Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TYRO3
  • Mouse genes Tyro3
  • Rat genes Tyro3
  • Zfish genes tyro3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tyro3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	TYRO3	IPI	UniProtKB:O00459	Human	PMID:10627473
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Tyro3	IPI	RGD:68478	Rat	PMID:10627473|RGD:1580534
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P26371	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:Q9BYR5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:Q9Y5K2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P26371	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:B2RUY7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P62993	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:Q9BYQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P08238	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:P62993	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	TYRO3	IPI	UniProtKB:Q14393	Human	PMID:7634325
Molecular Function	GO:0005515	protein binding	Tyro3	IPI	PR:Q00993	Mouse	PMID:18787040
Molecular Function	GO:0004713	protein tyrosine kinase activity	TYRO3	IDA		Human	PMID:7537495
Molecular Function	GO:0001618	virus receptor activity	TYRO3	IDA		Human	PMID:22156524
Cellular Component	GO:0009986	cell surface	TYRO3	IDA		Human	PMID:7511603
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Tyro3	IDA		Rat	PMID:9175267|RGD:8554066
Cellular Component	GO:0005635	nuclear envelope	Tyro3	IDA		Rat	PMID:9175267|RGD:8554066
Cellular Component	GO:0005634	nucleus	Tyro3	IDA		Rat	PMID:9175267|RGD:8554066
Biological Process	GO:0043277	apoptotic cell clearance	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18159085
Biological Process	GO:0043277	apoptotic cell clearance	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:17442946
Biological Process	GO:0043277	apoptotic cell clearance	Tyro3	IGI	MGI:MGI:96965	Mouse	PMID:18159085
Biological Process	GO:0051649	establishment of localization in cell	Tyro3	IMP	MGI:MGI:2387762	Mouse	PMID:15650770
Biological Process	GO:0021885	forebrain cell migration	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18787040
Biological Process	GO:0003094	glomerular filtration	tyro3	IMP	ZFIN:ZDB-MRPHLNO-200225-1	Zfish	PMID:30429374
Biological Process	GO:0046649	lymphocyte activation	Tyro3	IGI	MGI:MGI:96965	Mouse	PMID:11452127
Biological Process	GO:0046649	lymphocyte activation	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:11452127
Biological Process	GO:0001779	natural killer cell differentiation	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:16751775
Biological Process	GO:0001779	natural killer cell differentiation	Tyro3	IGI	MGI:MGI:96965	Mouse	PMID:16751775
Biological Process	GO:0050728	negative regulation of inflammatory response	Tyro3	IGI	UniProtKB:Q00993|UniProtKB:Q60805	Mouse	MGI:MGI:3773763|PMID:18083102
Biological Process	GO:0045824	negative regulation of innate immune response	Tyro3	IGI	UniProtKB:Q00993|UniProtKB:Q60805	Mouse	MGI:MGI:3773763|PMID:18083102
Biological Process	GO:0051250	negative regulation of lymphocyte activation	Tyro3	IGI	MGI:MGI:96965	Mouse	PMID:11452127
Biological Process	GO:0051250	negative regulation of lymphocyte activation	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:11452127
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18787040
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Tyro3	IGI	UniProtKB:Q00993|UniProtKB:Q60805	Mouse	MGI:MGI:3773763|PMID:18083102
Biological Process	GO:0051402	neuron apoptotic process	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18787040
Biological Process	GO:0070050	neuron cellular homeostasis	Tyro3	IMP		Mouse	MGI:MGI:5315335|PMID:21084607
Biological Process	GO:0001764	neuron migration	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18787040
Biological Process	GO:0007218	neuropeptide signaling pathway	Tyro3	IMP	MGI:MGI:1856657	Mouse	PMID:9331176
Biological Process	GO:0042698	ovulation cycle	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18787040
Biological Process	GO:0030168	platelet activation	Tyro3	IMP	MGI:MGI:2387762	Mouse	PMID:15650770
Biological Process	GO:0070527	platelet aggregation	Tyro3	IMP		Mouse	MGI:MGI:5306558|PMID:20546121
Biological Process	GO:0072015	podocyte development	tyro3	IMP	ZFIN:ZDB-MRPHLNO-200225-1	Zfish	PMID:30429374
Biological Process	GO:1903902	positive regulation of viral life cycle	TYRO3	IMP		Human	PMID:22673088
Biological Process	GO:0046777	protein autophosphorylation	TYRO3	IDA		Human	PMID:7511603
Biological Process	GO:0046777	protein autophosphorylation	TYRO3	IDA		Human	PMID:7537495
Biological Process	GO:0043491	protein kinase B signaling	Tyro3	IMP		Mouse	MGI:MGI:5315335|PMID:21084607
Biological Process	GO:0043491	protein kinase B signaling	Tyro3	IGI	MGI:MGI:95660	Mouse	PMID:15650770
Biological Process	GO:0006468	protein phosphorylation	Tyro3	IDA		Rat	PMID:10627473|RGD:1580534
Biological Process	GO:0032940	secretion by cell	Tyro3	IMP	MGI:MGI:2387762	Mouse	PMID:15650770
Biological Process	GO:0007283	spermatogenesis	Tyro3	IGI	MGI:MGI:96965	Mouse	PMID:10227296
Biological Process	GO:0007283	spermatogenesis	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:10227296
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Tyro3	IMP	MGI:MGI:2387762	Mouse	PMID:15650770
Biological Process	GO:0060068	vagina development	Tyro3	IGI	MGI:MGI:1347244	Mouse	PMID:18393392
Biological Process	GO:0060068	vagina development	Tyro3	IGI	MGI:MGI:96965	Mouse	PMID:18393392

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern