Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRSS1,PRSS2,PRSS3,PRSS3P2
  • Mouse genes Try4
  • Rat genes Try5
  • Zfish genes prss1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Try4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	PRSS2	IDA		Human	PMID:12709065
Molecular Function	GO:0005509	calcium ion binding	PRSS3	IDA		Human	PMID:11827488
Molecular Function	GO:0005509	calcium ion binding	PRSS3	IDA		Human	PMID:6698368
Molecular Function	GO:0005515	protein binding	PRSS2	IPI	UniProtKB:P01009	Human	PMID:16192646
Molecular Function	GO:0005515	protein binding	PRSS3	IPI	UniProtKB:P00995	Human	PMID:14507909
Molecular Function	GO:0005515	protein binding	PRSS3	IPI	UniProtKB:P01023	Human	PMID:6698368
Molecular Function	GO:0004252	serine-type endopeptidase activity	PRSS2	IDA		Human	PMID:12709065
Molecular Function	GO:0004252	serine-type endopeptidase activity	PRSS2	IDA		Human	PMID:12731883
Molecular Function	GO:0004252	serine-type endopeptidase activity	PRSS3	IDA		Human	PMID:11827488
Molecular Function	GO:0004252	serine-type endopeptidase activity	PRSS3	IDA		Human	PMID:14507909
Molecular Function	GO:0004252	serine-type endopeptidase activity	PRSS3	IDA		Human	PMID:25301953
Molecular Function	GO:0004252	serine-type endopeptidase activity	PRSS3	IDA		Human	PMID:6698368
Molecular Function	GO:0004252	serine-type endopeptidase activity	Try4	IDA		Mouse	PMID:23814066
Cellular Component	GO:0072562	blood microparticle	PRSS1	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PRSS1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Try4	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005576	extracellular region	PRSS2	IDA		Human	PMID:12731883
Cellular Component	GO:0005615	extracellular space	PRSS2	IMP		Human	PMID:16192646
Cellular Component	GO:0005615	extracellular space	PRSS3	IDA		Human	PMID:6698368
Biological Process	GO:0030574	collagen catabolic process	PRSS2	IDA		Human	PMID:12731883
Biological Process	GO:0030574	collagen catabolic process	PRSS2	IMP		Human	PMID:16192646
Biological Process	GO:0043542	endothelial cell migration	PRSS3	IMP		Human	PMID:15313892
Biological Process	GO:0043542	endothelial cell migration	PRSS3P2	IMP		Human	PMID:15313892
Biological Process	GO:0006508	proteolysis	PRSS2	IDA		Human	PMID:12731883
Biological Process	GO:0006508	proteolysis	PRSS3	IDA		Human	PMID:11827488
Biological Process	GO:0006508	proteolysis	PRSS3	IDA		Human	PMID:6698368
Biological Process	GO:0031638	zymogen activation	PRSS3	IDA		Human	PMID:6698368

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern