Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tsc1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TSC1
- Mouse genes Tsc1
- Rat genes Tsc1
- Zfish genes tsc1a,tsc1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tsc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042030	ATPase inhibitor activity	TSC1	IDA		Human	PMID:29127155
Molecular Function	GO:0042030	ATPase inhibitor activity	Tsc1	IMP		Mouse	MGI:MGI:6148662\|PMID:29127155
Molecular Function	GO:0030544	Hsp70 protein binding	TSC1	IDA		Human	PMID:29127155
Molecular Function	GO:0051879	Hsp90 protein binding	TSC1	IPI	UniProtKB:P07900	Human	PMID:29127155
Molecular Function	GO:0051879	Hsp90 protein binding	TSC1	IPI	UniProtKB:P07900,UniProtKB:P49815	Human	PMID:29127155
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:10585443
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P15311	Human	PMID:10806479
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P07196	Human	PMID:12226091
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P02794	Human	PMID:17355907
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q00994	Human	PMID:17355907
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q9P0N9	Human	PMID:17658474
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:O14920	Human	PMID:17693255
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:17693255
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q969U6	Human	PMID:18381890
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P58004	Human	PMID:18692468
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q16539	Human	PMID:20368287
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:20412061
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:21134130
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P02794	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q674X7	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q92844	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:25263562
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q9P0N9	Human	PMID:26893383
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:O94763	Human	PMID:28561026
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:Q9H6T3	Human	PMID:28561026
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:9580671
Molecular Function	GO:0005515	protein binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:9809973
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	UniProtKB:D3YZU1	Mouse	MGI:MGI:5014114\|PMID:21653829
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	UniProtKB:Q61037	Mouse	MGI:MGI:5508563\|PMID:20412061
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	UniProtKB:P58043	Mouse	MGI:MGI:3808916\|PMID:18692468
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	UniProtKB:P15311\|UniProtKB:P26038\|UniProtKB:P35241	Mouse	MGI:MGI:3722502\|PMID:10806479
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	UniProtKB:Q61037	Mouse	MGI:MGI:6092779\|PMID:28671696
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	RGD:3148	Rat	PMID:17355907\|RGD:11570512
Molecular Function	GO:0005515	protein binding	Tsc1	IPI	RGD:621526	Rat	PMID:21925170\|RGD:9999170
Molecular Function	GO:0051087	protein-folding chaperone binding	TSC1	IPI	UniProtKB:P49815	Human	PMID:10585443
Cellular Component	GO:0005884	actin filament	TSC1	IDA		Human	PMID:10806479
Cellular Component	GO:0005938	cell cortex	TSC1	IDA		Human	PMID:10806479
Cellular Component	GO:0042995	cell projection	Tsc1	IDA		Rat	PMID:17376623\|RGD:11568689
Cellular Component	GO:0005737	cytoplasm	TSC1	IDA		Human	PMID:9580671
Cellular Component	GO:0005737	cytoplasm	Tsc1	IDA		Mouse	PMID:16286931
Cellular Component	GO:0005737	cytoplasm	Tsc1	IDA		Mouse	PMID:11741832
Cellular Component	GO:0005856	cytoskeleton	Tsc1	IDA		Rat	PMID:12147258\|RGD:1601407
Cellular Component	GO:0005829	cytosol	TSC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	TSC1	IDA		Human	PMID:10585443
Cellular Component	GO:0005829	cytosol	Tsc1	IDA		Rat	PMID:12147258\|RGD:1601407
Cellular Component	GO:0005794	Golgi apparatus	tsc1a	IDA		Zfish	PMID:19008302
Cellular Component	GO:0030426	growth cone	Tsc1	IDA		Rat	PMID:12226091\|RGD:633519
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Tsc1	IDA		Rat	PMID:12147258\|RGD:1601407
Cellular Component	GO:0030027	lamellipodium	TSC1	IDA		Human	PMID:10806479
Cellular Component	GO:0005811	lipid droplet	TSC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	TSC1	IDA		Human	PMID:16636147
Cellular Component	GO:0005634	nucleus	Tsc1	IDA		Rat	PMID:23435171\|RGD:10448950
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Tsc1	IDA		Rat	PMID:23435171\|RGD:10448950
Cellular Component	GO:0014069	postsynaptic density	Tsc1	EXP		Mouse	PMID:25211037
Cellular Component	GO:0014069	postsynaptic density	Tsc1	IDA		Mouse	PMID:25211037
Cellular Component	GO:0101031	protein folding chaperone complex	TSC1	IDA		Human	PMID:29127155
Cellular Component	GO:0032991	protein-containing complex	TSC1	IDA		Human	PMID:10585443
Cellular Component	GO:0033596	TSC1-TSC2 complex	TSC1	EXP		Human	PMID:26893383
Cellular Component	GO:0033596	TSC1-TSC2 complex	TSC1	IPI		Human	PMID:22795129
Cellular Component	GO:0033596	TSC1-TSC2 complex	TSC1	IDA		Human	PMID:9580671
Biological Process	GO:0090630	activation of GTPase activity	TSC1	IDA		Human	PMID:10806479
Biological Process	GO:0002250	adaptive immune response	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:25271321
Biological Process	GO:0008344	adult locomotory behavior	Tsc1	IMP		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0008306	associative learning	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:26158416
Biological Process	GO:0055007	cardiac muscle cell differentiation	Tsc1	IMP	MGI:MGI:2183146	Mouse	PMID:11438694
Biological Process	GO:0008283	cell population proliferation	Tsc1	IMP	MGI:MGI:2183146	Mouse	PMID:11438694
Biological Process	GO:0030030	cell projection organization	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:16286931
Biological Process	GO:0007160	cell-matrix adhesion	TSC1	IMP		Human	PMID:10806479
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Tsc1	IMP		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0021987	cerebral cortex development	Tsc1	IMP	MGI:MGI:2176055,MGI:MGI:2656240	Mouse	PMID:17522300
Biological Process	GO:0060271	cilium assembly	tsc1a	IMP	ZFIN:ZDB-MRPHLNO-090428-5	Zfish	PMID:19008302
Biological Process	GO:0007368	determination of left/right symmetry	tsc1a	IMP	ZFIN:ZDB-MRPHLNO-090428-5	Zfish	PMID:19008302
Biological Process	GO:0009790	embryo development	Tsc1	IMP	MGI:MGI:3584174	Mouse	PMID:15888477
Biological Process	GO:0046323	glucose import	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:18511518
Biological Process	GO:0021766	hippocampus development	Tsc1	IMP	MGI:MGI:2176055,MGI:MGI:2656240	Mouse	PMID:17522300
Biological Process	GO:0001822	kidney development	Tsc1	IMP	MGI:MGI:3584174	Mouse	PMID:15888477
Biological Process	GO:0043379	memory T cell differentiation	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:25271321
Biological Process	GO:0042552	myelination	Tsc1	IMP	MGI:MGI:2176055,MGI:MGI:2656240	Mouse	PMID:17522300
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	TSC1	IDA		Human	PMID:29127155
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	Tsc1	IMP		Mouse	MGI:MGI:6148662\|PMID:29127155
Biological Process	GO:0008285	negative regulation of cell population proliferation	TSC1	IMP		Human	PMID:10915759
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc1	IMP	MGI:MGI:2183146	Mouse	PMID:11438694
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc1	IMP		Rat	PMID:17376623\|RGD:11568689
Biological Process	GO:0045792	negative regulation of cell size	Tsc1	IGI	MGI:MGI:1928394	Mouse	PMID:16286931
Biological Process	GO:0045792	negative regulation of cell size	Tsc1	IMP	MGI:MGI:2656240,MGI:MGI:2656248	Mouse	PMID:15664737
Biological Process	GO:0045792	negative regulation of cell size	Tsc1	IMP	MGI:MGI:2176055,MGI:MGI:2656240	Mouse	PMID:17522300
Biological Process	GO:0045792	negative regulation of cell size	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:16286931
Biological Process	GO:0045792	negative regulation of cell size	Tsc1	IGI	MGI:MGI:1928394	Mouse	PMID:15185396
Biological Process	GO:1900408	negative regulation of cellular response to oxidative stress	Tsc1	IMP		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0034260	negative regulation of GTPase activity	Tsc1	IMP		Rat	PMID:15611338\|RGD:1601406
Biological Process	GO:0016242	negative regulation of macroautophagy	Tsc1	IMP		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0010977	negative regulation of neuron projection development	Tsc1	IMP		Rat	PMID:17376623\|RGD:11568689
Biological Process	GO:0032007	negative regulation of TOR signaling	TSC1	IMP		Human	PMID:17308101
Biological Process	GO:0032007	negative regulation of TOR signaling	TSC1	IDA		Human	PMID:22795129
Biological Process	GO:0032007	negative regulation of TOR signaling	TSC1	IMP		Human	PMID:28215400
Biological Process	GO:0032007	negative regulation of TOR signaling	Tsc1	IMP		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0017148	negative regulation of translation	TSC1	IMP		Human	PMID:17308101
Biological Process	GO:0007399	nervous system development	Tsc1	IMP	MGI:MGI:2176055,MGI:MGI:2656240	Mouse	PMID:17522300
Biological Process	GO:0001843	neural tube closure	Tsc1	IMP	MGI:MGI:2183146	Mouse	PMID:11438694
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	TSC1	IDA		Human	PMID:10806479
Biological Process	GO:0016239	positive regulation of macroautophagy	Tsc1	IDA		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Tsc1	IMP		Rat	PMID:15611338\|RGD:1601406
Biological Process	GO:0006813	potassium ion transport	Tsc1	IMP	MGI:MGI:2656240,MGI:MGI:2656248	Mouse	PMID:16393152
Biological Process	GO:0006813	potassium ion transport	Tsc1	IGI	MGI:MGI:104772	Mouse	PMID:16393152
Biological Process	GO:0006813	potassium ion transport	Tsc1	IGI	MGI:MGI:104565	Mouse	PMID:16393152
Biological Process	GO:0048793	pronephros development	tsc1a	IGI	ZFIN:ZDB-MRPHLNO-090428-5,ZFIN:ZDB-MRPHLNO-090428-7	Zfish	PMID:19008302
Biological Process	GO:0048793	pronephros development	tsc1a	IMP	ZFIN:ZDB-MRPHLNO-090428-5	Zfish	PMID:19008302
Biological Process	GO:0048793	pronephros development	tsc1a	IGI	ZFIN:ZDB-MRPHLNO-090428-5,ZFIN:ZDB-MRPHLNO-090428-8	Zfish	PMID:19008302
Biological Process	GO:0050821	protein stabilization	TSC1	IDA		Human	PMID:11175345
Biological Process	GO:0050821	protein stabilization	TSC1	IMP		Human	PMID:29127155
Biological Process	GO:0050821	protein stabilization	Tsc1	IMP		Mouse	MGI:MGI:6148662\|PMID:29127155
Biological Process	GO:0001952	regulation of cell-matrix adhesion	TSC1	IMP		Human	PMID:10806479
Biological Process	GO:0051893	regulation of focal adhesion assembly	Tsc1	IMP		Rat	PMID:15611338\|RGD:1601406
Biological Process	GO:1901214	regulation of neuron death	Tsc1	IMP		Rat	PMID:23435171\|RGD:10448950
Biological Process	GO:0043666	regulation of phosphoprotein phosphatase activity	TSC1	IMP		Human	PMID:17308101
Biological Process	GO:0045859	regulation of protein kinase activity	Tsc1	IGI	MGI:MGI:1928394	Mouse	PMID:15185396
Biological Process	GO:0051492	regulation of stress fiber assembly	TSC1	IDA		Human	PMID:10806479
Biological Process	GO:0032006	regulation of TOR signaling	tsc1a	IMP	ZFIN:ZDB-MRPHLNO-090428-5	Zfish	PMID:19008302
Biological Process	GO:0006417	regulation of translation	TSC1	IDA		Human	PMID:17308101
Biological Process	GO:0032868	response to insulin	TSC1	IDA		Human	PMID:16996505
Biological Process	GO:0031667	response to nutrient levels	Tsc1	IEP		Rat	PMID:31787541\|RGD:25823196
Biological Process	GO:1901652	response to peptide	Tsc1	IEP		Rat	PMID:31787541\|RGD:25823196
Biological Process	GO:0006407	rRNA export from nucleus	TSC1	IMP		Human	PMID:17308101
Biological Process	GO:0050808	synapse organization	Tsc1	IMP	MGI:MGI:2656240	Mouse	PMID:16286931

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.