Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TTK
  • Mouse genes Ttk
  • Rat genes Ttk
  • Zfish genes ttk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ttk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Ttk	IPI	PR:P35761	Mouse	PMID:21558374
Molecular Function	GO:0043515	kinetochore binding	Ttk	IMP	MGI:5056148	Mouse	PMID:25197064
Molecular Function	GO:0005515	protein binding	TTK	IPI	UniProtKB:P12270	Human	PMID:19273613
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	Ttk	IDA		Mouse	PMID:1375325
Cellular Component	GO:0005737	cytoplasm	TTK	IDA		Human	PMID:25468996
Cellular Component	GO:0000776	kinetochore	Ttk	IDA		Mouse	PMID:21558374
Cellular Component	GO:0016020	membrane	TTK	HDA		Human	PMID:19946888
Biological Process	GO:0060249	anatomical structure homeostasis	ttk	IMP	ZFIN:ZDB-GENO-020912-1	Zfish	PMID:18701543
Biological Process	GO:0016321	female meiosis chromosome segregation	Ttk	IMP	MGI:MGI:5056148	Mouse	PMID:21558374
Biological Process	GO:0016321	female meiosis chromosome segregation	ttk	IMP	ZFIN:ZDB-GENO-020912-1	Zfish	PMID:15231734
Biological Process	GO:0031101	fin regeneration	ttk	IMP	ZFIN:ZDB-GENO-020912-1	Zfish	PMID:12399306
Biological Process	GO:0031101	fin regeneration	ttk	IMP	ZFIN:ZDB-GENO-020912-1	Zfish	PMID:18701543
Biological Process	GO:0007060	male meiosis chromosome segregation	ttk	IMP	ZFIN:ZDB-GENO-020912-1	Zfish	PMID:15231734
Biological Process	GO:0098768	meiotic prometaphase I	Ttk	IMP	MGI:MGI:5056148	Mouse	PMID:21558374
Biological Process	GO:0033316	meiotic spindle assembly checkpoint signaling	Ttk	IMP	MGI:MGI:5056148	Mouse	PMID:21558374
Biological Process	GO:0007093	mitotic cell cycle checkpoint signaling	ttk	IMP	ZFIN:ZDB-GENO-020912-1	Zfish	PMID:15231734
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	Ttk	IMP	MGI:5056148	Mouse	PMID:25197064
Biological Process	GO:0001100	negative regulation of exit from mitosis	ttk	IMP		Zfish	PMID:12399306|ZFIN:ZDB-PUB-030102-3
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Ttk	IDA		Mouse	PMID:1375325
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Ttk	IDA		Mouse	PMID:1375325
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Ttk	IDA		Mouse	PMID:1375325
Biological Process	GO:0046777	protein autophosphorylation	Ttk	IDA		Mouse	PMID:1375325
Biological Process	GO:0034502	protein localization to chromosome	Ttk	IMP	MGI:MGI:5056148	Mouse	PMID:21558374
Biological Process	GO:0034501	protein localization to kinetochore	Ttk	IMP	MGI:MGI:5056148	Mouse	PMID:21558374
Biological Process	GO:1903096	protein localization to meiotic spindle midzone	Ttk	IMP	MGI:MGI:5056148	Mouse	PMID:21558374
Biological Process	GO:0071173	spindle assembly checkpoint signaling	Ttk	IMP		Mouse	PMID:32284991
Biological Process	GO:0042246	tissue regeneration	ttk	IMP		Zfish	PMID:12399306|ZFIN:ZDB-PUB-030102-3

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern