Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TXN
  • Mouse genes Txn1
  • Rat genes Txn1
  • Zfish genes txn,zgc:56493
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Txn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Txn1	IPI	RGD:732119	Rat	PMID:20536427|RGD:5133715
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9H3M7	Human	PMID:10814541
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P27695	Human	PMID:11118054
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P42574	Human	PMID:15246877
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q99683	Human	PMID:15246877
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q92905	Human	PMID:15480426
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P00533	Human	PMID:15657067
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9H3M7	Human	PMID:17260951
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P32119	Human	PMID:17557078
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P42574	Human	PMID:17606900
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:D0ZRB2	Human	PMID:19690162
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q8ZQQ2	Human	PMID:19690162
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q99683	Human	PMID:19805025
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q92905	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q99683	Human	PMID:21771788
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q99836	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P18031	Human	PMID:24976139
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P32119	Human	PMID:25402766
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9H3M7	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P12814	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P19883	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P37198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9BXU3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9GZT8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9H3M7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9UJW9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q9Y605	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:X5D778	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P01023	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P04406	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P07900	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P19404	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P23560-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P31749	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P51608	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q14114-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TXN	IPI	UniProtKB:P27695	Human	PMID:9108029
Molecular Function	GO:0005515	protein binding	Txn1	IPI	PR:Q8BG60	Mouse	PMID:18555775
Molecular Function	GO:0042803	protein homodimerization activity	TXN	IDA		Human	PMID:17260951
Molecular Function	GO:0042803	protein homodimerization activity	TXN	IDA		Human	PMID:9369469
Molecular Function	GO:0047134	protein-disulfide reductase (NAD(P)) activity	TXN	IDA		Human	PMID:17182577
Molecular Function	GO:0015035	protein-disulfide reductase activity	TXN	IDA		Human	PMID:17182577
Molecular Function	GO:0015035	protein-disulfide reductase activity	TXN	IDA		Human	PMID:19032234
Molecular Function	GO:0015035	protein-disulfide reductase activity	TXN	IDA		Human	PMID:2176490
Molecular Function	GO:0015035	protein-disulfide reductase activity	Txn1	IDA		Mouse	PMID:18555775
Molecular Function	GO:0003723	RNA binding	TXN	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	TXN	HDA		Human	PMID:22681889
Cellular Component	GO:0030424	axon	Txn1	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005737	cytoplasm	TXN	IDA		Human	PMID:9108029
Cellular Component	GO:0005737	cytoplasm	Txn1	IDA		Mouse	PMID:11213470
Cellular Component	GO:0005737	cytoplasm	Txn1	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005829	cytosol	TXN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Txn1	IDA		Mouse	PMID:18555775
Cellular Component	GO:0005829	cytosol	Txn1	IDA		Rat	PMID:20536427|RGD:5133715
Cellular Component	GO:0030425	dendrite	Txn1	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0070062	extracellular exosome	TXN	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TXN	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	TXN	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	TXN	IDA		Human	PMID:1332947
Cellular Component	GO:0005739	mitochondrion	Txn1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Txn1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	Txn1	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005654	nucleoplasm	TXN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TXN	IDA		Human	PMID:9108029
Cellular Component	GO:0005634	nucleus	Txn1	IDA		Mouse	PMID:18555775
Cellular Component	GO:0005634	nucleus	Txn1	IDA		Mouse	PMID:11213470
Biological Process	GO:0045454	cell redox homeostasis	TXN	IDA		Human	PMID:2176490
Biological Process	GO:0045454	cell redox homeostasis	TXN	IMP		Human	PMID:9108029
Biological Process	GO:0045454	cell redox homeostasis	Txn1	IDA		Mouse	PMID:18555775
Biological Process	GO:0071236	cellular response to antibiotic	Txn1	IEP		Rat	PMID:21184825|RGD:5133706
Biological Process	GO:0071333	cellular response to glucose stimulus	Txn1	IEP		Rat	PMID:20453393|RGD:5133719
Biological Process	GO:0071455	cellular response to hyperoxia	Txn1	IEP		Rat	PMID:21505996|RGD:5133704
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Txn1	IEP		Rat	PMID:20453393|RGD:5133719
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	TXN	IGI	UniProtKB:Q99497	Human	PMID:22492997
Biological Process	GO:0046826	negative regulation of protein export from nucleus	Txn1	IDA		Mouse	PMID:18555775
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Txn1	IGI	MGI:MGI:1930018	Mouse	PMID:18555775
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Txn1	IGI	MGI:MGI:1889549	Mouse	PMID:18555775
Biological Process	GO:0043388	positive regulation of DNA binding	TXN	IDA		Human	PMID:11118054
Biological Process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	TXN	IMP		Human	PMID:16408020
Biological Process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	TXN	IMP		Human	PMID:17606900
Biological Process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	TXN	IMP		Human	PMID:9108029
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	TXN	IGI	UniProtKB:Q99497	Human	PMID:22492997
Biological Process	GO:0014823	response to activity	Txn1	IEP		Rat	PMID:20601738|RGD:5133713
Biological Process	GO:0048678	response to axon injury	Txn1	IEP		Rat	PMID:19833109|RGD:5133729
Biological Process	GO:0071548	response to dexamethasone	Txn1	IEP		Rat	PMID:20393169|RGD:5133720
Biological Process	GO:0071731	response to nitric oxide	TXN	IMP		Human	PMID:16408020
Biological Process	GO:0071731	response to nitric oxide	TXN	IMP		Human	PMID:17606900
Biological Process	GO:0009314	response to radiation	TXN	IDA		Human	PMID:11118054
Biological Process	GO:0009314	response to radiation	TXN	IDA		Human	PMID:9108029
Biological Process	GO:0010269	response to selenium ion	Txn1	IEP		Rat	PMID:15792362|RGD:5133718
Biological Process	GO:0097068	response to thyroxine	Txn1	IEP		Rat	PMID:20729758|RGD:5133711
Biological Process	GO:0009410	response to xenobiotic stimulus	Txn1	IEP		Rat	PMID:18790005|RGD:5134340

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern