Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tyrobp

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TYROBP
- Mouse genes Tyrobp
- Rat genes Tyrobp
- Zfish genes tyrobp
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tyrobp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TYROBP	IPI	UniProtKB:O43914	Human	PMID:20890284
Molecular Function	GO:0019209	kinase activator activity	TYROBP	IDA		Human	PMID:10799849
Molecular Function	GO:0019209	kinase activator activity	TYROBP	IDA		Human	PMID:23459077
Molecular Function	GO:0060090	molecular adaptor activity	TYROBP	IDA		Human	PMID:10799849
Molecular Function	GO:0060090	molecular adaptor activity	TYROBP	IDA		Human	PMID:23459077
Molecular Function	GO:0060090	molecular adaptor activity	TYROBP	IDA		Human	PMID:26358190
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:O95944	Human	PMID:10049942
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:O00241	Human	PMID:10940905
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:Q9NZC2	Human	PMID:11602640
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:O95944	Human	PMID:14707061
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:Q14953	Human	PMID:18624290
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:A0A0K2S4Q6	Human	PMID:26221034
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:A6NMB1	Human	PMID:28100677
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:Q9NZC2	Human	PMID:28490631
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:Q8N2M4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:Q969S0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:P26717	Human	PMID:9655483
Molecular Function	GO:0005515	protein binding	TYROBP	IPI	UniProtKB:P43631	Human	PMID:9655483
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	UniProtKB:Q9JKE1	Mouse	MGI:MGI:2157214\|PMID:11754004
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	UniProtKB:Q60651\|UniProtKB:Q60682	Mouse	MGI:MGI:1276991\|PMID:9647200
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	UniProtKB:Q9QUJ0\|UniProtKB:Q9R007	Mouse	MGI:MGI:3839503\|PMID:19251634
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	UniProtKB:P48025	Mouse	MGI:MGI:3693026\|PMID:17086186
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	PR:O54709-2	Mouse	PMID:12426565
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	PR:Q3LRV9	Mouse	PMID:19155473
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	PR:Q7TSN2	Mouse	PMID:12893283
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	PR:Q8BP97	Mouse	PMID:23610400
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	MGI:MGI:3646642	Mouse	PMID:22451653
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	PR:O54709-1	Mouse	PMID:12426565
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	PR:Q7TSN2	Mouse	PMID:12874256
Molecular Function	GO:0005515	protein binding	Tyrobp	IPI	RGD:628683	Rat	PMID:12077224\|RGD:633264
Molecular Function	GO:0005515	protein binding	tyrobp	IPI	UniProtKB:Q5YCY7	Zfish	PMID:17891481
Molecular Function	GO:0042803	protein homodimerization activity	TYROBP	IDA		Human	PMID:9655483
Molecular Function	GO:0005102	signaling receptor binding	TYROBP	IPI	UniProtKB:Q9NP99	Human	PMID:11602640
Molecular Function	GO:0005102	signaling receptor binding	TYROBP	IPI	UniProtKB:Q9NZC2	Human	PMID:11602640
Molecular Function	GO:0005102	signaling receptor binding	TYROBP	IPI	UniProtKB:O54709-2	Human	PMID:15294961
Molecular Function	GO:0005102	signaling receptor binding	Tyrobp	IPI	UniProtKB:Q99NH8	Mouse	MGI:MGI:6150565\|PMID:29518356
Cellular Component	GO:0009986	cell surface	TYROBP	IDA		Human	PMID:10799849
Cellular Component	GO:0009986	cell surface	TYROBP	IDA		Human	PMID:23459077
Cellular Component	GO:0009986	cell surface	TYROBP	IDA		Human	PMID:15294961
Cellular Component	GO:0009986	cell surface	Tyrobp	IDA		Mouse	MGI:MGI:1276991\|PMID:9647200
Cellular Component	GO:0005886	plasma membrane	TYROBP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TYROBP	IDA		Human	PMID:9655483
Biological Process	GO:0030036	actin cytoskeleton organization	Tyrobp	IMP		Mouse	MGI:MGI:3808621\|PMID:18691974
Biological Process	GO:0043277	apoptotic cell clearance	Tyrobp	IMP		Mouse	MGI:MGI:3531054\|PMID:15728241
Biological Process	GO:0097190	apoptotic signaling pathway	Tyrobp	IDA		Mouse	MGI:MGI:3812233\|PMID:18685038
Biological Process	GO:0030900	forebrain development	Tyrobp	IDA		Mouse	MGI:MGI:3812233\|PMID:18685038
Biological Process	GO:0007229	integrin-mediated signaling pathway	Tyrobp	IMP		Mouse	MGI:MGI:3693026\|PMID:17086186
Biological Process	GO:0002281	macrophage activation involved in immune response	Tyrobp	IMP		Mouse	MGI:MGI:3693026\|PMID:17086186
Biological Process	GO:0002282	microglial cell activation involved in immune response	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0002274	myeloid leukocyte activation	TYROBP	IDA		Human	PMID:10604985
Biological Process	GO:0030889	negative regulation of B cell proliferation	TYROBP	IMP		Human	PMID:21727189
Biological Process	GO:0030889	negative regulation of B cell proliferation	Tyrobp	IMP		Mouse	MGI:MGI:5295549\|PMID:21727189
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Tyrobp	IMP		Mouse	MGI:MGI:3531596\|PMID:15601948
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0032480	negative regulation of type I interferon production	TYROBP	IDA		Human	PMID:26358190
Biological Process	GO:0002283	neutrophil activation involved in immune response	Tyrobp	IMP		Mouse	MGI:MGI:3693026\|PMID:17086186
Biological Process	GO:0030316	osteoclast differentiation	TYROBP	IMP		Human	PMID:21841309
Biological Process	GO:0030316	osteoclast differentiation	Tyrobp	IGI	MGI:MGI:2179720	Mouse	PMID:21841309
Biological Process	GO:0030316	osteoclast differentiation	Tyrobp	IDA		Mouse	PMID:21841309
Biological Process	GO:0030316	osteoclast differentiation	Tyrobp	IMP	MGI:MGI:2450834	Mouse	PMID:21841309
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	tyrobp	IPI	UniProtKB:Q5YCY7	Zfish	PMID:17891481
Biological Process	GO:0010628	positive regulation of gene expression	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0110090	positive regulation of hippocampal neuron apoptotic process	Tyrobp	IDA		Mouse	MGI:MGI:3812233\|PMID:18685038
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0034241	positive regulation of macrophage fusion	TYROBP	IMP		Human	PMID:18957693
Biological Process	GO:0034241	positive regulation of macrophage fusion	Tyrobp	IMP		Mouse	MGI:MGI:6142486\|PMID:18957693
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	Tyrobp	IMP		Mouse	MGI:MGI:3812233\|PMID:18685038
Biological Process	GO:0032816	positive regulation of natural killer cell activation	Tyrobp	IDA		Mouse	MGI:MGI:1276991\|PMID:9647200
Biological Process	GO:1901216	positive regulation of neuron death	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:2001206	positive regulation of osteoclast development	Tyrobp	IMP		Mouse	MGI:MGI:3653295\|PMID:14969392
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	TYROBP	IMP		Human	PMID:23715743
Biological Process	GO:1902685	positive regulation of receptor localization to synapse	Tyrobp	IMP		Mouse	MGI:MGI:3531596\|PMID:15601948
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Tyrobp	IDA		Mouse	MGI:MGI:3812233\|PMID:18685038
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0050821	protein stabilization	TYROBP	IMP		Human	PMID:23715743
Biological Process	GO:0050821	protein stabilization	TYROBP	IDA		Human	PMID:25957402
Biological Process	GO:2001204	regulation of osteoclast development	Tyrobp	IGI	MGI:MGI:3646642	Mouse	PMID:22451653
Biological Process	GO:0048678	response to axon injury	Tyrobp	IMP		Mouse	MGI:MGI:5638298\|PMID:25690660
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TYROBP	IDA		Human	PMID:9655483
Biological Process	GO:0002222	stimulatory killer cell immunoglobulin-like receptor signaling pathway	TYROBP	IDA		Human	PMID:9655483

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.