Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPV5
  • Mouse genes Trpv5
  • Rat genes Trpv5
  • Zfish genes trpv6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpv5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	TRPV5	IDA		Human	PMID:18768590
Molecular Function	GO:0005262	calcium channel activity	Trpv5	IDA		Mouse	MGI:MGI:3691711|PMID:15665527
Molecular Function	GO:0005262	calcium channel activity	Trpv5	IMP		Mouse	MGI:MGI:3687924|PMID:12574114
Molecular Function	GO:0005262	calcium channel activity	Trpv5	IMP		Rat	PMID:10875938|RGD:632623
Molecular Function	GO:0005262	calcium channel activity	Trpv5	IDA		Rat	PMID:19463684|RGD:7205490
Molecular Function	GO:0005262	calcium channel activity	trpv6	IDA		Zfish	PMID:31526479
Molecular Function	GO:0005262	calcium channel activity	trpv6	IDA		Zfish	PMID:21670068
Molecular Function	GO:0005262	calcium channel activity	trpv6	IMP	ZFIN:ZDB-GENO-111011-4	Zfish	PMID:21670068
Molecular Function	GO:0005515	protein binding	TRPV5	IPI	UniProtKB:P05937	Human	PMID:16763551
Molecular Function	GO:0005515	protein binding	Trpv5	IPI	UniProtKB:Q9JHL1	Mouse	MGI:MGI:3693405|PMID:15355307
Molecular Function	GO:0005515	protein binding	Trpv5	IPI	UniProtKB:Q80UE6	Mouse	MGI:MGI:5550300|PMID:24434184
Molecular Function	GO:0005515	protein binding	Trpv5	IPI	UniProtKB:Q91WD2	Mouse	MGI:MGI:3687924|PMID:12574114
Molecular Function	GO:0005515	protein binding	Trpv5	IPI	UniProtKB:Q9WVC6	Mouse	MGI:MGI:3691711|PMID:15665527
Cellular Component	GO:0016324	apical plasma membrane	Trpv5	IDA		Mouse	PMID:12205031
Cellular Component	GO:0016324	apical plasma membrane	Trpv5	IDA		Rat	PMID:11423563|RGD:7205501
Cellular Component	GO:0034704	calcium channel complex	Trpv5	IDA		Mouse	MGI:MGI:3687924|PMID:12574114
Cellular Component	GO:0005886	plasma membrane	TRPV5	IDA		Human	PMID:15489237
Cellular Component	GO:0005886	plasma membrane	TRPV5	IDA		Human	PMID:18768590
Cellular Component	GO:0005886	plasma membrane	Trpv5	IMP		Rat	PMID:10875938|RGD:632623
Biological Process	GO:0055074	calcium ion homeostasis	Trpv5	IMP		Mouse	MGI:MGI:2682494|PMID:14679186
Biological Process	GO:0055074	calcium ion homeostasis	trpv6	IMP	ZFIN:ZDB-GENO-111011-4	Zfish	PMID:21670068
Biological Process	GO:0070509	calcium ion import	trpv6	IMP	ZFIN:ZDB-MRPHLNO-090924-2	Zfish	PMID:19073903
Biological Process	GO:0098703	calcium ion import across plasma membrane	TRPV5	IDA		Human	PMID:18768590
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPV5	IDA		Human	PMID:18768590
Biological Process	GO:0070588	calcium ion transmembrane transport	Trpv5	IMP		Mouse	MGI:MGI:3687924|PMID:12574114
Biological Process	GO:0070588	calcium ion transmembrane transport	Trpv5	IMP		Rat	PMID:10875938|RGD:632623
Biological Process	GO:0006816	calcium ion transport	Trpv5	IDA		Mouse	MGI:MGI:3691711|PMID:15665527
Biological Process	GO:0060402	calcium ion transport into cytosol	Trpv5	IDA		Rat	PMID:19463684|RGD:7205490
Biological Process	GO:0042539	hypotonic salinity response	trpv6	IDA		Zfish	PMID:17299134
Biological Process	GO:0070317	negative regulation of G0 to G1 transition	trpv6	IMP	ZFIN:ZDB-GENO-200910-3	Zfish	PMID:31526479
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	trpv6	IGI	ZFIN:ZDB-GENE-040426-1521,ZFIN:ZDB-MRPHLNO-090924-2	Zfish	PMID:19073903
Biological Process	GO:0035809	regulation of urine volume	Trpv5	IMP		Mouse	MGI:MGI:2682494|PMID:14679186
Biological Process	GO:0051592	response to calcium ion	trpv6	IDA		Zfish	PMID:15947067

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern