Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Twist1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TWIST1
- Mouse genes Twist1
- Rat genes Twist1
- Zfish genes twist1a,twist1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Twist1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	TWIST1	IPI	UniProtKB:P15923-1	Human	PMID:10749989
Molecular Function	GO:0043425	bHLH transcription factor binding	Twist1	IPI	UniProtKB:P15806	Mouse	MGI:MGI:6508503\|PMID:23395635
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	twist1b	IPI	ZFIN:ZDB-GENE-980526-426	Zfish	PMID:22589745
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Twist1	IDA		Mouse	MGI:MGI:4457247\|PMID:17893140
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	TWIST1	IDA		Human	PMID:17332325
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TWIST1	IPI	UniProtKB:P20719	Human	PMID:15545268
Molecular Function	GO:0070888	E-box binding	TWIST1	IDA		Human	PMID:17332325
Molecular Function	GO:0070888	E-box binding	TWIST1	IDA		Human	PMID:20804746
Molecular Function	GO:0070888	E-box binding	Twist1	IDA		Mouse	MGI:MGI:4838344\|PMID:20804746
Molecular Function	GO:0070888	E-box binding	Twist1	IDA		Mouse	MGI:MGI:3623529\|PMID:16502419
Molecular Function	GO:0070888	E-box binding	Twist1	IMP		Mouse	MGI:MGI:5528778\|PMID:24011070
Molecular Function	GO:0042826	histone deacetylase binding	Twist1	IDA		Mouse	MGI:MGI:3843109\|PMID:19345188
Molecular Function	GO:0042802	identical protein binding	Twist1	IPI	PR:P26687	Mouse	PMID:16502419
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15923-1	Human	PMID:10749989
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15923-1	Human	PMID:11248247
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P04637	Human	PMID:18504427
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:Q92831	Human	PMID:18504427
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15036	Human	PMID:18598946
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15884	Human	PMID:19534813
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:Q9NQR1	Human	PMID:21983900
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P04637	Human	PMID:22975381
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:O60885	Human	PMID:24525235
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:O60885-1	Human	PMID:24525235
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:Q92993	Human	PMID:24525235
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P04637	Human	PMID:25402006
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15884	Human	PMID:25402006
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15884	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:Q9UN86	Human	PMID:25893917
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P15884	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TWIST1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Twist1	IPI	UniProtKB:P04637	Mouse	MGI:MGI:5448103\|PMID:22975381
Molecular Function	GO:0005515	protein binding	Twist1	IPI	UniProtKB:Q9UN86	Mouse	MGI:MGI:5914299\|PMID:25893917
Molecular Function	GO:0005515	protein binding	Twist1	IPI	PR:P15806	Mouse	PMID:16502419
Molecular Function	GO:0019904	protein domain specific binding	Twist1	IPI	PR:Q08775	Mouse	PMID:15030764
Molecular Function	GO:0042803	protein homodimerization activity	Twist1	IDA		Mouse	MGI:MGI:3623529\|PMID:16502419
Molecular Function	GO:0001221	transcription coregulator binding	Twist1	IPI	UniProtKB:O70343	Mouse	MGI:MGI:3843109\|PMID:19345188
Cellular Component	GO:0005634	nucleus	TWIST1	IDA		Human	PMID:10749989
Cellular Component	GO:0005634	nucleus	TWIST1	IDA		Human	PMID:15545268
Cellular Component	GO:0005634	nucleus	Twist1	IDA		Mouse	PMID:16100003
Cellular Component	GO:0005634	nucleus	Twist1	IDA		Rat	PMID:19893041\|RGD:5131599
Biological Process	GO:0003180	aortic valve morphogenesis	TWIST1	IMP		Human	PMID:20804746
Biological Process	GO:0003180	aortic valve morphogenesis	Twist1	IMP		Mouse	MGI:MGI:4838344\|PMID:20804746
Biological Process	GO:0003181	atrioventricular valve morphogenesis	twist1b	IGI	ZFIN:ZDB-GENO-210512-2	Zfish	PMID:32070236
Biological Process	GO:0060348	bone development	Twist1	IEP		Rat	PMID:8773900\|RGD:5131604
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:18539270
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:18539270
Biological Process	GO:2000793	cell proliferation involved in heart valve development	TWIST1	IMP		Human	PMID:20804746
Biological Process	GO:2000793	cell proliferation involved in heart valve development	Twist1	IMP		Mouse	MGI:MGI:4838344\|PMID:20804746
Biological Process	GO:0071363	cellular response to growth factor stimulus	Twist1	IEP		Rat	PMID:19893041\|RGD:5131599
Biological Process	GO:0071456	cellular response to hypoxia	TWIST1	IMP		Human	PMID:18297062
Biological Process	GO:0071456	cellular response to hypoxia	Twist1	IMP		Mouse	MGI:MGI:5284765\|PMID:18297062
Biological Process	GO:0060363	cranial suture morphogenesis	Twist1	IMP		Mouse	MGI:MGI:3623529\|PMID:16502419
Biological Process	GO:0060363	cranial suture morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:15030764
Biological Process	GO:0060363	cranial suture morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:12221714
Biological Process	GO:0060363	cranial suture morphogenesis	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0009953	dorsal/ventral pattern formation	twist1b	IGI	ZFIN:ZDB-MRPHLNO-061127-3,ZFIN:ZDB-MRPHLNO-111209-7	Zfish	PMID:22087291
Biological Process	GO:0009953	dorsal/ventral pattern formation	twist1b	IGI	ZFIN:ZDB-MRPHLNO-061127-3,ZFIN:ZDB-MRPHLNO-111209-6	Zfish	PMID:22087291
Biological Process	GO:0060900	embryonic camera-type eye formation	TWIST1	IMP		Human	PMID:17070479
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	TWIST1	IMP		Human	PMID:8988166
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	TWIST1	IMP		Human	PMID:8988167
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Twist1	IMP		Mouse	MGI:MGI:1100098\|PMID:8988167
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Twist1	IGI	MGI:MGI:99829	Mouse	PMID:15030764
Biological Process	GO:0042733	embryonic digit morphogenesis	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:12175489
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Twist1	IMP		Mouse	MGI:MGI:1100098\|PMID:8988167
Biological Process	GO:0030326	embryonic limb morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:12142027
Biological Process	GO:0030326	embryonic limb morphogenesis	Twist1	IMP	MGI:MGI:2157489	Mouse	PMID:11350121
Biological Process	GO:0030326	embryonic limb morphogenesis	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0003203	endocardial cushion morphogenesis	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:18539270
Biological Process	GO:0097009	energy homeostasis	Twist1	IDA		Mouse	MGI:MGI:3843109\|PMID:19345188
Biological Process	GO:0061029	eyelid development in camera-type eye	TWIST1	IMP		Human	PMID:17070479
Biological Process	GO:0035137	hindlimb morphogenesis	Twist1	IMP	MGI:MGI:2157489	Mouse	PMID:10700192
Biological Process	GO:0001701	in utero embryonic development	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0010934	macrophage cytokine production	Twist1	IGI	MGI:MGI:104685	Mouse	PMID:16831897
Biological Process	GO:0003183	mitral valve morphogenesis	Twist1	IMP		Mouse	MGI:MGI:4838344\|PMID:20804746
Biological Process	GO:0043066	negative regulation of apoptotic process	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:12175489
Biological Process	GO:0043066	negative regulation of apoptotic process	Twist1	IDA		Rat	PMID:10485844\|RGD:634726
Biological Process	GO:0043066	negative regulation of apoptotic process	Twist1	IMP		Rat	PMID:19893041\|RGD:5131599
Biological Process	GO:0045596	negative regulation of cell differentiation	Twist1	IDA		Mouse	MGI:MGI:1201268\|PMID:9520323
Biological Process	GO:2000773	negative regulation of cellular senescence	TWIST1	IMP		Human	PMID:17690110
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	TWIST1	IMP		Human	PMID:17690110
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TWIST1	IDA		Human	PMID:25981568
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Twist1	IDA		Mouse	MGI:MGI:5559671\|PMID:14645221
Biological Process	GO:2000780	negative regulation of double-strand break repair	TWIST1	IMP		Human	PMID:17690110
Biological Process	GO:0035067	negative regulation of histone acetylation	Twist1	IDA		Mouse	MGI:MGI:3843109\|PMID:19345188
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Twist1	IGI	MGI:MGI:104685	Mouse	PMID:16831897
Biological Process	GO:0044092	negative regulation of molecular function	Twist1	IDA		Mouse	PMID:15030764
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	TWIST1	IMP		Human	PMID:16888803
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Twist1	IDA		Mouse	PMID:15030764
Biological Process	GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity	Twist1	IDA		Mouse	MGI:MGI:3843109\|PMID:19345188
Biological Process	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	Twist1	IDA		Mouse	MGI:MGI:3843109\|PMID:19345188
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	TWIST1	IMP		Human	PMID:17003487
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	Twist1	IDA		Mouse	PMID:7958419
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	Twist1	IDA		Mouse	PMID:7664846
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	Twist1	IDA		Mouse	MGI:MGI:1201268\|PMID:9520323
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TWIST1	IMP		Human	PMID:17690110
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist1	IDA		Mouse	MGI:MGI:3843109\|PMID:19345188
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist1	IDA		Mouse	MGI:MGI:3623529\|PMID:16502419
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist1	IDA		Mouse	PMID:7664846
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Twist1	IGI	MGI:MGI:104685	Mouse	PMID:16831897
Biological Process	GO:0001843	neural tube closure	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:7729687
Biological Process	GO:0001764	neuron migration	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:15162501
Biological Process	GO:0042476	odontogenesis	Twist1	IEP		Rat	PMID:11330859\|RGD:5131603
Biological Process	GO:0001503	ossification	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0001649	osteoblast differentiation	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:15030764
Biological Process	GO:0001649	osteoblast differentiation	Twist1	IMP	MGI:MGI:3038818	Mouse	PMID:15030764
Biological Process	GO:0060037	pharyngeal system development	twist1a	IGI	ZFIN:ZDB-MRPHLNO-120523-1,ZFIN:ZDB-MRPHLNO-120523-2	Zfish	PMID:22589745
Biological Process	GO:0060037	pharyngeal system development	twist1b	IGI	ZFIN:ZDB-MRPHLNO-120523-1,ZFIN:ZDB-MRPHLNO-120523-2	Zfish	PMID:22589745
Biological Process	GO:0030335	positive regulation of cell migration	TWIST1	IMP		Human	PMID:17332325
Biological Process	GO:2000147	positive regulation of cell motility	Twist1	IMP		Mouse	MGI:MGI:5284780\|PMID:17332324
Biological Process	GO:2000144	positive regulation of DNA-templated transcription initiation	TWIST1	IDA		Human	PMID:17332325
Biological Process	GO:2000802	positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	Twist1	IDA		Mouse	MGI:MGI:4838344\|PMID:20804746
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Twist1	IMP		Rat	PMID:19276370\|RGD:5131601
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	TWIST1	IMP		Human	PMID:18297062
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Twist1	IMP		Mouse	MGI:MGI:5284780\|PMID:17332324
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Twist1	IMP		Mouse	MGI:MGI:5284765\|PMID:18297062
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Twist1	IMP		Mouse	MGI:MGI:4838344\|PMID:20804746
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	TWIST1	IMP		Human	PMID:20007935
Biological Process	GO:0010628	positive regulation of gene expression	TWIST1	IMP		Human	PMID:17003487
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TWIST1	IMP		Human	PMID:20007935
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	TWIST1	IMP		Human	PMID:20007935
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TWIST1	IMP		Human	PMID:12270142
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TWIST1	IDA		Human	PMID:17332325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Twist1	IDA		Mouse	MGI:MGI:4838344\|PMID:20804746
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Twist1	IDA		Mouse	MGI:MGI:4457247\|PMID:17893140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Twist1	IDA		Mouse	PMID:24011070
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	TWIST1	IMP		Human	PMID:12270142
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	TWIST1	IMP		Human	PMID:20007935
Biological Process	GO:0030500	regulation of bone mineralization	TWIST1	IMP		Human	PMID:19597909
Biological Process	GO:0030500	regulation of bone mineralization	twist1b	IMP	ZFIN:ZDB-MRPHLNO-111209-6	Zfish	PMID:22087291
Biological Process	GO:0030500	regulation of bone mineralization	twist1b	IMP	ZFIN:ZDB-MRPHLNO-111209-7	Zfish	PMID:22087291
Biological Process	GO:0060021	roof of mouth development	Twist1	IEP		Rat	PMID:11330859\|RGD:5131603
Biological Process	GO:0002040	sprouting angiogenesis	twist1a	IGI	ZFIN:ZDB-GENE-050417-357	Zfish	PMID:27245171
Biological Process	GO:0002040	sprouting angiogenesis	twist1b	IGI	ZFIN:ZDB-GENE-000210-6	Zfish	PMID:27245171
Biological Process	GO:0048863	stem cell differentiation	Twist1	IMP	MGI:MGI:1857265	Mouse	PMID:12142027
Biological Process	GO:0032640	tumor necrosis factor production	Twist1	IGI	MGI:MGI:104685	Mouse	PMID:16831897

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.