Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TXNRD1
  • Mouse genes Txnrd1
  • Rat genes Txnrd1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Txnrd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071949	FAD binding	TXNRD1	IDA		Human	PMID:8577704
Molecular Function	GO:0042802	identical protein binding	TXNRD1	IDA		Human	PMID:8577704
Molecular Function	GO:0042802	identical protein binding	Txnrd1	IPI	RGD:61959	Rat	PMID:14607844|RGD:5133693
Molecular Function	GO:0042802	identical protein binding	Txnrd1	IPI	RGD:61959	Rat	PMID:19146949|RGD:5134339
Molecular Function	GO:0045340	mercury ion binding	Txnrd1	IDA		Rat	PMID:20810785|RGD:5133710
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	Txnrd1	IDA		Rat	PMID:16481328|RGD:5133691
Molecular Function	GO:0050137	NADPH peroxidase activity	TXNRD1	IDA		Human	PMID:10849437
Molecular Function	GO:0050137	NADPH peroxidase activity	Txnrd1	IDA		Rat	PMID:10849437|RGD:634378
Molecular Function	GO:0005515	protein binding	TXNRD1	IPI	UniProtKB:Q03135	Human	PMID:19820694
Molecular Function	GO:0033797	selenate reductase activity	Txnrd1	IDA		Rat	PMID:20810785|RGD:5133710
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	TXNRD1	IDA		Human	PMID:8577704
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	Txnrd1	IDA		Mouse	PMID:11259642
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	Txnrd1	IDA		Rat	PMID:10849437|RGD:634378
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	Txnrd1	IDA		Rat	PMID:12435734|RGD:634375
Cellular Component	GO:0005737	cytoplasm	Txnrd1	IDA		Mouse	PMID:10721726
Cellular Component	GO:0005737	cytoplasm	Txnrd1	IDA		Rat	PMID:19833109|RGD:5133729
Cellular Component	GO:0005829	cytosol	Txnrd1	IDA		Mouse	PMID:11259642
Cellular Component	GO:0005829	cytosol	Txnrd1	IDA		Rat	PMID:9988709|RGD:61776
Cellular Component	GO:0070062	extracellular exosome	TXNRD1	HDA		Human	PMID:18570454
Cellular Component	GO:0001650	fibrillar center	TXNRD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Txnrd1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	Txnrd1	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005654	nucleoplasm	TXNRD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Txnrd1	IDA		Mouse	PMID:10721726
Biological Process	GO:0042537	benzene-containing compound metabolic process	Txnrd1	IDA		Rat	PMID:20345183|RGD:5133728
Biological Process	GO:0008283	cell population proliferation	Txnrd1	IMP	MGI:MGI:3574773	Mouse	PMID:15713651
Biological Process	GO:0071280	cellular response to copper ion	Txnrd1	IEP		Rat	PMID:19781568|RGD:5130971
Biological Process	GO:0071455	cellular response to hyperoxia	Txnrd1	IEP		Rat	PMID:21505996|RGD:5133704
Biological Process	GO:0007369	gastrulation	Txnrd1	IMP	MGI:MGI:3722092	Mouse	PMID:17697936
Biological Process	GO:0070276	halogen metabolic process	Txnrd1	IEP		Rat	PMID:21406454|RGD:5133705
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Txnrd1	IMP		Rat	PMID:10849437|RGD:634378
Biological Process	GO:0001707	mesoderm formation	Txnrd1	IMP	MGI:MGI:3722092	Mouse	PMID:17697936
Biological Process	GO:0070995	NADPH oxidation	Txnrd1	IDA		Rat	PMID:19054767|RGD:5133716
Biological Process	GO:0001890	placenta development	Txnrd1	IEP		Rat	PMID:20393169|RGD:5133720
Biological Process	GO:0043065	positive regulation of apoptotic process	Txnrd1	IMP		Rat	PMID:12574159|RGD:5134338
Biological Process	GO:0048678	response to axon injury	Txnrd1	IEP		Rat	PMID:19833109|RGD:5133729
Biological Process	GO:0055093	response to hyperoxia	Txnrd1	IEP		Rat	PMID:20493230|RGD:5133717
Biological Process	GO:0006979	response to oxidative stress	Txnrd1	IDA		Rat	PMID:12435734|RGD:634375
Biological Process	GO:0010269	response to selenium ion	Txnrd1	IEP		Rat	PMID:15792362|RGD:5133718
Biological Process	GO:0009410	response to xenobiotic stimulus	Txnrd1	IEP		Rat	PMID:19768707|RGD:5133730
Biological Process	GO:0016259	selenocysteine metabolic process	Txnrd1	IMP		Rat	PMID:10512699|RGD:634379

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern