Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UCHL5
  • Mouse genes Uchl5
  • Rat genes Uchl5
  • Zfish genes uchl5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Uchl5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	UCHL5	IDA		Human	PMID:18922472
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	UCHL5	IMP		Human	PMID:28992318
Molecular Function	GO:0004866	endopeptidase inhibitor activity	UCHL5	IMP		Human	PMID:18162577
Molecular Function	GO:0070628	proteasome binding	UCHL5	IDA		Human	PMID:18162577
Molecular Function	GO:0070628	proteasome binding	UCHL5	IDA		Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q99871	Human	PMID:11163772
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P60900	Human	PMID:16990800
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q13200	Human	PMID:16990800
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:16990800
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P55036	Human	PMID:17139257
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:17139257
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P0C1Z6	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P55036	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P60900	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q13200	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q6P4R8	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q8NBZ0	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q9H981	Human	PMID:18922472
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P55036	Human	PMID:19490896
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P60900	Human	PMID:19490896
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q13200	Human	PMID:19490896
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:19490896
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P0C1Z6	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:P55036	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q13200	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q6P4R8	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q8NBZ0	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q8NBZ0	Human	PMID:21303910
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:O96006	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q6P4R8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	UCHL5	IPI	UniProtKB:Q16186	Human	PMID:31515488
Molecular Function	GO:0003723	RNA binding	UCHL5	HDA		Human	PMID:22658674
Cellular Component	GO:0005829	cytosol	UCHL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	UCHL5	IDA		Human	PMID:18922472
Cellular Component	GO:0031597	cytosolic proteasome complex	Uchl5	IDA		Rat	PMID:19609968|RGD:9480236
Cellular Component	GO:0031011	Ino80 complex	UCHL5	IDA		Human	PMID:21303910
Cellular Component	GO:0005730	nucleolus	UCHL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	UCHL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	UCHL5	IDA		Human	PMID:18922472
Biological Process	GO:0006338	chromatin remodeling	UCHL5	IDA		Human	PMID:21303910
Biological Process	GO:1904888	cranial skeletal system development	uchl5	IMP	ZFIN:ZDB-MRPHLNO-100225-33	Zfish	PMID:28450118
Biological Process	GO:0048853	forebrain morphogenesis	Uchl5	IMP		Mouse	MGI:MGI:4849324|PMID:21048919
Biological Process	GO:0021670	lateral ventricle development	Uchl5	IMP		Mouse	MGI:MGI:4849324|PMID:21048919
Biological Process	GO:0030901	midbrain development	Uchl5	IMP		Mouse	MGI:MGI:4849324|PMID:21048919
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	UCHL5	IMP		Human	PMID:23770237
Biological Process	GO:0045739	positive regulation of DNA repair	Uchl5	IDA		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	UCHL5	IMP		Human	PMID:27641337
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	UCHL5	IMP		Human	PMID:28992318
Biological Process	GO:1904507	positive regulation of telomere maintenance in response to DNA damage	Uchl5	IMP		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0016579	protein deubiquitination	UCHL5	IDA		Human	PMID:18922472
Biological Process	GO:0016579	protein deubiquitination	UCHL5	IMP		Human	PMID:28992318
Biological Process	GO:0051726	regulation of cell cycle	UCHL5	IMP		Human	PMID:26340092
Biological Process	GO:0033044	regulation of chromosome organization	UCHL5	IMP		Human	PMID:26340092
Biological Process	GO:0006282	regulation of DNA repair	Uchl5	IDA		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0006275	regulation of DNA replication	UCHL5	IMP		Human	PMID:25016522
Biological Process	GO:0060382	regulation of DNA strand elongation	UCHL5	IMP		Human	PMID:25016522
Biological Process	GO:0045995	regulation of embryonic development	Uchl5	IMP		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	UCHL5	IMP		Human	PMID:18162577
Biological Process	GO:0000723	telomere maintenance	Uchl5	IMP		Mouse	MGI:MGI:5638510|PMID:23979016

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern