Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UBE3A
  • Mouse genes Ube3a
  • Rat genes Ube3a
  • Zfish genes ube3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ube3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:O14599	Human	PMID:12207887
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P04637	Human	PMID:12620801
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P36799	Human	PMID:15890204
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P04637	Human	PMID:16493710
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06463	Human	PMID:16493710
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03372,UniProtKB:Q969T9	Human	PMID:16772533
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P04019	Human	PMID:17023019
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:Q77E16	Human	PMID:17023019
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:Q77E16	Human	PMID:17166906
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P55036	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:Q14566	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:22483108
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P04019	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06462	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06463	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:22898364
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06463	Human	PMID:22898364
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P36799	Human	PMID:22898364
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:23393263
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:O00327	Human	PMID:24728990
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P17735	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:26789255
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P04637	Human	PMID:26789255
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P55036	Human	PMID:29426014
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:Q14566	Human	PMID:29426014
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P17735	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:Q06413	Human	PMID:31988313
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:7624774
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06463	Human	PMID:7624774
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06931	Human	PMID:7624774
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P03126	Human	PMID:9467941
Molecular Function	GO:0005515	protein binding	UBE3A	IPI	UniProtKB:P06931	Human	PMID:9467941
Molecular Function	GO:0005515	protein binding	Ube3a	IPI	PR:P62838	Mouse	PMID:9182527
Molecular Function	GO:0005515	protein binding	Ube3a	IPI	PR:P19091	Mouse	PMID:16254014
Molecular Function	GO:0003713	transcription coactivator activity	Ube3a	IDA		Mouse	PMID:16254014
Molecular Function	GO:0061630	ubiquitin protein ligase activity	UBE3A	IMP		Human	PMID:7708685
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Ube3a	IDA		Mouse	PMID:9182527
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	UBE3A	IDA		Human	PMID:12890688
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	UBE3A	IDA		Human	PMID:24105792
Cellular Component	GO:0005829	cytosol	Ube3a	IDA		Mouse	PMID:9182527
Cellular Component	GO:0098978	glutamatergic synapse	Ube3a	IMP		Mouse	PMID:26166566
Cellular Component	GO:0098978	glutamatergic synapse	Ube3a	IDA		Mouse	PMID:26166566
Cellular Component	GO:0005634	nucleus	Ube3a	IDA		Mouse	PMID:9182527
Biological Process	GO:0030521	androgen receptor signaling pathway	Ube3a	IPI	PR:P19091	Mouse	PMID:16254014
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	Ube3a	IEP		Rat	PMID:25867122|RGD:11079590
Biological Process	GO:0035641	locomotory exploration behavior	Ube3a	IMP		Rat	PMID:32066685|RGD:126790466
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Ube3a	IDA		Mouse	PMID:26166566
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Ube3a	IMP		Mouse	PMID:26166566
Biological Process	GO:0061743	motor learning	Ube3a	IMP		Rat	PMID:32066685|RGD:126790466
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	Ube3a	IMP		Rat	PMID:25867122|RGD:11079590
Biological Process	GO:0001541	ovarian follicle development	Ube3a	IMP	MGI:MGI:2181811	Mouse	PMID:11756548
Biological Process	GO:1905528	positive regulation of Golgi lumen acidification	Ube3a	IMP		Mouse	MGI:MGI:5486513|PMID:23447592
Biological Process	GO:1905528	positive regulation of Golgi lumen acidification	Ube3a	IMP		Rat	PMID:23447592|RGD:15023469
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Ube3a	IMP	MGI:MGI:2181811	Mouse	PMID:16254014
Biological Process	GO:0031398	positive regulation of protein ubiquitination	UBE3A	IDA		Human	PMID:17108031
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ube3a	IGI	MGI:MGI:88064	Mouse	PMID:16254014
Biological Process	GO:0050847	progesterone receptor signaling pathway	UBE3A	IDA		Human	PMID:16772533
Biological Process	GO:0060736	prostate gland growth	Ube3a	IMP	MGI:MGI:2181811	Mouse	PMID:11756548
Biological Process	GO:0060736	prostate gland growth	Ube3a	IMP	MGI:MGI:2181811	Mouse	PMID:16254014
Biological Process	GO:0051865	protein autoubiquitination	UBE3A	IDA		Human	PMID:24105792
Biological Process	GO:0070936	protein K48-linked ubiquitination	UBE3A	IDA		Human	PMID:12890688
Biological Process	GO:0016567	protein ubiquitination	Ube3a	IDA		Mouse	PMID:9182527
Biological Process	GO:0042752	regulation of circadian rhythm	UBE3A	IMP		Human	PMID:24728990
Biological Process	GO:0042752	regulation of circadian rhythm	Ube3a	IMP		Mouse	MGI:MGI:5607382|PMID:24728990
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	UBE3A	IMP		Human	PMID:24728990
Biological Process	GO:0042220	response to cocaine	Ube3a	IEP		Rat	PMID:24810662|RGD:11667955
Biological Process	GO:0042542	response to hydrogen peroxide	Ube3a	IEP		Rat	PMID:17883392|RGD:12879392
Biological Process	GO:0032570	response to progesterone	UBE3A	IDA		Human	PMID:16772533
Biological Process	GO:0035037	sperm entry	Ube3a	IMP	MGI:MGI:2181811	Mouse	PMID:11756548
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Ube3a	IDA		Mouse	PMID:16254014

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern