Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tyms

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TYMS
- Mouse genes Tyms
- Rat genes Tyms
- Zfish genes tyms
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tyms

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	tyms	IDA		Zfish	PMID:16751599
Molecular Function	GO:0005542	folic acid binding	Tyms	IDA		Rat	PMID:7537805\|RGD:2317419
Molecular Function	GO:1901363	heterocyclic compound binding	Tyms	IPI	CHEBI:41742	Rat	PMID:9894005\|RGD:1545055
Molecular Function	GO:0003729	mRNA binding	Tyms	IPI	CHEBI:33699	Rat	PMID:9891091\|RGD:5133445
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	TYMS	IDA		Human	PMID:1924359
Molecular Function	GO:0042803	protein homodimerization activity	Tyms	IDA		Rat	PMID:9894005\|RGD:1545055
Molecular Function	GO:1990825	sequence-specific mRNA binding	TYMS	IDA		Human	PMID:1924359
Molecular Function	GO:0004799	thymidylate synthase activity	TYMS	IDA		Human	PMID:11278511
Molecular Function	GO:0004799	thymidylate synthase activity	TYMS	IDA		Human	PMID:15093541
Molecular Function	GO:0004799	thymidylate synthase activity	TYMS	IDA		Human	PMID:8845352
Molecular Function	GO:0004799	thymidylate synthase activity	Tyms	IDA		Mouse	PMID:22057276
Molecular Function	GO:0004799	thymidylate synthase activity	Tyms	IDA		Rat	PMID:9894005\|RGD:1545055
Molecular Function	GO:0004799	thymidylate synthase activity	tyms	IDA		Zfish	PMID:16751599
Cellular Component	GO:0005737	cytoplasm	TYMS	IDA		Human	PMID:21876188
Cellular Component	GO:0005743	mitochondrial inner membrane	TYMS	IDA		Human	PMID:21876188
Cellular Component	GO:0005759	mitochondrial matrix	TYMS	IDA		Human	PMID:21876188
Cellular Component	GO:0005739	mitochondrion	TYMS	IDA		Human	PMID:21876188
Cellular Component	GO:0005739	mitochondrion	Tyms	IDA		Rat	PMID:9148948\|RGD:5133448
Cellular Component	GO:0005730	nucleolus	Tyms	IDA		Rat	PMID:9148948\|RGD:5133448
Cellular Component	GO:0005634	nucleus	TYMS	IDA		Human	PMID:21876188
Cellular Component	GO:0005634	nucleus	Tyms	IDA		Mouse	PMID:22057276
Cellular Component	GO:0005634	nucleus	Tyms	IDA		Mouse	PMID:19513116
Biological Process	GO:0007568	aging	Tyms	IEP		Rat	PMID:3471366\|RGD:2317423
Biological Process	GO:0051216	cartilage development	Tyms	IEP		Rat	PMID:3471366\|RGD:2317423
Biological Process	GO:0007623	circadian rhythm	Tyms	IEP		Rat	PMID:19628084\|RGD:5133425
Biological Process	GO:0048589	developmental growth	Tyms	IEP		Rat	PMID:7471094\|RGD:2317424
Biological Process	GO:0006231	dTMP biosynthetic process	TYMS	IDA		Human	PMID:11278511
Biological Process	GO:0006231	dTMP biosynthetic process	TYMS	IDA		Human	PMID:15093541
Biological Process	GO:0006231	dTMP biosynthetic process	TYMS	IDA		Human	PMID:8845352
Biological Process	GO:0006231	dTMP biosynthetic process	Tyms	IDA		Mouse	PMID:22057276
Biological Process	GO:0006231	dTMP biosynthetic process	Tyms	IDA		Rat	PMID:9894005\|RGD:1545055
Biological Process	GO:0006231	dTMP biosynthetic process	tyms	IDA		Zfish	PMID:16751599
Biological Process	GO:0001654	eye development	tyms	IMP		Zfish	PMID:25294789
Biological Process	GO:0060574	intestinal epithelial cell maturation	Tyms	IEP		Rat	PMID:1260861\|RGD:2317427
Biological Process	GO:0097421	liver regeneration	Tyms	IEP		Rat	PMID:2707640\|RGD:2317422
Biological Process	GO:0017148	negative regulation of translation	TYMS	IDA		Human	PMID:1924359
Biological Process	GO:0006206	pyrimidine nucleobase metabolic process	Tyms	IEP		Rat	PMID:9524100\|RGD:5133447
Biological Process	GO:0006417	regulation of translation	Tyms	IDA		Rat	PMID:26315778\|RGD:11075099
Biological Process	GO:0034097	response to cytokine	Tyms	IEP		Rat	PMID:10767379\|RGD:5133432
Biological Process	GO:0034097	response to cytokine	Tyms	IEP		Rat	PMID:9524100\|RGD:5133447
Biological Process	GO:0045471	response to ethanol	Tyms	IEP		Rat	PMID:9305788\|RGD:5133427
Biological Process	GO:0051593	response to folic acid	Tyms	IEP		Rat	PMID:9528665\|RGD:5133428
Biological Process	GO:0051384	response to glucocorticoid	Tyms	IEP		Rat	PMID:2707640\|RGD:2317422
Biological Process	GO:0014070	response to organic cyclic compound	Tyms	IEP		Rat	PMID:9683817\|RGD:5133446
Biological Process	GO:0046683	response to organophosphorus	TYMS	IEP		Human	PMID:16079077
Biological Process	GO:0032570	response to progesterone	Tyms	IEP		Rat	PMID:9635926\|RGD:2315839
Biological Process	GO:0009636	response to toxic substance	Tyms	IEP		Rat	PMID:8781506\|RGD:5133429
Biological Process	GO:0033189	response to vitamin A	Tyms	IEP		Rat	PMID:10395942\|RGD:5133444
Biological Process	GO:0009410	response to xenobiotic stimulus	Tyms	IEP		Rat	PMID:7686361\|RGD:2317421
Biological Process	GO:0060041	retina development in camera-type eye	tyms	IMP	ZFIN:ZDB-GENO-040827-8	Zfish	PMID:15716491
Biological Process	GO:0035999	tetrahydrofolate interconversion	TYMS	IDA		Human	PMID:15093541
Biological Process	GO:0035999	tetrahydrofolate interconversion	Tyms	IDA		Mouse	PMID:22057276
Biological Process	GO:0046653	tetrahydrofolate metabolic process	Tyms	IEP		Rat	PMID:7503782\|RGD:5133451
Biological Process	GO:0019860	uracil metabolic process	Tyms	IEP		Rat	PMID:2043679\|RGD:5133426

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.