Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UHRF1
  • Mouse genes Uhrf1
  • Rat genes Uhrf1
  • Zfish genes uhrf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Uhrf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	UHRF1	IDA		Human	PMID:10646863
Molecular Function	GO:0044729	hemi-methylated DNA-binding	UHRF1	IDA		Human	PMID:17673620
Molecular Function	GO:0044729	hemi-methylated DNA-binding	Uhrf1	IDA		Mouse	MGI:MGI:3768689|PMID:17994007
Molecular Function	GO:0042393	histone binding	UHRF1	IDA		Human	PMID:21777816
Molecular Function	GO:0042393	histone binding	Uhrf1	IDA		Mouse	MGI:MGI:3038029|PMID:14993289
Molecular Function	GO:0042802	identical protein binding	Uhrf1	IPI	UniProtKB:Q8VDF2	Mouse	MGI:MGI:3038029|PMID:14993289
Molecular Function	GO:0008327	methyl-CpG binding	UHRF1	IDA		Human	PMID:15361834
Molecular Function	GO:0008327	methyl-CpG binding	UHRF1	IDA		Human	PMID:21029866
Molecular Function	GO:0035064	methylated histone binding	UHRF1	IDA		Human	PMID:17967883
Molecular Function	GO:0035064	methylated histone binding	UHRF1	IDA		Human	PMID:21029866
Molecular Function	GO:0035064	methylated histone binding	UHRF1	IDA		Human	PMID:21489993
Molecular Function	GO:0035064	methylated histone binding	Uhrf1	IDA		Mouse	MGI:MGI:5448517|PMID:21489993
Molecular Function	GO:0003676	nucleic acid binding	UHRF1	EXP		Human	PMID:18772889
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:Q6BDS2	Human	PMID:15361834
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:P26358	Human	PMID:17673620
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:P26358	Human	PMID:17934516
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:P26358	Human	PMID:19798101
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:Q9UBC3	Human	PMID:19798101
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:Q9Y6K1	Human	PMID:19798101
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:Q93009	Human	PMID:21745816
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:P29590	Human	PMID:22945642
Molecular Function	GO:0005515	protein binding	UHRF1	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	Uhrf1	IPI	UniProtKB:P13864	Mouse	MGI:MGI:3768689|PMID:17994007
Molecular Function	GO:0005515	protein binding	Uhrf1	IPI	UniProtKB:Q6A4J8	Mouse	MGI:MGI:5442500|PMID:21268065
Molecular Function	GO:0005515	protein binding	Uhrf1	IPI	UniProtKB:Q810Y8	Mouse	MGI:MGI:5908741|PMID:28604677
Molecular Function	GO:0005515	protein binding	Uhrf1	IPI	PR:Q8VDF2	Mouse	PMID:18692478
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Uhrf1	IDA		Mouse	PMID:14993289
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	UHRF1	IDA		Human	PMID:17967883
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	UHRF1	IDA		Human	PMID:21745816
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	UHRF1	IDA		Human	PMID:22945642
Molecular Function	GO:0008270	zinc ion binding	UHRF1	IDA		Human	PMID:21777816
Cellular Component	GO:0000785	chromatin	UHRF1	IDA		Human	PMID:17673620
Cellular Component	GO:0000785	chromatin	Uhrf1	IDA		Mouse	MGI:MGI:3038029|PMID:14993289
Cellular Component	GO:0000785	chromatin	Uhrf1	IDA		Mouse	MGI:MGI:3768689|PMID:17994007
Cellular Component	GO:0005737	cytoplasm	uhrf1	IDA		Zfish	PMID:22072796
Cellular Component	GO:0031410	cytoplasmic vesicle	Uhrf1	IDA		Rat	PMID:21734099|RGD:9587431
Cellular Component	GO:0000791	euchromatin	UHRF1	IDA		Human	PMID:21777816
Cellular Component	GO:0000792	heterochromatin	UHRF1	IDA		Human	PMID:17967883
Cellular Component	GO:0000792	heterochromatin	UHRF1	IDA		Human	PMID:21489993
Cellular Component	GO:0000792	heterochromatin	UHRF1	IDA		Human	PMID:21777816
Cellular Component	GO:0000792	heterochromatin	Uhrf1	IDA		Mouse	MGI:MGI:5448517|PMID:21489993
Cellular Component	GO:0000792	heterochromatin	Uhrf1	IDA		Mouse	PMID:17994007
Cellular Component	GO:0000792	heterochromatin	Uhrf1	IDA		Mouse	PMID:18692478
Cellular Component	GO:0016363	nuclear matrix	Uhrf1	IDA		Mouse	MGI:MGI:3038029|PMID:14993289
Cellular Component	GO:0005654	nucleoplasm	UHRF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	UHRF1	IDA		Human	PMID:10646863
Cellular Component	GO:0005634	nucleus	Uhrf1	IDA		Mouse	PMID:17994007
Cellular Component	GO:0005634	nucleus	uhrf1	IDA		Zfish	PMID:22072796
Cellular Component	GO:0005886	plasma membrane	Uhrf1	IDA		Rat	PMID:21734099|RGD:9587431
Cellular Component	GO:0005657	replication fork	UHRF1	IDA		Human	PMID:17673620
Cellular Component	GO:0005657	replication fork	Uhrf1	IDA		Mouse	MGI:MGI:3768689|PMID:17994007
Biological Process	GO:0031100	animal organ regeneration	uhrf1	IMP	ZFIN:ZDB-GENO-070209-94	Zfish	PMID:17242348
Biological Process	GO:0010390	histone monoubiquitination	Uhrf1	IDA		Mouse	MGI:MGI:3038029|PMID:14993289
Biological Process	GO:0016574	histone ubiquitination	UHRF1	IDA		Human	PMID:17967883
Biological Process	GO:0006954	inflammatory response	uhrf1	IGI	ZFIN:ZDB-GENO-150617-6,ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:25730872
Biological Process	GO:0006954	inflammatory response	uhrf1	IMP	ZFIN:ZDB-GENO-150617-6	Zfish	PMID:25730872
Biological Process	GO:0060729	intestinal epithelial structure maintenance	uhrf1	IGI	ZFIN:ZDB-GENO-150617-6,ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:25730872
Biological Process	GO:0060729	intestinal epithelial structure maintenance	uhrf1	IMP	ZFIN:ZDB-GENO-150617-6	Zfish	PMID:25730872
Biological Process	GO:0002088	lens development in camera-type eye	uhrf1	IMP	ZFIN:ZDB-GENO-110330-8	Zfish	PMID:21126517
Biological Process	GO:0002088	lens development in camera-type eye	uhrf1	IMP	ZFIN:ZDB-GENO-040712-2	Zfish	PMID:15716491
Biological Process	GO:0002088	lens development in camera-type eye	uhrf1	IMP	ZFIN:ZDB-GENO-040712-3	Zfish	PMID:15716491
Biological Process	GO:0001889	liver development	uhrf1	IMP	ZFIN:ZDB-GENO-040712-2	Zfish	PMID:25564650
Biological Process	GO:0001889	liver development	uhrf1	IGI	ZFIN:ZDB-GENE-990714-15	Zfish	PMID:25564650
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	UHRF1	IMP		Human	PMID:17673620
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Uhrf1	IMP		Mouse	MGI:MGI:3768689|PMID:17994007
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Uhrf1	IMP		Mouse	MGI:MGI:5442505|PMID:17673620
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	uhrf1	IMP	ZFIN:ZDB-GENO-150617-6	Zfish	PMID:25730872
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	uhrf1	IMP		Zfish	PMID:20395551
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	UHRF1	IDA		Human	PMID:21777816
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Uhrf1	IDA		Mouse	MGI:MGI:5448517|PMID:21489993
Biological Process	GO:0051247	positive regulation of protein metabolic process	UHRF1	IDA		Human	PMID:10646863
Biological Process	GO:0051865	protein autoubiquitination	UHRF1	IDA		Human	PMID:17967883
Biological Process	GO:0051865	protein autoubiquitination	UHRF1	IDA		Human	PMID:21745816
Biological Process	GO:0051865	protein autoubiquitination	Uhrf1	IDA		Mouse	MGI:MGI:3038029|PMID:14993289
Biological Process	GO:0050678	regulation of epithelial cell proliferation	UHRF1	IMP		Human	PMID:15361834
Biological Process	GO:0043434	response to peptide hormone	Uhrf1	IEP		Rat	PMID:21734099|RGD:9587431
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	UHRF1	IDA		Human	PMID:22945642

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern