Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UGT1A6
  • Mouse genes Ugt1a6a
  • Rat genes Ugt1a6
  • Zfish genes ugt1a7,ugt1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ugt1a6a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046559	alpha-glucuronidase activity	Ugt1a6a	IDA		Mouse	PMID:10606751
Molecular Function	GO:0019899	enzyme binding	UGT1A6	IPI	UniProtKB:P22309	Human	PMID:17179145
Molecular Function	GO:0015020	glucuronosyltransferase activity	UGT1A6	IDA		Human	PMID:22579593
Molecular Function	GO:0015020	glucuronosyltransferase activity	Ugt1a6a	IDA		Mouse	PMID:8068691
Molecular Function	GO:0015020	glucuronosyltransferase activity	Ugt1a6	IDA		Rat	PMID:11854153|RGD:634454
Molecular Function	GO:0015020	glucuronosyltransferase activity	ugt1ab	IDA		Zfish	PMID:24728488
Molecular Function	GO:0015020	glucuronosyltransferase activity	ugt1a7	IDA		Zfish	PMID:24728488
Molecular Function	GO:0042803	protein homodimerization activity	UGT1A6	IDA		Human	PMID:17179145
Molecular Function	GO:0044877	protein-containing complex binding	Ugt1a6	IDA		Rat	PMID:17965520|RGD:2317073
Cellular Component	GO:0005783	endoplasmic reticulum	UGT1A6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	UGT1A6	IDA		Human	PMID:17179145
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	UGT1A6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Ugt1a6	IDA		Rat	PMID:17965520|RGD:2317073
Cellular Component	GO:0005743	mitochondrial inner membrane	Ugt1a6a	HDA		Mouse	PMID:12865426
Cellular Component	GO:0032991	protein-containing complex	Ugt1a6	IDA		Rat	PMID:17965520|RGD:2317073
Biological Process	GO:0018880	4-chlorobiphenyl metabolic process	Ugt1a6	IDA		Rat	PMID:16006569|RGD:1600442
Biological Process	GO:0052695	cellular glucuronidation	UGT1A6	IDA		Human	PMID:22579593
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Ugt1a6	IDA		Rat	PMID:18039810|RGD:2317072
Biological Process	GO:0032870	cellular response to hormone stimulus	Ugt1a6	IEP		Rat	PMID:10100302|RGD:2317062
Biological Process	GO:0019585	glucuronate metabolic process	Ugt1a6a	IDA		Mouse	PMID:8068691
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	Ugt1a6a	IGI	MGI:MGI:1353434	Mouse	PMID:10606751
Biological Process	GO:0001889	liver development	Ugt1a6	IEP		Rat	PMID:18938141|RGD:2317023
Biological Process	GO:0032496	response to lipopolysaccharide	Ugt1a6	IEP		Rat	PMID:19356101|RGD:2315452
Biological Process	GO:0014070	response to organic cyclic compound	Ugt1a6	IEP		Rat	PMID:10845702|RGD:2317022
Biological Process	GO:0014070	response to organic cyclic compound	Ugt1a6	IEP		Rat	PMID:11854140|RGD:2317024
Biological Process	GO:0043434	response to peptide hormone	Ugt1a6	IEP		Rat	PMID:11408524|RGD:2317074
Biological Process	GO:0006805	xenobiotic metabolic process	UGT1A6	IDA		Human	PMID:3141926

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern