Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TTN
  • Mouse genes Ttn
  • Rat genes
  • Zfish genes ttn.1,ttn.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ttn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	TTN	IDA		Human	PMID:9501083
Molecular Function	GO:0042805	actinin binding	TTN	IPI	UniProtKB:P35609	Human	PMID:11846417
Molecular Function	GO:0042805	actinin binding	TTN	IDA		Human	PMID:9501083
Molecular Function	GO:0030506	ankyrin binding	Ttn	IPI	UniProtKB:Q9CR42|UniProtKB:Q9WV06	Mouse	MGI:MGI:3801259|PMID:18310072
Molecular Function	GO:0005509	calcium ion binding	TTN	IDA		Human	PMID:7607248
Molecular Function	GO:0005516	calmodulin binding	TTN	IPI	UniProtKB:P0DP23	Human	PMID:7607248
Molecular Function	GO:0005516	calmodulin binding	TTN	IPI	UniProtKB:P0DP24	Human	PMID:7607248
Molecular Function	GO:0019899	enzyme binding	TTN	IPI	UniProtKB:P20807	Human	PMID:18310072
Molecular Function	GO:0042802	identical protein binding	TTN	IPI	UniProtKB:Q8WZ42	Human	PMID:23414517
Molecular Function	GO:0042802	identical protein binding	TTN	IPI	UniProtKB:Q8WZ42	Human	PMID:9804419
Molecular Function	GO:0051371	muscle alpha-actinin binding	TTN	IPI	UniProtKB:P35609	Human	PMID:9501083
Molecular Function	GO:0002020	protease binding	TTN	IPI	UniProtKB:P20807	Human	PMID:9642272
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P12814	Human	PMID:11101506
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P35609	Human	PMID:11101506
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q5VST9	Human	PMID:11448995
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O15273	Human	PMID:11846417
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P35609	Human	PMID:11846417
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P20929	Human	PMID:12482578
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q15327	Human	PMID:14583192
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q86SG2	Human	PMID:14583192
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O15273	Human	PMID:15582318
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P20929	Human	PMID:16902413
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P35609	Human	PMID:16902413
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O15273	Human	PMID:16962094
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q969Q1	Human	PMID:18157088
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O15273	Human	PMID:19622741
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O75147	Human	PMID:20133654
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q5VST9	Human	PMID:20133654
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O75147	Human	PMID:20489725
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q5VST9	Human	PMID:20489725
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q9GZQ8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P20807	Human	PMID:20860623
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O15273	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O75923	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O75953	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P06733	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P20807	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P35609	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q13203	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q14324	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q5VST9	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q969Q1	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:O15061	Human	PMID:25447537
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q9GZQ8	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:Q9H492	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P0DP25	Human	PMID:7607248
Molecular Function	GO:0005515	protein binding	TTN	IPI	UniProtKB:P35609	Human	PMID:9501083
Molecular Function	GO:0005515	protein binding	Ttn	IPI	UniProtKB:Q70IV5	Mouse	MGI:MGI:5610068|PMID:25447537
Molecular Function	GO:0005515	protein binding	Ttn	IPI	UniProtKB:Q9BYV6	Mouse	PMID:15967462
Molecular Function	GO:0005515	protein binding	Ttn	IPI	PR:Q64691	Mouse	PMID:14741210
Molecular Function	GO:0005515	protein binding	Ttn	IPI	PR:Q64691	Mouse	PMID:15138196
Molecular Function	GO:0005515	protein binding	Ttn	IPI	PR:Q9CR42	Mouse	PMID:14741210
Molecular Function	GO:0019901	protein kinase binding	TTN	IPI	UniProtKB:Q13557	Human	PMID:23283722
Molecular Function	GO:0043621	protein self-association	TTN	IDA		Human	PMID:9804419
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TTN	IDA		Human	PMID:9804419
Molecular Function	GO:0004713	protein tyrosine kinase activity	TTN	IDA		Human	PMID:18765796
Molecular Function	GO:0008307	structural constituent of muscle	TTN	IMP		Human	PMID:11846417
Molecular Function	GO:0008307	structural constituent of muscle	TTN	IMP		Human	PMID:9817758
Molecular Function	GO:0008307	structural constituent of muscle	ttn.2	IMP	ZFIN:ZDB-GENO-980202-234	Zfish	PMID:11788825
Molecular Function	GO:0097493	structural molecule activity conferring elasticity	TTN	IDA		Human	PMID:9804419
Molecular Function	GO:0031433	telethonin binding	TTN	IPI	UniProtKB:O15273	Human	PMID:11846417
Molecular Function	GO:0031433	telethonin binding	TTN	IPI	UniProtKB:O15273	Human	PMID:15582318
Cellular Component	GO:0031672	A band	Ttn	IDA		Mouse	PMID:16481394
Cellular Component	GO:0031672	A band	Ttn	IDA		Mouse	PMID:16702235
Cellular Component	GO:0005814	centriole	ttn.2	IDA		Zfish	PMID:22985877
Cellular Component	GO:0000794	condensed nuclear chromosome	TTN	IDA		Human	PMID:9548712
Cellular Component	GO:0005737	cytoplasm	ttn.2	IDA		Zfish	PMID:22985877
Cellular Component	GO:0070062	extracellular exosome	TTN	HDA		Human	PMID:19056867
Cellular Component	GO:0031674	I band	TTN	IDA		Human	PMID:9817758
Cellular Component	GO:0031674	I band	Ttn	IDA		Mouse	PMID:16481394
Cellular Component	GO:0031674	I band	Ttn	IDA		Mouse	PMID:16702235
Cellular Component	GO:0031430	M band	Ttn	IDA		Mouse	PMID:16702235
Cellular Component	GO:0031430	M band	Ttn	IDA		Mouse	PMID:17360664
Cellular Component	GO:0031430	M band	Ttn	IDA		Mouse	PMID:15138196
Cellular Component	GO:0005634	nucleus	ttn.2	IDA		Zfish	PMID:22985877
Cellular Component	GO:0030017	sarcomere	Ttn	IDA		Mouse	PMID:12651156
Cellular Component	GO:1990733	titin-telethonin complex	TTN	IPI		Human	PMID:16407954
Cellular Component	GO:0030018	Z disc	TTN	IDA		Human	PMID:19850579
Cellular Component	GO:0030018	Z disc	TTN	IDA		Human	PMID:9501083
Cellular Component	GO:0030018	Z disc	TTN	IDA		Human	PMID:9817758
Cellular Component	GO:0030018	Z disc	Ttn	IDA		Mouse	PMID:15138196
Cellular Component	GO:0030018	Z disc	Ttn	IDA		Mouse	PMID:16481394
Biological Process	GO:0007512	adult heart development	Ttn	IMP	MGI:MGI:3654306	Mouse	PMID:16702235
Biological Process	GO:0055013	cardiac muscle cell development	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0060048	cardiac muscle contraction	TTN	IMP		Human	PMID:11846417
Biological Process	GO:0003300	cardiac muscle hypertrophy	TTN	IMP		Human	PMID:11846417
Biological Process	GO:0048738	cardiac muscle tissue development	ttn.2	IMP	ZFIN:ZDB-GENO-160526-5	Zfish	PMID:26473617
Biological Process	GO:0048738	cardiac muscle tissue development	ttn.2	IMP	ZFIN:ZDB-GENO-160526-7	Zfish	PMID:26473617
Biological Process	GO:0048738	cardiac muscle tissue development	ttn.2	IMP	ZFIN:ZDB-GENO-160526-6	Zfish	PMID:26473617
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	Ttn	IMP	MGI:MGI:3763610	Mouse	PMID:17360664
Biological Process	GO:0055003	cardiac myofibril assembly	TTN	IMP		Human	PMID:11846417
Biological Process	GO:0055003	cardiac myofibril assembly	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0055003	cardiac myofibril assembly	Ttn	IMP	MGI:MGI:3654306	Mouse	PMID:16702235
Biological Process	GO:0000902	cell morphogenesis	ttn.2	IMP	ZFIN:ZDB-GENO-980202-234	Zfish	PMID:11788825
Biological Process	GO:0035995	detection of muscle stretch	TTN	IDA		Human	PMID:18765796
Biological Process	GO:0043056	forward locomotion	Ttn	IMP	MGI:MGI:1856953	Mouse	PMID:16115818
Biological Process	GO:0060047	heart contraction	ttn.2	IMP	ZFIN:ZDB-MRPHLNO-070618-1	Zfish	PMID:17170364
Biological Process	GO:0060047	heart contraction	ttn.2	IMP	ZFIN:ZDB-MRPHLNO-070618-2	Zfish	PMID:17170364
Biological Process	GO:0007507	heart development	Ttn	IEP		Mouse	MGI:MGI:1314551|PMID:9817758
Biological Process	GO:0007507	heart development	ttn.2	IMP	ZFIN:ZDB-GENO-170308-3	Zfish	PMID:27836965
Biological Process	GO:0007507	heart development	ttn.2	IMP	ZFIN:ZDB-GENO-170308-4	Zfish	PMID:27836965
Biological Process	GO:0060419	heart growth	Ttn	IMP	MGI:MGI:3763610	Mouse	PMID:17360664
Biological Process	GO:0003007	heart morphogenesis	Ttn	IMP	MGI:MGI:3654306	Mouse	PMID:16702235
Biological Process	GO:0001701	in utero embryonic development	Ttn	IMP	MGI:MGI:3654306	Mouse	PMID:16702235
Biological Process	GO:0007076	mitotic chromosome condensation	TTN	IEP		Human	PMID:9548712
Biological Process	GO:0006936	muscle contraction	Ttn	IMP	MGI:MGI:1856953	Mouse	PMID:16115818
Biological Process	GO:0030239	myofibril assembly	ttn.2	IGI	ZFIN:ZDB-GENE-030616-413	Zfish	PMID:27836965
Biological Process	GO:0030239	myofibril assembly	ttn.1	IGI	ZFIN:ZDB-GENE-030113-2	Zfish	PMID:27836965
Biological Process	GO:0010628	positive regulation of gene expression	TTN	IGI	UniProtKB:P52179	Human	PMID:25152160
Biological Process	GO:0010628	positive regulation of gene expression	TTN	IMP		Human	PMID:25152160
Biological Process	GO:0050714	positive regulation of protein secretion	TTN	IGI	UniProtKB:P52179	Human	PMID:25152160
Biological Process	GO:0050714	positive regulation of protein secretion	TTN	IMP		Human	PMID:25152160
Biological Process	GO:0010737	protein kinase A signaling	TTN	IMP		Human	PMID:25152160
Biological Process	GO:0050790	regulation of catalytic activity	TTN	IMP		Human	PMID:9804419
Biological Process	GO:0045859	regulation of protein kinase activity	TTN	IMP		Human	PMID:9804419
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle	Ttn	IMP		Mouse	MGI:MGI:5508699|PMID:23283722
Biological Process	GO:0051592	response to calcium ion	TTN	IDA		Human	PMID:7607248
Biological Process	GO:0045214	sarcomere organization	TTN	IMP		Human	PMID:11846417
Biological Process	GO:0045214	sarcomere organization	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0045214	sarcomere organization	Ttn	IMP		Mouse	PMID:17360664
Biological Process	GO:0045214	sarcomere organization	Ttn	IMP	MGI:MGI:3654306	Mouse	PMID:16702235
Biological Process	GO:0045214	sarcomere organization	ttn.2	IMP	ZFIN:ZDB-GENO-190227-11	Zfish	PMID:30333491
Biological Process	GO:0045214	sarcomere organization	ttn.2	IMP	ZFIN:ZDB-GENO-980202-234	Zfish	PMID:11788825
Biological Process	GO:0045214	sarcomere organization	ttn.2	IMP	ZFIN:ZDB-MRPHLNO-070618-1	Zfish	PMID:17170364
Biological Process	GO:0045214	sarcomere organization	ttn.2	IMP	ZFIN:ZDB-GENO-190227-10	Zfish	PMID:30333491
Biological Process	GO:0045214	sarcomere organization	ttn.2	IMP	ZFIN:ZDB-MRPHLNO-070618-2	Zfish	PMID:17170364
Biological Process	GO:0048769	sarcomerogenesis	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0048769	sarcomerogenesis	ttn.2	IMP	ZFIN:ZDB-GENO-170308-3	Zfish	PMID:27836965
Biological Process	GO:0048769	sarcomerogenesis	ttn.2	IMP	ZFIN:ZDB-GENO-170308-4	Zfish	PMID:27836965
Biological Process	GO:0048769	sarcomerogenesis	ttn.2	IGI	ZFIN:ZDB-GENE-030616-413	Zfish	PMID:27836965
Biological Process	GO:0048769	sarcomerogenesis	ttn.1	IGI	ZFIN:ZDB-GENE-030113-2	Zfish	PMID:27836965
Biological Process	GO:0048769	sarcomerogenesis	ttn.1	IMP	ZFIN:ZDB-GENO-170308-5	Zfish	PMID:27836965
Biological Process	GO:0030241	skeletal muscle myosin thick filament assembly	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0030240	skeletal muscle thin filament assembly	TTN	IMP		Human	PMID:9817758
Biological Process	GO:0007519	skeletal muscle tissue development	ttn.2	IMP	ZFIN:ZDB-GENO-160526-5	Zfish	PMID:26473617
Biological Process	GO:0007519	skeletal muscle tissue development	ttn.2	IMP	ZFIN:ZDB-GENO-160526-7	Zfish	PMID:26473617
Biological Process	GO:0007519	skeletal muscle tissue development	ttn.2	IGI	ZFIN:ZDB-GENO-160526-2,ZFIN:ZDB-MRPHLNO-071106-2	Zfish	PMID:26473617
Biological Process	GO:0007519	skeletal muscle tissue development	ttn.2	IMP	ZFIN:ZDB-GENO-160526-6	Zfish	PMID:26473617
Biological Process	GO:0007519	skeletal muscle tissue development	ttn.1	IGI	ZFIN:ZDB-GENO-160526-2,ZFIN:ZDB-MRPHLNO-071106-2	Zfish	PMID:26473617
Biological Process	GO:0014866	skeletal myofibril assembly	ttn.1	IMP	ZFIN:ZDB-MRPHLNO-071106-2	Zfish	PMID:17678642
Biological Process	GO:0014866	skeletal myofibril assembly	ttn.1	IMP	ZFIN:ZDB-MRPHLNO-071106-3	Zfish	PMID:17678642
Biological Process	GO:0001756	somitogenesis	Ttn	IEP		Mouse	MGI:MGI:1314551|PMID:9817758
Biological Process	GO:0055002	striated muscle cell development	Ttn	IMP	MGI:MGI:1856953	Mouse	PMID:16115818
Biological Process	GO:0071688	striated muscle myosin thick filament assembly	ttn.2	IGI	ZFIN:ZDB-GENE-030616-413	Zfish	PMID:27836965
Biological Process	GO:0071688	striated muscle myosin thick filament assembly	ttn.1	IGI	ZFIN:ZDB-GENE-030113-2	Zfish	PMID:27836965
Biological Process	GO:0021591	ventricular system development	Ttn	IMP	MGI:MGI:3763610	Mouse	PMID:17360664

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern