Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TTC8
  • Mouse genes Ttc8
  • Rat genes Ttc8
  • Zfish genes ttc8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ttc8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q15154	Human	PMID:14520415
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q9BUN5	Human	PMID:16327777
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q3SYG4	Human	PMID:17574030
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q9NRI5	Human	PMID:18762586
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q9UPN4	Human	PMID:24550735
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:P98161	Human	PMID:24939912
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q8N3I7	Human	PMID:24939912
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q8NFJ9	Human	PMID:24939912
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q96RK4	Human	PMID:24939912
Molecular Function	GO:0005515	protein binding	TTC8	IPI	UniProtKB:Q15051	Human	PMID:25552655
Molecular Function	GO:0005515	protein binding	Ttc8	IPI	PR:Q8BMD2	Mouse	PMID:27979967
Molecular Function	GO:0005515	protein binding	Ttc8	IPI	PR:Q91ZD4	Mouse	PMID:25605782
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	TTC8	IPI	UniProtKB:Q99496	Human	PMID:22302990
Cellular Component	GO:0034464	BBSome	TTC8	IPI		Human	PMID:19081074
Cellular Component	GO:0034464	BBSome	TTC8	IDA		Human	PMID:17574030
Cellular Component	GO:0034464	BBSome	TTC8	IDA		Human	PMID:20080638
Cellular Component	GO:0034464	BBSome	TTC8	IDA		Human	PMID:24550735
Cellular Component	GO:0034464	BBSome	Ttc8	IDA		Mouse	MGI:MGI:5560383|PMID:24550735
Cellular Component	GO:0034464	BBSome	Ttc8	IDA		Mouse	PMID:22072986
Cellular Component	GO:0034464	BBSome	Ttc8	IDA		Mouse	PMID:22500027
Cellular Component	GO:0034464	BBSome	Ttc8	IDA		Mouse	PMID:20080638
Cellular Component	GO:0005813	centrosome	TTC8	IDA		Human	PMID:14520415
Cellular Component	GO:0036064	ciliary basal body	TTC8	IDA		Human	PMID:14520415
Cellular Component	GO:0060170	ciliary membrane	TTC8	IDA		Human	PMID:19081074
Cellular Component	GO:0005929	cilium	TTC8	IDA		Human	PMID:14520415
Cellular Component	GO:0005929	cilium	Ttc8	IDA		Mouse	MGI:MGI:5787768|PMID:25243405
Cellular Component	GO:0016020	membrane	Ttc8	IDA		Mouse	PMID:22139371
Cellular Component	GO:0032391	photoreceptor connecting cilium	Ttc8	IDA		Mouse	MGI:MGI:2677624|PMID:14520415
Biological Process	GO:0007015	actin filament organization	ttc8	IGI	ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0007015	actin filament organization	ttc8	IGI	ZFIN:ZDB-GENO-070305-2,ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0007411	axon guidance	Ttc8	IGI	MGI:MGI:1931271	Mouse	PMID:21646512
Biological Process	GO:0007411	axon guidance	Ttc8	IGI	MGI:MGI:109148	Mouse	PMID:21646512
Biological Process	GO:0060219	camera-type eye photoreceptor cell differentiation	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512
Biological Process	GO:0060271	cilium assembly	Ttc8	IMP		Mouse	MGI:MGI:5526920|PMID:22479622
Biological Process	GO:0060271	cilium assembly	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512
Biological Process	GO:0060271	cilium assembly	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:25605782
Biological Process	GO:0060271	cilium assembly	ttc8	IGI	ZFIN:ZDB-GENO-070305-2,ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0060271	cilium assembly	ttc8	IMP	ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0060026	convergent extension	ttc8	IMP	ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0060026	convergent extension	ttc8	IGI	ZFIN:ZDB-MRPHLNO-060301-2,ZFIN:ZDB-MRPHLNO-070605-8	Zfish	PMID:20207966
Biological Process	GO:0060026	convergent extension	ttc8	IGI	ZFIN:ZDB-GENO-070305-2,ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0048560	establishment of anatomical structure orientation	TTC8	IMP		Human	PMID:14520415
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:25605782
Biological Process	GO:0001736	establishment of planar polarity	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:25605782
Biological Process	GO:0045444	fat cell differentiation	Ttc8	IEP		Mouse	MGI:MGI:3794016|PMID:17379567
Biological Process	GO:0007369	gastrulation	ttc8	IMP	ZFIN:ZDB-MRPHLNO-060301-1	Zfish	PMID:20498079
Biological Process	GO:0001947	heart looping	ttc8	IMP	ZFIN:ZDB-MRPHLNO-060301-1	Zfish	PMID:16399798
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:25605782
Biological Process	GO:0046907	intracellular transport	ttc8	IMP	ZFIN:ZDB-MRPHLNO-060301-1	Zfish	PMID:16399798
Biological Process	GO:0070121	Kupffer's vesicle development	ttc8	IMP	ZFIN:ZDB-MRPHLNO-060301-1	Zfish	PMID:16399798
Biological Process	GO:0060972	left/right pattern formation	ttc8	IGI	ZFIN:ZDB-GENO-070305-2,ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0060972	left/right pattern formation	ttc8	IMP	ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0032402	melanosome transport	ttc8	IMP	ZFIN:ZDB-MRPHLNO-060301-1	Zfish	PMID:16399798
Biological Process	GO:1903251	multi-ciliated epithelial cell differentiation	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:25605782
Biological Process	GO:0035264	multicellular organism growth	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512
Biological Process	GO:0034260	negative regulation of GTPase activity	Ttc8	IMP		Mouse	PMID:23716571
Biological Process	GO:0001755	neural crest cell migration	ttc8	IMP	ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:18443298
Biological Process	GO:0021772	olfactory bulb development	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512
Biological Process	GO:0048840	otolith development	ttc8	IMP	ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0048840	otolith development	ttc8	IGI	ZFIN:ZDB-GENO-070305-2,ZFIN:ZDB-MRPHLNO-080918-2	Zfish	PMID:20643117
Biological Process	GO:0051877	pigment granule aggregation in cell center	ttc8	IMP	ZFIN:ZDB-MRPHLNO-060301-1	Zfish	PMID:16399798
Biological Process	GO:0072659	protein localization to plasma membrane	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:25605782
Biological Process	GO:0032880	regulation of protein localization	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512
Biological Process	GO:0051492	regulation of stress fiber assembly	Ttc8	IMP		Mouse	PMID:23716571
Biological Process	GO:0061326	renal tubule development	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512
Biological Process	GO:0007608	sensory perception of smell	Ttc8	IMP	MGI:MGI:5140723	Mouse	PMID:21646512

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern