Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UCP2
  • Mouse genes Ucp2
  • Rat genes Ucp2
  • Zfish genes ucp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ucp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015297	antiporter activity	UCP2	IDA		Human	PMID:24395786
Molecular Function	GO:0015183	L-aspartate transmembrane transporter activity	UCP2	IDA		Human	PMID:24395786
Molecular Function	GO:0015140	malate transmembrane transporter activity	UCP2	IDA		Human	PMID:24395786
Molecular Function	GO:0015131	oxaloacetate transmembrane transporter activity	UCP2	IDA		Human	PMID:24395786
Molecular Function	GO:0140787	phosphate ion uniporter activity	UCP2	IDA		Human	PMID:24395786
Molecular Function	GO:0005515	protein binding	UCP2	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0042803	protein homodimerization activity	UCP2	IDA		Human	PMID:33373220
Molecular Function	GO:0015078	proton transmembrane transporter activity	UCP2	IDA		Human	PMID:33373220
Molecular Function	GO:0008271	secondary active sulfate transmembrane transporter activity	UCP2	IDA		Human	PMID:24395786
Cellular Component	GO:0005737	cytoplasm	Ucp2	IDA		Rat	PMID:22550338|RGD:10045656
Cellular Component	GO:0031966	mitochondrial membrane	Ucp2	IDA		Mouse	MGI:MGI:6856556|PMID:34644537
Cellular Component	GO:0005739	mitochondrion	UCP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Ucp2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Ucp2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Ucp2	IDA		Rat	PMID:12372827|RGD:727448
Biological Process	GO:0007568	aging	Ucp2	IEP		Rat	PMID:19041646|RGD:7204432
Biological Process	GO:0015740	C4-dicarboxylate transport	UCP2	IMP		Human	PMID:24395786
Biological Process	GO:0034198	cellular response to amino acid starvation	Ucp2	IEP		Rat	PMID:18692019|RGD:7240714
Biological Process	GO:0071333	cellular response to glucose stimulus	Ucp2	IMP		Mouse	MGI:MGI:5766079|PMID:26919426
Biological Process	GO:0071333	cellular response to glucose stimulus	Ucp2	IEP		Rat	PMID:18692019|RGD:7240714
Biological Process	GO:0032870	cellular response to hormone stimulus	Ucp2	IEP		Rat	PMID:18079609|RGD:2313533
Biological Process	GO:0032869	cellular response to insulin stimulus	Ucp2	IEP		Rat	PMID:18079609|RGD:2313533
Biological Process	GO:0071284	cellular response to lead ion	Ucp2	IEP		Rat	PMID:33576715|RGD:155582212
Biological Process	GO:0007565	female pregnancy	Ucp2	IEP		Rat	PMID:20393169|RGD:5133720
Biological Process	GO:0006541	glutamine metabolic process	UCP2	IMP		Human	PMID:24395786
Biological Process	GO:0006096	glycolytic process	UCP2	IMP		Human	PMID:24395786
Biological Process	GO:0097421	liver regeneration	Ucp2	IEP		Rat	PMID:19104935|RGD:7204431
Biological Process	GO:0030225	macrophage differentiation	Ucp2	IMP		Mouse	MGI:MGI:6856556|PMID:34644537
Biological Process	GO:0000266	mitochondrial fission	Ucp2	IMP		Mouse	MGI:MGI:5766079|PMID:26919426
Biological Process	GO:1990542	mitochondrial transmembrane transport	UCP2	IMP		Human	PMID:24395786
Biological Process	GO:0006839	mitochondrial transport	Ucp2	IDA		Rat	PMID:12372827|RGD:727448
Biological Process	GO:0043066	negative regulation of apoptotic process	Ucp2	IMP		Rat	PMID:18703058|RGD:7204433
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Ucp2	IMP		Rat	PMID:21172424|RGD:7204422
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ucp2	IMP		Mouse	PMID:22956852
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ucp2	IMP		Mouse	MGI:MGI:6101140|PMID:28130074
Biological Process	GO:0072593	reactive oxygen species metabolic process	Ucp2	IMP		Mouse	MGI:MGI:5766079|PMID:26919426
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Ucp2	IMP		Mouse	MGI:MGI:5436371|PMID:22736029
Biological Process	GO:0070542	response to fatty acid	Ucp2	IEP		Rat	PMID:18079609|RGD:2313533
Biological Process	GO:0009749	response to glucose	Ucp2	IEP		Rat	PMID:18079609|RGD:2313533
Biological Process	GO:0001666	response to hypoxia	UCP2	IDA		Human	PMID:22292025
Biological Process	GO:0001666	response to hypoxia	Ucp2	IEP		Rat	PMID:17704287|RGD:2302404
Biological Process	GO:0000303	response to superoxide	Ucp2	IDA		Rat	PMID:12372827|RGD:727448

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern