Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UGT1A1
  • Mouse genes Ugt1a1
  • Rat genes Ugt1a1
  • Zfish genes ugt1a7,ugt1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ugt1a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	UGT1A1	IPI	UniProtKB:O60656|UniProtKB:P19224|UniProtKB:P22310|UniProtKB:P35503|UniProtKB:Q9HAW7|UniProtKB:Q9HAW8|UniProtKB:Q9HAW9	Human	PMID:17179145
Molecular Function	GO:0019899	enzyme binding	Ugt1a1	IDA		Rat	PMID:17965520|RGD:2317073
Molecular Function	GO:0004857	enzyme inhibitor activity	UGT1A1	IDA		Human	PMID:19996319
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:15472229
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:17179145
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:18052087
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:18719240
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:1898728
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:19830808
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:19996319
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:20056724
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:20308471
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A1	IDA		Human	PMID:22579593
Molecular Function	GO:0015020	glucuronosyltransferase activity	Ugt1a1	IDA		Rat	PMID:11829457|RGD:70480
Molecular Function	GO:0015020	glucuronosyltransferase activity	ugt1ab	IDA		Zfish	PMID:24728488
Molecular Function	GO:0015020	glucuronosyltransferase activity	ugt1a7	IDA		Zfish	PMID:24728488
Molecular Function	GO:0042803	protein homodimerization activity	UGT1A1	IDA		Human	PMID:17179145
Molecular Function	GO:0001972	retinoic acid binding	UGT1A1	IDA		Human	PMID:20308471
Molecular Function	GO:0005496	steroid binding	UGT1A1	IDA		Human	PMID:19996319
Cellular Component	GO:0070069	cytochrome complex	Ugt1a1	IDA		Rat	PMID:17965520|RGD:2317073
Cellular Component	GO:0005783	endoplasmic reticulum	UGT1A1	IDA		Human	PMID:17179145
Cellular Component	GO:0005783	endoplasmic reticulum	Ugt1a1	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0034663	endoplasmic reticulum chaperone complex	Ugt1a1	IDA		Mouse	MGI:MGI:5613481|PMID:12475965
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Ugt1a1	IDA		Rat	PMID:9841869|RGD:1600450
Cellular Component	GO:0005886	plasma membrane	Ugt1a1	IDA		Mouse	PMID:12951053
Biological Process	GO:0006953	acute-phase response	Ugt1a1	IEP		Rat	PMID:9737578|RGD:6482857
Biological Process	GO:0031100	animal organ regeneration	Ugt1a1	IEP		Rat	PMID:16222444|RGD:2317021
Biological Process	GO:0070980	biphenyl catabolic process	Ugt1a1	IDA		Rat	PMID:16006569|RGD:1600442
Biological Process	GO:0052695	cellular glucuronidation	UGT1A1	IDA		Human	PMID:15472229
Biological Process	GO:0052695	cellular glucuronidation	UGT1A1	IDA		Human	PMID:17179145
Biological Process	GO:0052695	cellular glucuronidation	UGT1A1	IDA		Human	PMID:18719240
Biological Process	GO:0052695	cellular glucuronidation	UGT1A1	IDA		Human	PMID:19830808
Biological Process	GO:0052695	cellular glucuronidation	UGT1A1	IDA		Human	PMID:22579593
Biological Process	GO:0052695	cellular glucuronidation	Ugt1a1	IDA		Rat	PMID:9224784|RGD:10769346
Biological Process	GO:0071392	cellular response to estradiol stimulus	Ugt1a1	IEP		Rat	PMID:9327435|RGD:10769353
Biological Process	GO:0071361	cellular response to ethanol	Ugt1a1	IEP		Rat	PMID:11412396|RGD:2317026
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Ugt1a1	IEP		Rat	PMID:10100302|RGD:2317062
Biological Process	GO:0032870	cellular response to hormone stimulus	Ugt1a1	IEP		Rat	PMID:10100302|RGD:2317062
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Ugt1a1	IEP		Rat	PMID:8632018|RGD:10769355
Biological Process	GO:0008210	estrogen metabolic process	UGT1A1	IDA		Human	PMID:15472229
Biological Process	GO:0008210	estrogen metabolic process	UGT1A1	IDA		Human	PMID:18719240
Biological Process	GO:0008210	estrogen metabolic process	UGT1A1	IDA		Human	PMID:19830808
Biological Process	GO:0051552	flavone metabolic process	UGT1A1	IDA		Human	PMID:18052087
Biological Process	GO:0052696	flavonoid glucuronidation	UGT1A1	IDA		Human	PMID:20056724
Biological Process	GO:0052696	flavonoid glucuronidation	Ugt1a1	IDA		Rat	PMID:8806713|RGD:10769352
Biological Process	GO:0001889	liver development	Ugt1a1	IEP		Rat	PMID:16310220|RGD:2315453
Biological Process	GO:0001889	liver development	Ugt1a1	IEP		Rat	PMID:18938141|RGD:2317023
Biological Process	GO:0045471	response to ethanol	Ugt1a1	IEP		Rat	PMID:11848303|RGD:1600446
Biological Process	GO:0051384	response to glucocorticoid	Ugt1a1	IEP		Rat	PMID:11829457|RGD:70480
Biological Process	GO:0032496	response to lipopolysaccharide	Ugt1a1	IEP		Rat	PMID:19356101|RGD:2315452
Biological Process	GO:0007584	response to nutrient	Ugt1a1	IEP		Rat	PMID:11299074|RGD:1600448
Biological Process	GO:0014070	response to organic cyclic compound	Ugt1a1	IEP		Rat	PMID:11854140|RGD:2317024
Biological Process	GO:0010033	response to organic substance	Ugt1a1	IMP		Rat	PMID:15921999|RGD:1600444
Biological Process	GO:0010033	response to organic substance	Ugt1a1	IEP		Rat	PMID:19045937|RGD:2317071
Biological Process	GO:0042594	response to starvation	Ugt1a1	IEP		Rat	PMID:9841869|RGD:1600450
Biological Process	GO:0048545	response to steroid hormone	Ugt1a1	IEP		Rat	PMID:11086234|RGD:1600449
Biological Process	GO:0009410	response to xenobiotic stimulus	Ugt1a1	IEP		Rat	PMID:11829457|RGD:70480
Biological Process	GO:0052697	xenobiotic glucuronidation	UGT1A1	IDA		Human	PMID:15472229
Biological Process	GO:0052697	xenobiotic glucuronidation	UGT1A1	IDA		Human	PMID:18719240
Biological Process	GO:0052697	xenobiotic glucuronidation	UGT1A1	IDA		Human	PMID:19830808
Biological Process	GO:0052697	xenobiotic glucuronidation	UGT1A1	IDA		Human	PMID:20056724
Biological Process	GO:0052697	xenobiotic glucuronidation	Ugt1a1	IDA		Rat	PMID:8806713|RGD:10769352

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern