Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TYK2
  • Mouse genes Tyk2
  • Rat genes Tyk2
  • Zfish genes tyk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tyk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005131	growth hormone receptor binding	TYK2	IPI	UniProtKB:P10912	Human	PMID:10502458
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TYK2	IDA		Human	PMID:7526154
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TYK2	IDA		Human	PMID:7657660
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TYK2	IDA		Human	PMID:8232552
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TYK2	IDA		Human	PMID:8605876
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q5VWX1	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P17181-1	Human	PMID:24704786
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P61978	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q13643	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q5VWX1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q9BUZ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:O60674	Human	PMID:26175413
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P61978	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:O75525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:O95994	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P61978-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q05BL1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q13643	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q5VWX1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q9NQX1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:Q9ULX6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P52630	Human	PMID:32953130
Molecular Function	GO:0005515	protein binding	TYK2	IPI	UniProtKB:P52630	Human	PMID:34521819
Molecular Function	GO:0004713	protein tyrosine kinase activity	TYK2	IDA		Human	PMID:10542297
Molecular Function	GO:0004713	protein tyrosine kinase activity	TYK2	EXP		Human	PMID:1386289
Molecular Function	GO:0004713	protein tyrosine kinase activity	TYK2	EXP		Human	PMID:8232552
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Tyk2	IPI	RGD:2070	Rat	PMID:9314843|RGD:6478796
Cellular Component	GO:0005737	cytoplasm	TYK2	IDA		Human	PMID:10502458
Cellular Component	GO:0070062	extracellular exosome	TYK2	HDA		Human	PMID:20458337
Cellular Component	GO:0005634	nucleus	TYK2	IDA		Human	PMID:10502458
Biological Process	GO:0008283	cell population proliferation	Tyk2	IGI	MGI:MGI:107670	Mouse	PMID:15781341
Biological Process	GO:0008283	cell population proliferation	Tyk2	IGI	MGI:MGI:2448469	Mouse	PMID:15781341
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	TYK2	IDA		Human	PMID:7528775
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	TYK2	IDA		Human	PMID:19088061
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	TYK2	IDA		Human	PMID:19088061
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	TYK2	IDA		Human	PMID:26479788
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	TYK2	IDA		Human	PMID:8605876
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	TYK2	IDA		Human	PMID:12023369
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	TYK2	IDA		Human	PMID:7638186
Biological Process	GO:0042102	positive regulation of T cell proliferation	TYK2	IDA		Human	PMID:11114383
Biological Process	GO:0042102	positive regulation of T cell proliferation	Tyk2	IDA		Mouse	MGI:MGI:1927676|PMID:11114383
Biological Process	GO:0032729	positive regulation of type II interferon production	TYK2	IDA		Human	PMID:12023369
Biological Process	GO:0032729	positive regulation of type II interferon production	TYK2	IDA		Human	PMID:19088061
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	TYK2	IDA		Human	PMID:7526154
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	TYK2	IDA		Human	PMID:7657660
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	TYK2	IDA		Human	PMID:8232552
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	TYK2	IDA		Human	PMID:8605876
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	TYK2	IDA		Human	PMID:8232552
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	TYK2	IDA		Human	PMID:8232552

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern