Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TYR
  • Mouse genes Tyr
  • Rat genes Tyr
  • Zfish genes tyr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tyr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004097	catechol oxidase activity	tyr	IMP	ZFIN:ZDB-GENO-980202-1401	Zfish	PMID:24173565
Molecular Function	GO:0005507	copper ion binding	TYR	IMP		Human	PMID:11092760
Molecular Function	GO:0042802	identical protein binding	TYR	IDA		Human	PMID:28842328
Molecular Function	GO:0042802	identical protein binding	Tyr	IPI	PR:P11344	Mouse	PMID:9918801
Molecular Function	GO:0005515	protein binding	TYR	IPI	UniProtKB:O43747	Human	PMID:16162817
Molecular Function	GO:0005515	protein binding	TYR	IPI	UniProtKB:Q92572	Human	PMID:16162817
Molecular Function	GO:0005515	protein binding	TYR	IPI	UniProtKB:P51810	Human	PMID:27720922
Molecular Function	GO:0005515	protein binding	TYR	IPI	UniProtKB:P40126	Human	PMID:28842328
Molecular Function	GO:0005515	protein binding	Tyr	IPI	UniProtKB:P07147	Mouse	MGI:MGI:3771504|PMID:18042623
Molecular Function	GO:0005515	protein binding	Tyr	IPI	UniProtKB:P07147	Mouse	MGI:MGI:3687692|PMID:9918801
Molecular Function	GO:0042803	protein homodimerization activity	Tyr	IDA		Mouse	MGI:MGI:3687692|PMID:9918801
Molecular Function	GO:0004503	tyrosinase activity	TYR	IDA		Human	PMID:11092760
Cellular Component	GO:0005737	cytoplasm	TYR	IDA		Human	PMID:11092760
Cellular Component	GO:0005829	cytosol	Tyr	IDA		Rat	PMID:1519262|RGD:8694333
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TYR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042470	melanosome	Tyr	IDA		Mouse	MGI:MGI:5755324|PMID:26620560
Cellular Component	GO:0042470	melanosome	Tyr	IDA		Mouse	MGI:MGI:3687692|PMID:9918801
Cellular Component	GO:0042470	melanosome	Tyr	IDA		Mouse	PMID:22275436
Cellular Component	GO:0005634	nucleus	Tyr	IDA		Rat	PMID:1519262|RGD:8694333
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TYR	IDA		Human	PMID:11092760
Biological Process	GO:0008283	cell population proliferation	Tyr	IMP	MGI:MGI:1855976	Mouse	PMID:9548375
Biological Process	GO:0048066	developmental pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-88	Zfish	PMID:9007256
Biological Process	GO:0048066	developmental pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-86	Zfish	PMID:9007256
Biological Process	GO:0048066	developmental pigmentation	tyr	IMP	ZFIN:ZDB-GENO-980202-1401	Zfish	PMID:9007256
Biological Process	GO:0048066	developmental pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-85	Zfish	PMID:9007256
Biological Process	GO:0048066	developmental pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-87	Zfish	PMID:9007256
Biological Process	GO:0048066	developmental pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-89	Zfish	PMID:9007256
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	tyr	IMP	ZFIN:ZDB-GENO-060825-4	Zfish	PMID:15516923
Biological Process	GO:0050935	iridophore differentiation	tyr	IMP	ZFIN:ZDB-GENO-101027-11	Zfish	PMID:24330346
Biological Process	GO:0042438	melanin biosynthetic process	TYR	IDA		Human	PMID:8126111
Biological Process	GO:0042438	melanin biosynthetic process	Tyr	IMP	MGI:MGI:1855978	Mouse	PMID:7665913
Biological Process	GO:0042438	melanin biosynthetic process	Tyr	IMP	MGI:MGI:1855976	Mouse	PMID:9548375
Biological Process	GO:0030318	melanocyte differentiation	tyr	IMP	ZFIN:ZDB-MRPHLNO-181114-2	Zfish	PMID:30061422
Biological Process	GO:0032438	melanosome organization	tyr	IMP	ZFIN:ZDB-MRPHLNO-060927-4	Zfish	PMID:25690007
Biological Process	GO:0043473	pigmentation	Tyr	IMP	MGI:MGI:1855978	Mouse	PMID:17247639
Biological Process	GO:0043473	pigmentation	Tyr	IMP	MGI:MGI:1855976	Mouse	PMID:13880466
Biological Process	GO:0043473	pigmentation	Tyr	IMP	MGI:MGI:1855976	Mouse	PMID:9548375
Biological Process	GO:0043473	pigmentation	Tyr	IMP		Rat	PMID:15760344|RGD:1599687
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-221206-12	Zfish	PMID:33602923
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-85	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-88	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-86	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-170201-10	Zfish	PMID:27802373
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-89	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-120316-87	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	tyr	IMP	ZFIN:ZDB-GENO-980202-1401	Zfish	PMID:9007256
Biological Process	GO:0009637	response to blue light	TYR	IDA		Human	PMID:28842328
Biological Process	GO:0051591	response to cAMP	Tyr	IEP		Rat	PMID:6175546|RGD:8694330
Biological Process	GO:0009411	response to UV	Tyr	IEP		Rat	PMID:6175546|RGD:8694330
Biological Process	GO:0033280	response to vitamin D	Tyr	IEP		Rat	PMID:6175546|RGD:8694330
Biological Process	GO:0048538	thymus development	Tyr	IMP	MGI:MGI:1856308	Mouse	PMID:10890980

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern