Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TXNIP
  • Mouse genes Txnip
  • Rat genes Txnip
  • Zfish genes txnipa,txnipb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Txnip

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004857	enzyme inhibitor activity	Txnip	IDA		Mouse	PMID:10843682
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:P10599	Human	PMID:10814541
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:O95171	Human	PMID:14632196
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:P10599	Human	PMID:17260951
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:O95905	Human	PMID:23880345
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:P52735	Human	PMID:26919541
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:P10599	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TXNIP	IPI	UniProtKB:P10599	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Txnip	IPI	PR:P10639	Mouse	PMID:18555775
Molecular Function	GO:0005515	protein binding	Txnip	IPI	PR:O89114	Mouse	PMID:18555775
Molecular Function	GO:0005515	protein binding	Txnip	IPI	UniProtKB:P10599	Mouse	PMID:10843682
Molecular Function	GO:0031625	ubiquitin protein ligase binding	TXNIP	IPI	UniProtKB:Q96J02	Human	PMID:20068034
Cellular Component	GO:0005737	cytoplasm	TXNIP	IDA		Human	PMID:14632196
Cellular Component	GO:0005737	cytoplasm	Txnip	IDA		Mouse	PMID:10843682
Cellular Component	GO:0005737	cytoplasm	Txnip	IDA		Rat	PMID:15834431|RGD:1642756
Cellular Component	GO:0005758	mitochondrial intermembrane space	Txnip	IDA		Rat	PMID:15834431|RGD:1642756
Cellular Component	GO:0005634	nucleus	Txnip	IDA		Rat	PMID:15834431|RGD:1642756
Biological Process	GO:0071228	cellular response to tumor cell	TXNIP	IDA		Human	PMID:18541147
Biological Process	GO:0030216	keratinocyte differentiation	TXNIP	IDA		Human	PMID:14632196
Biological Process	GO:0051782	negative regulation of cell division	TXNIP	IDA		Human	PMID:18541147
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Txnip	IGI	MGI:MGI:1930018	Mouse	PMID:18555775
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Txnip	IGI	MGI:MGI:98874	Mouse	PMID:18555775
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Txnip	IMP	MGI:MGI:3526865	Mouse	PMID:17143286
Biological Process	GO:0043065	positive regulation of apoptotic process	Txnip	IMP		Rat	PMID:16172122|RGD:1580789
Biological Process	GO:0006606	protein import into nucleus	Txnip	IMP		Mouse	PMID:18555775
Biological Process	GO:0042127	regulation of cell population proliferation	Txnip	IDA		Rat	PMID:12011048|RGD:727213
Biological Process	GO:0051592	response to calcium ion	Txnip	IEP		Rat	PMID:11579135|RGD:1642761
Biological Process	GO:0032355	response to estradiol	Txnip	IEP		Rat	PMID:15047938|RGD:1642759
Biological Process	GO:0009749	response to glucose	Txnip	IEP		Rat	PMID:12213820|RGD:631232
Biological Process	GO:0042542	response to hydrogen peroxide	Txnip	IEP		Rat	PMID:12011048|RGD:727213
Biological Process	GO:0009612	response to mechanical stimulus	Txnip	IEP		Rat	PMID:12011048|RGD:727213
Biological Process	GO:0006979	response to oxidative stress	Txnip	IDA		Mouse	PMID:10843682
Biological Process	GO:0032570	response to progesterone	Txnip	IEP		Rat	PMID:15047938|RGD:1642759
Biological Process	GO:0009410	response to xenobiotic stimulus	Txnip	IEP		Rat	PMID:16782054|RGD:1642755

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern