Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UBR2
  • Mouse genes Ubr2
  • Rat genes Ubr2
  • Zfish genes ubr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ubr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140852	histone ubiquitin ligase activity	Ubr2	IDA		Mouse	MGI:MGI:4431162|PMID:20080676
Molecular Function	GO:0070728	leucine binding	UBR2	IDA		Human	PMID:20298436
Molecular Function	GO:0005515	protein binding	UBR2	IPI	UniProtKB:P12504	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	UBR2	IPI	UniProtKB:P54252	Human	PMID:30455355
Molecular Function	GO:0005515	protein binding	Ubr2	IPI	UniProtKB:P11260	Mouse	MGI:MGI:5912961|PMID:28806172
Molecular Function	GO:0005515	protein binding	Ubr2	IPI	PR:O70481	Mouse	PMID:11689692
Molecular Function	GO:0005515	protein binding	Ubr2	IPI	PR:Q99MV2	Mouse	PMID:21103378
Molecular Function	GO:0005515	protein binding	Ubr2	IPI	PR:P63147	Mouse	PMID:14585983
Molecular Function	GO:0005515	protein binding	Ubr2	IPI	PR:Q9D5S1	Mouse	PMID:21103378
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Ubr2	IDA		Mouse	MGI:MGI:6716971|PMID:31268597
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Ubr2	IGI	MGI:MGI:1277977	Mouse	PMID:11689692
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Ubr2	IDA		Mouse	PMID:14585983
Cellular Component	GO:0000785	chromatin	Ubr2	IDA		Mouse	MGI:MGI:4431162|PMID:20080676
Cellular Component	GO:0000151	ubiquitin ligase complex	Ubr2	IGI	MGI:MGI:1277977	Mouse	PMID:11689692
Biological Process	GO:0071233	cellular response to leucine	UBR2	IDA		Human	PMID:20298436
Biological Process	GO:0031507	heterochromatin formation	Ubr2	IDA		Mouse	MGI:MGI:4431162|PMID:20080676
Biological Process	GO:0007141	male meiosis I	Ubr2	IMP	MGI:MGI:2682037	Mouse	PMID:14585983
Biological Process	GO:0007140	male meiotic nuclear division	Ubr2	IMP		Mouse	MGI:MGI:5908463|PMID:28708824
Biological Process	GO:0032007	negative regulation of TOR signaling	UBR2	IMP		Human	PMID:20298436
Biological Process	GO:0010529	negative regulation of transposition	Ubr2	IMP		Mouse	MGI:MGI:5912961|PMID:28806172
Biological Process	GO:0007131	reciprocal meiotic recombination	Ubr2	IMP		Mouse	MGI:MGI:5908463|PMID:28708824
Biological Process	GO:0007283	spermatogenesis	Ubr2	IMP		Mouse	MGI:MGI:5908463|PMID:28708824
Biological Process	GO:0007283	spermatogenesis	Ubr2	IMP	MGI:MGI:2682037	Mouse	PMID:14585983
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Ubr2	IDA		Mouse	PMID:14585983

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern