Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TYRP1
  • Mouse genes Tyrp1
  • Rat genes Tyrp1
  • Zfish genes tyrp1a,tyrp1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tyrp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Tyrp1	IPI	PR:P07147	Mouse	PMID:9918801
Molecular Function	GO:0005515	protein binding	TYRP1	IPI	UniProtKB:O14908	Human	PMID:11441007
Molecular Function	GO:0005515	protein binding	TYRP1	IPI	UniProtKB:Q9H1H9	Human	PMID:19841138
Molecular Function	GO:0005515	protein binding	TYRP1	IPI	UniProtKB:Q9UKG1	Human	PMID:21291857
Molecular Function	GO:0005515	protein binding	TYRP1	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tyrp1	IPI	UniProtKB:P58355	Mouse	MGI:MGI:7338895|PMID:35469906
Molecular Function	GO:0005515	protein binding	Tyrp1	IPI	UniProtKB:P11344	Mouse	MGI:MGI:3771504|PMID:18042623
Molecular Function	GO:0005515	protein binding	Tyrp1	IPI	UniProtKB:Q64430	Mouse	MGI:MGI:3807110|PMID:18650808
Molecular Function	GO:0005515	protein binding	Tyrp1	IPI	PR:P11344	Mouse	PMID:9918801
Molecular Function	GO:0042803	protein homodimerization activity	Tyrp1	IDA		Mouse	MGI:MGI:3687692|PMID:9918801
Molecular Function	GO:0004503	tyrosinase activity	TYRP1	IDA		Human	PMID:21291857
Cellular Component	GO:0030669	clathrin-coated endocytic vesicle membrane	TYRP1	IDA		Human	PMID:19841138
Cellular Component	GO:0005737	cytoplasm	TYRP1	IDA		Human	PMID:21291857
Cellular Component	GO:0010008	endosome membrane	TYRP1	IDA		Human	PMID:19841138
Cellular Component	GO:0097708	intracellular vesicle	TYRP1	IDA		Human	PMID:21291857
Cellular Component	GO:0042470	melanosome	Tyrp1	IDA		Mouse	MGI:MGI:5755324|PMID:26620560
Cellular Component	GO:0042470	melanosome	Tyrp1	IDA		Mouse	MGI:MGI:3687692|PMID:9918801
Cellular Component	GO:0042470	melanosome	Tyrp1	IDA		Mouse	PMID:22275436
Cellular Component	GO:0042470	melanosome	Tyrp1	IDA		Mouse	PMID:27390154
Cellular Component	GO:0033162	melanosome membrane	Tyrp1	IDA		Mouse	MGI:MGI:3720411|PMID:17182842
Biological Process	GO:0043438	acetoacetic acid metabolic process	Tyrp1	IMP	MGI:MGI:1855960	Mouse	PMID:7665913
Biological Process	GO:0006582	melanin metabolic process	Tyrp1	IMP	MGI:MGI:1855960	Mouse	PMID:9548375
Biological Process	GO:0030318	melanocyte differentiation	Tyrp1	IMP	MGI:MGI:1855962	Mouse	PMID:2379821
Biological Process	GO:0030318	melanocyte differentiation	tyrp1b	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:27141993
Biological Process	GO:0030318	melanocyte differentiation	tyrp1a	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:27141993
Biological Process	GO:0032438	melanosome organization	Tyrp1	IMP	MGI:MGI:1855960	Mouse	PMID:9548375
Biological Process	GO:0032438	melanosome organization	tyrp1b	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-1	Zfish	PMID:19659755
Biological Process	GO:0032438	melanosome organization	tyrp1b	IGI	ZFIN:ZDB-MRPHLNO-091218-3,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:19659755
Biological Process	GO:0032438	melanosome organization	tyrp1a	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-1	Zfish	PMID:19659755
Biological Process	GO:0032438	melanosome organization	tyrp1a	IMP	ZFIN:ZDB-GENO-150429-5	Zfish	PMID:24891189
Biological Process	GO:0032438	melanosome organization	tyrp1a	IGI	ZFIN:ZDB-MRPHLNO-091218-3,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:19659755
Biological Process	GO:0043473	pigmentation	Tyrp1	IMP	MGI:MGI:1855962	Mouse	PMID:2379821
Biological Process	GO:0043473	pigmentation	Tyrp1	IMP	MGI:MGI:1855960	Mouse	PMID:17247639
Biological Process	GO:0043473	pigmentation	Tyrp1	IMP	MGI:MGI:1855960	Mouse	PMID:13880466
Biological Process	GO:0043473	pigmentation	tyrp1b	IGI	ZFIN:ZDB-MRPHLNO-091218-3,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:19659755
Biological Process	GO:0043473	pigmentation	tyrp1b	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-1	Zfish	PMID:19659755
Biological Process	GO:0043473	pigmentation	tyrp1a	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-1	Zfish	PMID:19659755
Biological Process	GO:0043473	pigmentation	tyrp1a	IGI	ZFIN:ZDB-MRPHLNO-091218-3,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:19659755
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	TYRP1	IMP		Human	PMID:21996312
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	Tyrp1	IGI	UniProtKB:Q03288|UniProtKB:Q60696	Mouse	MGI:MGI:5294257|PMID:21949658
Biological Process	GO:0097066	response to thyroid hormone	tyrp1b	IDA		Zfish	PMID:27832141
Biological Process	GO:0003406	retinal pigment epithelium development	tyrp1b	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:27141993
Biological Process	GO:0003406	retinal pigment epithelium development	tyrp1a	IGI	ZFIN:ZDB-MRPHLNO-091217-5,ZFIN:ZDB-MRPHLNO-091218-5	Zfish	PMID:27141993

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern