Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TTC21B
  • Mouse genes Ttc21b
  • Rat genes Ttc21b
  • Zfish genes ttc21b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ttc21b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Ttc21b	IDA		Mouse	PMID:22079090
Molecular Function	GO:0005515	protein binding	TTC21B	IPI	UniProtKB:Q9HBG6-3	Human	PMID:29220510
Cellular Component	GO:0030991	intraciliary transport particle A	TTC21B	IPI		Human	PMID:27173435
Cellular Component	GO:0030991	intraciliary transport particle A	TTC21B	IDA		Human	PMID:20889716
Cellular Component	GO:0030991	intraciliary transport particle A	TTC21B	IDA		Human	PMID:27932497
Cellular Component	GO:0030991	intraciliary transport particle A	Ttc21b	IDA		Mouse	PMID:20889716
Biological Process	GO:0060020	Bergmann glial cell differentiation	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2179048,MGI:MGI:5587034	Mouse	PMID:29615573
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2179048,MGI:MGI:5587034	Mouse	PMID:29615573
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	Ttc21b	IMP	MGI:MGI:2137515,MGI:MGI:2152544,MGI:MGI:5587034	Mouse	PMID:29615573
Biological Process	GO:0021549	cerebellum development	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2179048,MGI:MGI:5587034	Mouse	PMID:29615573
Biological Process	GO:0030900	forebrain development	Ttc21b	IMP	MGI:MGI:2686837,MGI:MGI:5587034	Mouse	PMID:28291836
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	Ttc21b	IMP	MGI:MGI:2152544	Mouse	PMID:19732765
Biological Process	GO:0007369	gastrulation	ttc21b	IMP	ZFIN:ZDB-MRPHLNO-141007-2	Zfish	PMID:21258341
Biological Process	GO:0007369	gastrulation	ttc21b	IMP	ZFIN:ZDB-MRPHLNO-141007-1	Zfish	PMID:21258341
Biological Process	GO:0035721	intraciliary retrograde transport	Ttc21b	IMP		Mouse	PMID:18327258
Biological Process	GO:0035721	intraciliary retrograde transport	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2669525,MGI:MGI:5587034	Mouse	PMID:27482817
Biological Process	GO:0035721	intraciliary retrograde transport	Ttc21b	IMP	MGI:MGI:2152544	Mouse	PMID:19732765
Biological Process	GO:1903999	negative regulation of eating behavior	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2669525,MGI:MGI:5587034	Mouse	PMID:27482817
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2669525,MGI:MGI:5587034	Mouse	PMID:27482817
Biological Process	GO:0010628	positive regulation of gene expression	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2669525,MGI:MGI:5587034	Mouse	PMID:27482817
Biological Process	GO:0061512	protein localization to cilium	TTC21B	IMP		Human	PMID:20889716
Biological Process	GO:0097499	protein localization to non-motile cilium	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2669525,MGI:MGI:5587034	Mouse	PMID:27482817
Biological Process	GO:1905799	regulation of intraciliary retrograde transport	TTC21B	IMP		Human	PMID:27932497
Biological Process	GO:0008589	regulation of smoothened signaling pathway	Ttc21b	IMP	MGI:MGI:2152544	Mouse	PMID:19732765
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	TTC21B	IMP		Human	PMID:22302990
Biological Process	GO:0007224	smoothened signaling pathway	Ttc21b	IMP	MGI:MGI:2152544,MGI:MGI:2179048,MGI:MGI:5587034	Mouse	PMID:29615573
Biological Process	GO:0007224	smoothened signaling pathway	Ttc21b	IMP	MGI:MGI:2152544	Mouse	PMID:18327258
Biological Process	GO:0021591	ventricular system development	Ttc21b	IMP	MGI:MGI:2152544	Mouse	PMID:19732765

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern