Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UBR5
  • Mouse genes Ubr5
  • Rat genes Ubr5
  • Zfish genes ubr5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ubr5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	UBR5	IPI	UniProtKB:P06401	Human	PMID:12011095
Molecular Function	GO:0005515	protein binding	UBR5	IPI	UniProtKB:P52294	Human	PMID:12011095
Molecular Function	GO:0005515	protein binding	UBR5	IPI	UniProtKB:Q99828	Human	PMID:12011095
Molecular Function	GO:0005515	protein binding	UBR5	IPI	UniProtKB:Q9BPZ3	Human	PMID:16601676
Molecular Function	GO:0005515	protein binding	UBR5	IPI	UniProtKB:P35222	Human	PMID:21118991
Molecular Function	GO:0005515	protein binding	UBR5	IPI	UniProtKB:P49841	Human	PMID:21118991
Molecular Function	GO:0005515	protein binding	Ubr5	IPI	PR:Q3U2S4	Mouse	PMID:25470037
Molecular Function	GO:0005515	protein binding	Ubr5	IPI	PR:P51450-2	Mouse	PMID:25470037
Molecular Function	GO:0019904	protein domain specific binding	Ubr5	IDA		Rat	PMID:16554297|RGD:8693691
Molecular Function	GO:0061630	ubiquitin protein ligase activity	UBR5	IDA		Human	PMID:28689657
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Ubr5	IDA		Rat	PMID:12239083|RGD:625681
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Ubr5	IMP		Rat	PMID:7708685|RGD:10047284
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	UBR5	IDA		Human	PMID:21118991
Cellular Component	GO:0005829	cytosol	UBR5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ubr5	IDA		Rat	PMID:12239083|RGD:625681
Cellular Component	GO:0016020	membrane	UBR5	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	UBR5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	UBR5	IDA		Human	PMID:12011095
Cellular Component	GO:0005634	nucleus	UBR5	IDA		Human	PMID:21118991
Cellular Component	GO:0005634	nucleus	UBR5	IDA		Human	PMID:28689657
Cellular Component	GO:0048471	perinuclear region of cytoplasm	UBR5	IDA		Human	PMID:18076571
Cellular Component	GO:0032991	protein-containing complex	UBR5	IDA		Human	PMID:18076571
Biological Process	GO:0006974	DNA damage response	UBR5	IDA		Human	PMID:12011095
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	UBR5	IMP		Human	PMID:22884692
Biological Process	GO:2000780	negative regulation of double-strand break repair	UBR5	IMP		Human	PMID:22884692
Biological Process	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	UBR5	IMP		Human	PMID:22884692
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Ubr5	IGI	MGI:MGI:1859615	Mouse	PMID:25470037
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	UBR5	IMP		Human	PMID:21118991
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	UBR5	IMP		Human	PMID:28689657
Biological Process	GO:0010628	positive regulation of gene expression	UBR5	IDA		Human	PMID:18076571
Biological Process	GO:0042307	positive regulation of protein import into nucleus	UBR5	IMP		Human	PMID:21118991
Biological Process	GO:0050847	progesterone receptor signaling pathway	UBR5	IDA		Human	PMID:12011095
Biological Process	GO:0070936	protein K48-linked ubiquitination	UBR5	IDA		Human	PMID:28689657
Biological Process	GO:0000209	protein polyubiquitination	UBR5	IDA		Human	PMID:21118991
Biological Process	GO:0000209	protein polyubiquitination	UBR5	IDA		Human	PMID:28689657
Biological Process	GO:0016567	protein ubiquitination	Ubr5	IDA		Rat	PMID:12239083|RGD:625681
Biological Process	GO:0031647	regulation of protein stability	Ubr5	IMP		Mouse	PMID:25470037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern