:8553505
Cellular Component	GO:0045211	postsynaptic membrane	Trpv1	IDA		Rat	PMID:15857679|RGD:2317099
Cellular Component	GO:0045202	synapse	Trpv1	IDA		Rat	PMID:15857679|RGD:2317099
Biological Process	GO:0048266	behavioral response to pain	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:18272658
Biological Process	GO:0048266	behavioral response to pain	Trpv1	IDA		Mouse	PMID:18455988
Biological Process	GO:0048266	behavioral response to pain	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:17767493
Biological Process	GO:0098703	calcium ion import across plasma membrane	TRPV1	IDA		Human	PMID:11226139
Biological Process	GO:0098703	calcium ion import across plasma membrane	Trpv1	IDA		Rat	PMID:11226139|RGD:11535102
Biological Process	GO:0070588	calcium ion transmembrane transport	Trpv1	IDA		Rat	PMID:11226139|RGD:11535102
Biological Process	GO:0070588	calcium ion transmembrane transport	Trpv1	IMP		Rat	PMID:17582331|RGD:8553505
Biological Process	GO:0006816	calcium ion transport	Trpv1	IDA		Mouse	PMID:17194758
Biological Process	GO:0006816	calcium ion transport	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:17767493
Biological Process	GO:0006816	calcium ion transport	Trpv1	IDA		Rat	PMID:15764707|RGD:5688181
Biological Process	GO:0042637	catagen	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:16645591
Biological Process	GO:0071468	cellular response to acidic pH	TRPV1	IDA		Human	PMID:11226139
Biological Process	GO:0071468	cellular response to acidic pH	Trpv1	IDA		Rat	PMID:11226139|RGD:11535102
Biological Process	GO:0071312	cellular response to alkaloid	Trpv1	IMP		Rat	PMID:17582331|RGD:8553505
Biological Process	GO:0071318	cellular response to ATP	Trpv1	IDA		Rat	PMID:17582331|RGD:8553505
Biological Process	GO:0071345	cellular response to cytokine stimulus	Trpv1	IDA		Rat	PMID:15764707|RGD:5688181
Biological Process	GO:0071363	cellular response to growth factor stimulus	Trpv1	IEP		Rat	PMID:17217411|RGD:2317106
Biological Process	GO:0034605	cellular response to heat	TRPV1	IDA		Human	PMID:11226139
Biological Process	GO:0034605	cellular response to heat	Trpv1	IDA		Rat	PMID:11226139|RGD:11535102
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Trpv1	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0071502	cellular response to temperature stimulus	Trpv1	IEP		Rat	PMID:20206612|RGD:2317098
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Trpv1	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpv1	IDA		Mouse	PMID:18272293
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:18297068
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Trpv1	IMP		Mouse	MGI:MGI:5461590|PMID:22634729
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Trpv1	IGI	UniProtKB:Q8BHY3	Mouse	MGI:MGI:5461590|PMID:22634729
Biological Process	GO:0050960	detection of temperature stimulus involved in thermoception	Trpv1	IDA		Mouse	PMID:18455988
Biological Process	GO:0002024	diet induced thermogenesis	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:12161756
Biological Process	GO:0001660	fever generation	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:15763167
Biological Process	GO:0030317	flagellated sperm motility	trpv1	IMP	ZFIN:ZDB-GENO-210708-22	Zfish	PMID:32251938
Biological Process	GO:0014047	glutamate secretion	Trpv1	IDA		Rat	PMID:18480286|RGD:2317101
Biological Process	GO:0006954	inflammatory response	Trpv1	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0006629	lipid metabolic process	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:12161756
Biological Process	GO:0001774	microglial cell activation	Trpv1	IMP		Rat	PMID:19385063|RGD:2316194
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Trpv1	IMP		Mouse	MGI:MGI:5461590|PMID:22634729
Biological Process	GO:0090212	negative regulation of establishment of blood-brain barrier	Trpv1	IMP		Rat	PMID:16056236|RGD:2317116
Biological Process	GO:0010459	negative regulation of heart rate	Trpv1	IMP		Rat	PMID:27335281|RGD:13792700
Biological Process	GO:0010917	negative regulation of mitochondrial membrane potential	Trpv1	IMP		Rat	PMID:27671317|RGD:13792689
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Trpv1	IMP		Rat	PMID:27335281|RGD:13792700
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Trpv1	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0002790	peptide secretion	Trpv1	IMP	MGI:MGI:3029186	Mouse	PMID:18172555
Biological Process	GO:0043065	positive regulation of apoptotic process	Trpv1	IMP		Rat	PMID:18996081|RGD:2317100
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpv1	IDA		Rat	PMID:18480286|RGD:2317101
Biological Process	GO:0060454	positive regulation of gastric acid secretion	Trpv1	IMP		Rat	PMID:15781048|RGD:2317117
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Trpv1	IMP		Rat	PMID:16081483|RGD:2317115
Biological Process	GO:0051289	protein homotetramerization	Trpv1	IDA		Rat	PMID:27281200|RGD:11344330
Biological Process	GO:1901594	response to capsazepine	TRPV1	IMP		Human	PMID:11226139
Biological Process	GO:1901594	response to capsazepine	Trpv1	IMP		Rat	PMID:11226139|RGD:11535102
Biological Process	GO:0009408	response to heat	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:10764638
Biological Process	GO:0009408	response to heat	Trpv1	IDA		Rat	PMID:10201375|RGD:70055
Biological Process	GO:0009408	response to heat	trpv1	IMP	ZFIN:ZDB-MRPHLNO-130412-4	Zfish	PMID:23516290
Biological Process	GO:0010243	response to organonitrogen compound	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:17767493
Biological Process	GO:0048265	response to pain	Trpv1	IDA		Mouse	PMID:18272293
Biological Process	GO:0048265	response to pain	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:18297068
Biological Process	GO:0043434	response to peptide hormone	Trpv1	IEP		Rat	PMID:16885226|RGD:2317110
Biological Process	GO:0009268	response to pH	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:10764638
Biological Process	GO:0009268	response to pH	Trpv1	IDA		Rat	PMID:10201375|RGD:70055
Biological Process	GO:0009268	response to pH	Trpv1	IEP		Rat	PMID:16191202|RGD:2317113
Biological Process	GO:0050954	sensory perception of mechanical stimulus	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:12161756
Biological Process	GO:0019233	sensory perception of pain	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:10764638
Biological Process	GO:0060083	smooth muscle contraction involved in micturition	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:12161756
Biological Process	GO:0001659	temperature homeostasis	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:10764638
Biological Process	GO:0050955	thermoception	TRPV1	IDA		Human	PMID:10201375
Biological Process	GO:0040040	thermosensory behavior	trpv1	IMP	ZFIN:ZDB-MRPHLNO-130412-4	Zfish	PMID:23516290
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	Trpv1	IMP	MGI:MGI:1934023	Mouse	PMID:12161756

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern