Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UBE2N
  • Mouse genes Ube2n
  • Rat genes Ube2n
  • Zfish genes ube2na,ube2nb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ube2n

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q15819	Human	PMID:11473255
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:O95999	Human	PMID:14695475
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9Y3C5	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13404	Human	PMID:16129784
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q15819	Human	PMID:16129784
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13404	Human	PMID:16307917
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9UNE7	Human	PMID:16307917
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9WUD1	Human	PMID:16307917
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q149N8-1	Human	PMID:17108083
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q14527	Human	PMID:18316726
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q14527	Human	PMID:18719106
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8IYW5	Human	PMID:19203578
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:O95376	Human	PMID:19340006
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9Y4K3	Human	PMID:19465916
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:P98170	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13049	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13404	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q15819	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q6PCD5	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q6UWE0	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8ND25	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9BYM8	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9Y3C5	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9Y4K3	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:O43567	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13049	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13489	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q6UWE0	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8N6D2	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8ND25	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9Y3C5	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q96FW1	Human	PMID:20725033
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9BSD3	Human	PMID:21659603
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:O76064	Human	PMID:22266820
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13404-2	Human	PMID:22367539
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q96FW1-1	Human	PMID:22367539
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9XVR6	Human	PMID:22367539
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8VSD5	Human	PMID:22407319
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9UNE7	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:O43567	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13404	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13489	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q62925	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q6PCD5	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q6UWE0	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8N6D2	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9BYM8	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9UNE7	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q13049	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q15819	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q8ND25	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	UBE2N	IPI	UniProtKB:Q9Y4K3	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	Ube2n	IPI	UniProtKB:Q921N8	Mouse	MGI:MGI:6148454|PMID:22424771
Molecular Function	GO:0005515	protein binding	Ube2n	IPI	PR:Q9CZY3	Mouse	PMID:23776175
Molecular Function	GO:0005515	protein binding	Ube2n	IPI	PR:Q9CZY3	Mouse	PMID:12039045
Molecular Function	GO:0005515	protein binding	Ube2n	IPI	PR:Q9D2M8	Mouse	PMID:12039045
Molecular Function	GO:0005515	protein binding	Ube2n	IPI	UniProtKB:Q9Y4K3	Mouse	PMID:23776175
Molecular Function	GO:0003723	RNA binding	UBE2N	HDA		Human	PMID:22681889
Molecular Function	GO:0043130	ubiquitin binding	UBE2N	IDA		Human	PMID:16122702
Molecular Function	GO:0061631	ubiquitin conjugating enzyme activity	Ube2n	IDA		Mouse	MGI:MGI:5896692|PMID:28039360
Molecular Function	GO:0061631	ubiquitin conjugating enzyme activity	Ube2n	IDA		Mouse	MGI:MGI:6148454|PMID:22424771
Molecular Function	GO:0061631	ubiquitin conjugating enzyme activity	Ube2n	IDA		Mouse	PMID:22797923
Molecular Function	GO:0061631	ubiquitin conjugating enzyme activity	Ube2n	IDA		Mouse	PMID:12039045
Molecular Function	GO:0031625	ubiquitin protein ligase binding	UBE2N	IPI	UniProtKB:Q9H992	Human	PMID:18410486
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	UBE2N	IDA		Human	PMID:20061386
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Ube2n	IMP		Rat	PMID:11882492|RGD:724779
Cellular Component	GO:0005737	cytoplasm	UBE2N	IDA		Human	PMID:19340006
Cellular Component	GO:0005829	cytosol	UBE2N	IDA		Human	PMID:16129784
Cellular Component	GO:0070062	extracellular exosome	UBE2N	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	UBE2N	HDA		Human	PMID:23533145
Cellular Component	GO:0001650	fibrillar center	UBE2N	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	UBE2N	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	UBE2N	IDA		Human	PMID:16129784
Cellular Component	GO:0005634	nucleus	UBE2N	IDA		Human	PMID:19340006
Cellular Component	GO:0005634	nucleus	Ube2n	IDA		Mouse	PMID:15383616
Cellular Component	GO:0032991	protein-containing complex	UBE2N	IDA		Human	PMID:22797923
Cellular Component	GO:0031372	UBC13-MMS2 complex	UBE2N	IPI		Human	PMID:11473255
Cellular Component	GO:0031372	UBC13-MMS2 complex	UBE2N	IDA		Human	PMID:16129784
Cellular Component	GO:0035370	UBC13-UEV1A complex	UBE2N	IPI		Human	PMID:11057907
Cellular Component	GO:0035370	UBC13-UEV1A complex	UBE2N	IDA		Human	PMID:16307917
Cellular Component	GO:0000151	ubiquitin ligase complex	UBE2N	IDA		Human	PMID:16307917
Biological Process	GO:0006974	DNA damage response	ube2nb	IDA		Zfish	PMID:20556485
Biological Process	GO:0006974	DNA damage response	ube2na	IDA		Zfish	PMID:20556485
Biological Process	GO:0000729	DNA double-strand break processing	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0000724	double-strand break repair via homologous recombination	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0016574	histone ubiquitination	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0045739	positive regulation of DNA repair	UBE2N	IMP		Human	PMID:16129784
Biological Process	GO:2000781	positive regulation of double-strand break repair	UBE2N	IDA		Human	PMID:16129784
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	UBE2N	IMP		Human	PMID:16129784
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	UBE2N	IDA		Human	PMID:11057907
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	UBE2N	IMP		Human	PMID:14695475
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	UBE2N	IMP		Human	PMID:16129784
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	UBE2N	IDA		Human	PMID:10089880
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	UBE2N	IDA		Human	PMID:11057907
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0006301	postreplication repair	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0070534	protein K63-linked ubiquitination	UBE2N	IDA		Human	PMID:16307917
Biological Process	GO:0070534	protein K63-linked ubiquitination	UBE2N	IDA		Human	PMID:20061386
Biological Process	GO:0070534	protein K63-linked ubiquitination	UBE2N	IDA		Human	PMID:21512573
Biological Process	GO:0070534	protein K63-linked ubiquitination	UBE2N	IMP		Human	PMID:25936802
Biological Process	GO:0070534	protein K63-linked ubiquitination	UBE2N	IDA		Human	PMID:31006531
Biological Process	GO:0070534	protein K63-linked ubiquitination	Ube2n	IDA		Mouse	MGI:MGI:6148454|PMID:22424771
Biological Process	GO:0070534	protein K63-linked ubiquitination	Ube2n	IDA		Mouse	MGI:MGI:5896692|PMID:28039360
Biological Process	GO:0000209	protein polyubiquitination	ube2na	IPI	UniProtKB:Q15819	Zfish	PMID:20556485
Biological Process	GO:0016567	protein ubiquitination	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0033182	regulation of histone ubiquitination	UBE2N	IMP		Human	PMID:17349954
Biological Process	GO:0050852	T cell receptor signaling pathway	UBE2N	IMP		Human	PMID:15125833
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Ube2n	IDA		Mouse	PMID:12039045

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern