Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TSHR
  • Mouse genes Tshr
  • Rat genes Tshr
  • Zfish genes tshr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tshr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TSHR	IPI	UniProtKB:Q14160	Human	PMID:15775968
Molecular Function	GO:0005515	protein binding	TSHR	IPI	UniProtKB:P21579	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	TSHR	IPI	UniProtKB:P30542	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	TSHR	IPI	UniProtKB:Q9NPA3	Human	PMID:28298427
Molecular Function	GO:0044877	protein-containing complex binding	TSHR	IDA		Human	PMID:12045258
Molecular Function	GO:0038023	signaling receptor activity	TSHR	IMP		Human	PMID:12045258
Molecular Function	GO:0004996	thyroid-stimulating hormone receptor activity	TSHR	IMP		Human	PMID:11847099
Molecular Function	GO:0004996	thyroid-stimulating hormone receptor activity	Tshr	IDA		Mouse	PMID:11440271
Molecular Function	GO:0004996	thyroid-stimulating hormone receptor activity	Tshr	IDA		Mouse	PMID:7789342
Molecular Function	GO:0004996	thyroid-stimulating hormone receptor activity	Tshr	IMP		Rat	PMID:1696008|RGD:729945
Molecular Function	GO:0004996	thyroid-stimulating hormone receptor activity	tshr	IDA		Zfish	PMID:21737742
Cellular Component	GO:0016323	basolateral plasma membrane	TSHR	IDA		Human	PMID:11847099
Cellular Component	GO:0045121	membrane raft	Tshr	IDA		Rat	PMID:17412816|RGD:8548670
Cellular Component	GO:0005886	plasma membrane	TSHR	IDA		Human	PMID:11847099
Cellular Component	GO:0005886	plasma membrane	Tshr	IDA		Mouse	PMID:7789342
Cellular Component	GO:0043235	receptor complex	TSHR	IDA		Human	PMID:23382219
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	TSHR	IMP		Human	PMID:12045258
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Tshr	IDA		Mouse	PMID:11440271
Biological Process	GO:0008344	adult locomotory behavior	Tshr	IMP	MGI:MGI:1856914	Mouse	PMID:11530227
Biological Process	GO:0030183	B cell differentiation	Tshr	IMP	MGI:MGI:1856914	Mouse	PMID:9300691
Biological Process	GO:0007166	cell surface receptor signaling pathway	TSHR	IMP		Human	PMID:12045258
Biological Process	GO:1904588	cellular response to glycoprotein	TSHR	IMP		Human	PMID:12045258
Biological Process	GO:1905229	cellular response to thyrotropin-releasing hormone	TSHR	IMP		Human	PMID:11847099
Biological Process	GO:0090103	cochlea morphogenesis	Tshr	IMP		Mouse	PMID:10575115
Biological Process	GO:0071542	dopaminergic neuron differentiation	Tshr	IMP	MGI:MGI:1856914	Mouse	PMID:10575115
Biological Process	GO:0060119	inner ear receptor cell development	Tshr	IMP	MGI:MGI:1856914	Mouse	PMID:10575115
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Tshr	IMP		Mouse	PMID:10575115
Biological Process	GO:0008284	positive regulation of cell population proliferation	Tshr	IDA		Rat	PMID:18719020|RGD:8548667
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Tshr	IMP		Mouse	MGI:MGI:3810900|PMID:18559984
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Tshr	IMP	MGI:MGI:1859614	Mouse	PMID:11530227
Biological Process	GO:0040012	regulation of locomotion	Tshr	IMP	MGI:MGI:1856914	Mouse	PMID:11530227
Biological Process	GO:0001501	skeletal system development	tshr	IMP	ZFIN:ZDB-GENO-141222-1	Zfish	PMID:28884682
Biological Process	GO:0038194	thyroid-stimulating hormone signaling pathway	TSHR	IMP		Human	PMID:11847099
Biological Process	GO:0038194	thyroid-stimulating hormone signaling pathway	Tshr	IDA		Mouse	MGI:MGI:74157|PMID:7789342

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern