Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TWSG1
  • Mouse genes Twsg1
  • Rat genes Twsg1
  • Zfish genes twsg1a,twsg1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Twsg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008201	heparin binding	Twsg1	IDA		Mouse	PMID:15381701
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:Q8TBE3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:Q9HCJ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:Q9NZD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TWSG1	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Twsg1	IPI	UniProtKB:P21275	Mouse	PMID:15381701
Molecular Function	GO:0005515	protein binding	Twsg1	IPI	UniProtKB:Q9Z0E2	Mouse	PMID:15381701
Molecular Function	GO:0005515	protein binding	Twsg1	IPI	PR:Q9Z0E2	Mouse	PMID:15381701
Molecular Function	GO:0005515	protein binding	Twsg1	IPI	PR:P23359	Mouse	PMID:15843411
Molecular Function	GO:0005515	protein binding	Twsg1	IPI	PR:P21275	Mouse	PMID:15381701
Molecular Function	GO:0050431	transforming growth factor beta binding	TWSG1	IDA		Human	PMID:17164348
Cellular Component	GO:0005615	extracellular space	Twsg1	IDA		Mouse	PMID:15780974
Biological Process	GO:0001568	blood vessel development	twsg1a	IGI	ZFIN:ZDB-GENE-020812-3	Zfish	PMID:15525664
Biological Process	GO:0001568	blood vessel development	twsg1b	IMP	ZFIN:ZDB-MRPHLNO-050119-5	Zfish	PMID:29473997
Biological Process	GO:0001568	blood vessel development	twsg1b	IMP		Zfish	PMID:15525664
Biological Process	GO:0030509	BMP signaling pathway	Twsg1	IGI	MGI:MGI:88180	Mouse	PMID:14681194
Biological Process	GO:0043010	camera-type eye development	Twsg1	IGI	MGI:MGI:88180	Mouse	PMID:14681194
Biological Process	GO:0002062	chondrocyte differentiation	Twsg1	IMP	MGI:MGI:3044357	Mouse	PMID:14681194
Biological Process	GO:0048264	determination of ventral identity	twsg1b	IGI	ZFIN:ZDB-GENE-990603-9	Zfish	PMID:15525664
Biological Process	GO:0048264	determination of ventral identity	twsg1b	IGI	ZFIN:ZDB-GENO-980202-1488	Zfish	PMID:15525664
Biological Process	GO:0048264	determination of ventral identity	twsg1b	IGI	ZFIN:ZDB-GENE-980526-474	Zfish	PMID:15525664
Biological Process	GO:0048264	determination of ventral identity	twsg1b	IMP		Zfish	PMID:15525664
Biological Process	GO:0048264	determination of ventral identity	twsg1b	IGI	ZFIN:ZDB-GENO-001220-1	Zfish	PMID:15525664
Biological Process	GO:0009790	embryo development	Twsg1	IMP	MGI:MGI:2655736	Mouse	PMID:15013800
Biological Process	GO:0035162	embryonic hemopoiesis	twsg1b	IGI	ZFIN:ZDB-GENO-060811-12	Zfish	PMID:15604098
Biological Process	GO:0035162	embryonic hemopoiesis	twsg1b	IMP	ZFIN:ZDB-MRPHLNO-050119-5	Zfish	PMID:15604098
Biological Process	GO:0030900	forebrain development	Twsg1	IGI	MGI:MGI:88180	Mouse	PMID:14681194
Biological Process	GO:0030900	forebrain development	Twsg1	IMP	MGI:MGI:2655736	Mouse	PMID:15013800
Biological Process	GO:0030097	hemopoiesis	Twsg1	IMP	MGI:MGI:2655736	Mouse	PMID:12665593
Biological Process	GO:0001707	mesoderm formation	Twsg1	IGI	MGI:MGI:103302	Mouse	PMID:15843411
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Twsg1	IMP	MGI:MGI:2655736	Mouse	PMID:12665593
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Twsg1	IDA		Mouse	PMID:15780974
Biological Process	GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	TWSG1	IDA		Human	PMID:17164348
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	TWSG1	IDA		Human	PMID:17164348
Biological Process	GO:0001818	negative regulation of cytokine production	TWSG1	IDA		Human	PMID:17164348
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Twsg1	IDA		Mouse	PMID:15780974
Biological Process	GO:0001503	ossification	Twsg1	IMP	MGI:MGI:2655736	Mouse	PMID:12665593
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Twsg1	IMP	MGI:MGI:2655736	Mouse	PMID:12665593
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	twsg1b	IGI	ZFIN:ZDB-GENO-980202-1488	Zfish	PMID:15525664
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	TWSG1	IDA		Human	PMID:17164348
Biological Process	GO:0045765	regulation of angiogenesis	twsg1b	IGI	ZFIN:ZDB-MRPHLNO-050119-5,ZFIN:ZDB-MRPHLNO-071005-1	Zfish	PMID:23641068
Biological Process	GO:0045765	regulation of angiogenesis	twsg1b	IMP	ZFIN:ZDB-MRPHLNO-050119-5	Zfish	PMID:23641068
Biological Process	GO:0030510	regulation of BMP signaling pathway	twsg1b	IMP	ZFIN:ZDB-MRPHLNO-050119-5	Zfish	PMID:15604098
Biological Process	GO:0030510	regulation of BMP signaling pathway	twsg1b	IMP	ZFIN:ZDB-MRPHLNO-050119-9	Zfish	PMID:15604098
Biological Process	GO:0007435	salivary gland morphogenesis	Twsg1	IMP	MGI:MGI:3830633	Mouse	PMID:16289463
Biological Process	GO:0009888	tissue development	Twsg1	IGI	MGI:MGI:88180	Mouse	PMID:14681194
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TWSG1	IDA		Human	PMID:17164348

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern