Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TWIST2
  • Mouse genes Twist2
  • Rat genes Twist2
  • Zfish genes twist2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Twist2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Twist2	IDA		Mouse	PMID:16831897
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Twist2	IDA		Mouse	PMID:7589808
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P15036	Human	PMID:18598946
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:Q99081	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:Q9BSQ5	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P15884	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P15923-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:Q9BZE0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P01023	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TWIST2	IPI	UniProtKB:Q9UBB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Twist2	IPI	UniProtKB:Q08775	Mouse	MGI:MGI:4839410|PMID:20655471
Molecular Function	GO:0005515	protein binding	Twist2	IPI	PR:Q9WTN3	Mouse	PMID:14654692
Molecular Function	GO:0005515	protein binding	Twist2	IPI	PR:Q03347	Mouse	PMID:19090621
Molecular Function	GO:0019904	protein domain specific binding	Twist2	IPI	PR:Q08775	Mouse	PMID:15030764
Molecular Function	GO:0008134	transcription factor binding	Twist2	IDA		Mouse	PMID:14654692
Cellular Component	GO:0005737	cytoplasm	TWIST2	IDA		Human	PMID:11062344
Cellular Component	GO:0005730	nucleolus	TWIST2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TWIST2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TWIST2	IDA		Human	PMID:11062344
Cellular Component	GO:0005667	transcription regulator complex	Twist2	IPI	PR:P15806	Mouse	PMID:7589808
Biological Process	GO:0008283	cell population proliferation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:19090621
Biological Process	GO:0061303	cornea development in camera-type eye	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:20574024
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Twist2	IGI	MGI:MGI:99829	Mouse	PMID:15030764
Biological Process	GO:0060325	face morphogenesis	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:20691403
Biological Process	GO:0060325	face morphogenesis	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:20574024
Biological Process	GO:0043616	keratinocyte proliferation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:20574024
Biological Process	GO:0010934	macrophage cytokine production	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:16831897
Biological Process	GO:0010934	macrophage cytokine production	Twist2	IGI	MGI:MGI:98872	Mouse	PMID:16831897
Biological Process	GO:0030099	myeloid cell differentiation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:19090621
Biological Process	GO:0043066	negative regulation of apoptotic process	Twist2	IDA		Rat	PMID:10485844|RGD:634726
Biological Process	GO:0008285	negative regulation of cell population proliferation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:19090621
Biological Process	GO:0043392	negative regulation of DNA binding	Twist2	IDA		Mouse	PMID:14654692
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Twist2	IDA		Mouse	MGI:MGI:77180|PMID:7589808
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Twist2	IGI	MGI:MGI:98872	Mouse	PMID:16831897
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:16831897
Biological Process	GO:0044092	negative regulation of molecular function	Twist2	IDA		Mouse	PMID:15030764
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:19090621
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	TWIST2	IDA		Human	PMID:11062344
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:15030764
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist2	IDA		Mouse	PMID:16831897
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist2	IGI	MGI:MGI:99480	Mouse	PMID:19090621
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist2	IGI	MGI:MGI:108086	Mouse	PMID:14654692
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist2	IGI	MGI:MGI:107606	Mouse	PMID:14654692
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Twist2	IGI	MGI:MGI:99852	Mouse	PMID:19090621
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Twist2	IGI	MGI:MGI:98872	Mouse	PMID:16831897
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:16831897
Biological Process	GO:0001649	osteoblast differentiation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:15030764
Biological Process	GO:0030335	positive regulation of cell migration	TWIST2	IGI	RNAcentral:URS000040780F_9606	Human	PMID:24171926
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:20574024
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Twist2	IDA		Mouse	PMID:7589808
Biological Process	GO:0032868	response to insulin	Twist2	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0014070	response to organic cyclic compound	Twist2	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0032640	tumor necrosis factor production	Twist2	IMP	MGI:MGI:3044412	Mouse	PMID:16831897
Biological Process	GO:0032640	tumor necrosis factor production	Twist2	IGI	MGI:MGI:98872	Mouse	PMID:16831897

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern