Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ULK1
  • Mouse genes Ulk1
  • Rat genes Ulk1
  • Zfish genes ulk1a,ulk1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ulk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051020	GTPase binding	ULK1	IPI	UniProtKB:A1A4Y4	Human	PMID:25891078
Molecular Function	GO:0051879	Hsp90 protein binding	Ulk1	IPI	UniProtKB:P08238|UniProtKB:P11499	Mouse	MGI:MGI:5607224|PMID:21855797
Molecular Function	GO:0042802	identical protein binding	ULK1	IPI	UniProtKB:O75385	Human	PMID:20562859
Molecular Function	GO:0042802	identical protein binding	ULK1	IPI	UniProtKB:O75385	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O95166	Human	PMID:11146101
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P60520	Human	PMID:11146101
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P04629	Human	PMID:17389358
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:18936157
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:19211835
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:19211835
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:19597335
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P54646	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P60520	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9BXW4	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9GZQ8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9H0R8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P54646	Human	PMID:21072212
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9Y478	Human	PMID:21072212
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9Y250	Human	PMID:22354037
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9P2M4	Human	PMID:22613832
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:23392225
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:23392225
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P42345	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9C0C7	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9C0C7-3	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9Y4K3	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9BXW4	Human	PMID:24290141
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9GZQ8	Human	PMID:24290141
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q92609	Human	PMID:24603492
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8NFG4	Human	PMID:25126726
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P0CI25	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8IYM9	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9C030	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9C035	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9Y577	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9C0C7	Human	PMID:25438055
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P42345	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P42858	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8N122	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9Y478	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9HC29	Human	PMID:25891078
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O15553	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P19474	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O15530	Human	PMID:26593251
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q96LT7-1	Human	PMID:27334615
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q96LT7-2	Human	PMID:27334615
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TEV9	Human	PMID:28195531
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q9Y484	Human	PMID:28561066
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:P16615|UniProtKB:Q9Y4P8	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2,UniProtKB:Q9Y4P8	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q96LT7-1	Human	PMID:29950492
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:31806350
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	ULK1	IPI	UniProtKB:O75143	Human	PMID:33450483
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:Q9ESK9	Mouse	MGI:MGI:3796758|PMID:18443221
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:P42859|UniProtKB:Q9JLN9	Mouse	MGI:MGI:5915363|PMID:25686248
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:Q8IVP5|UniProtKB:Q9DB70	Mouse	MGI:MGI:5619425|PMID:24671035
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:Q91YI1|UniProtKB:Q9ESK9	Mouse	MGI:MGI:3849242|PMID:19258318
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:Q16543|UniProtKB:Q61081	Mouse	MGI:MGI:5607224|PMID:21855797
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:Q9DB70|UniProtKB:Q9JLN9	Mouse	MGI:MGI:5700279|PMID:25980607
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	UniProtKB:P58004|UniProtKB:Q13501	Mouse	MGI:MGI:5586935|PMID:25040165
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	PR:F6SEU4	Mouse	PMID:15014045
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	PR:O08992	Mouse	PMID:15014045
Molecular Function	GO:0005515	protein binding	Ulk1	IPI	PR:Q64337	Mouse	PMID:17389358
Molecular Function	GO:0004672	protein kinase activity	Ulk1	IMP		Mouse	MGI:MGI:5319706|PMID:22539723
Molecular Function	GO:0004672	protein kinase activity	Ulk1	IDA		Mouse	PMID:10624947
Molecular Function	GO:0004672	protein kinase activity	Ulk1	IDA		Mouse	PMID:9600096
Molecular Function	GO:0019901	protein kinase binding	Ulk1	IPI	UniProtKB:Q5EG47|UniProtKB:Q9JLN9	Mouse	MGI:MGI:5285135|PMID:21258367
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:18936157
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:20921139
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:25126726
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:25891078
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:27103069
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:28821708
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	IDA		Human	PMID:31123703
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ULK1	EXP		Human	PMID:32320653
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ulk1	IDA		Mouse	MGI:MGI:3796758|PMID:18443221
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ulk1	IMP		Mouse	MGI:MGI:5607224|PMID:21855797
Molecular Function	GO:0044877	protein-containing complex binding	ULK1	IPI	UniProtKB:Q8N122	Human	PMID:19211835
Molecular Function	GO:0031267	small GTPase binding	ULK1	IPI	UniProtKB:Q9P2M4	Human	PMID:22613832
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	ULK1	IPI		Human	PMID:19597335
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	ULK1	IPI	UniProtKB:Q8TDY2	Human	PMID:19211835
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	Ulk1	IPI	UniProtKB:Q91YI1|UniProtKB:Q9ESK9	Mouse	MGI:MGI:3849242|PMID:19258318
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	Ulk1	IDA		Mouse	PMID:19211835
Cellular Component	GO:0005776	autophagosome	ULK1	IDA		Human	PMID:17595159
Cellular Component	GO:0005776	autophagosome	ULK1	IDA		Human	PMID:22456507
Cellular Component	GO:0030424	axon	Ulk1	IDA		Rat	PMID:25040536|RGD:11553820
Cellular Component	GO:0005737	cytoplasm	ULK1	IDA		Human	PMID:29487085
Cellular Component	GO:0005737	cytoplasm	Ulk1	IDA		Mouse	PMID:10624947
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Ulk1	IDA		Mouse	PMID:15014045
Cellular Component	GO:0005829	cytosol	ULK1	IDA		Human	PMID:11146101
Cellular Component	GO:0005829	cytosol	Ulk1	IDA		Mouse	MGI:MGI:3849242|PMID:19258318
Cellular Component	GO:0097629	extrinsic component of omegasome membrane	ULK1	IDA		Human	PMID:22885598
Cellular Component	GO:0097632	extrinsic component of phagophore assembly site membrane	ULK1	IDA		Human	PMID:22885598
Cellular Component	GO:0016020	membrane	Ulk1	IDA		Mouse	PMID:15014045
Cellular Component	GO:0043005	neuron projection	Ulk1	IDA		Mouse	PMID:10624947
Cellular Component	GO:0043005	neuron projection	Ulk1	IDA		Mouse	PMID:15014045
Cellular Component	GO:0043025	neuronal cell body	Ulk1	IDA		Mouse	PMID:10624947
Cellular Component	GO:0000407	phagophore assembly site	ULK1	IDA		Human	PMID:19597335
Cellular Component	GO:0000407	phagophore assembly site	Ulk1	IDA		Mouse	MGI:MGI:3849242|PMID:19258318
Cellular Component	GO:0000407	phagophore assembly site	Ulk1	IDA		Mouse	MGI:MGI:6810790|PMID:18936157
Cellular Component	GO:0000407	phagophore assembly site	Ulk1	IDA		Mouse	PMID:21220506
Cellular Component	GO:0034045	phagophore assembly site membrane	ULK1	IDA		Human	PMID:18936157
Cellular Component	GO:0034045	phagophore assembly site membrane	Ulk1	IDA		Mouse	MGI:MGI:3796758|PMID:18443221
Biological Process	GO:0000045	autophagosome assembly	ULK1	IDA		Human	PMID:19225151
Biological Process	GO:0000045	autophagosome assembly	ULK1	IDA		Human	PMID:28890335
Biological Process	GO:0000045	autophagosome assembly	Ulk1	IMP		Mouse	MGI:MGI:3849242|PMID:19258318
Biological Process	GO:0000045	autophagosome assembly	Ulk1	IDA		Mouse	MGI:MGI:6810791|PMID:19225151
Biological Process	GO:0006914	autophagy	ULK1	IMP		Human	PMID:17595159
Biological Process	GO:0006914	autophagy	ULK1	IDA		Human	PMID:18936157
Biological Process	GO:0006914	autophagy	ULK1	IDA		Human	PMID:25891078
Biological Process	GO:0006914	autophagy	ULK1	IGI	UniProtKB:Q8IYT8	Human	PMID:28389568
Biological Process	GO:0006914	autophagy	Ulk1	IMP		Mouse	MGI:MGI:5285135|PMID:21258367
Biological Process	GO:0006914	autophagy	Ulk1	IMP		Mouse	MGI:MGI:3796758|PMID:18443221
Biological Process	GO:0048675	axon extension	Ulk1	IMP		Mouse	PMID:17389358
Biological Process	GO:0007409	axonogenesis	Ulk1	IDA		Mouse	PMID:15014045
Biological Process	GO:0034198	cellular response to amino acid starvation	Ulk1	IGI	UniProtKB:O70405	Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0031669	cellular response to nutrient levels	Ulk1	IDA		Mouse	MGI:MGI:5285135|PMID:21258367
Biological Process	GO:0021707	cerebellar granule cell differentiation	Ulk1	IMP		Mouse	PMID:10624947
Biological Process	GO:0048668	collateral sprouting	Ulk1	IMP		Mouse	PMID:17389358
Biological Process	GO:0051649	establishment of localization in cell	Ulk1	IMP		Mouse	PMID:17389358
Biological Process	GO:0016236	macroautophagy	ULK1	IMP		Human	PMID:22354037
Biological Process	GO:0016236	macroautophagy	Ulk1	IGI	UniProtKB:O70405	Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0016236	macroautophagy	Ulk1	IMP		Mouse	PMID:21258367
Biological Process	GO:0000423	mitophagy	Ulk1	IMP		Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0008285	negative regulation of cell population proliferation	ULK1	IDA		Human	PMID:21795849
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ulk1	IDA		Mouse	MGI:MGI:6810792|PMID:21795849
Biological Process	GO:0048671	negative regulation of collateral sprouting	Ulk1	IMP		Mouse	PMID:17389358
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ULK1	IDA		Human	PMID:25126726
Biological Process	GO:0001764	neuron migration	Ulk1	IMP		Mouse	PMID:10624947
Biological Process	GO:0031175	neuron projection development	ULK1	IMP		Human	PMID:18007665
Biological Process	GO:0031175	neuron projection development	Ulk1	IMP		Mouse	PMID:10624947
Biological Process	GO:0031175	neuron projection development	Ulk1	IMP		Rat	PMID:18007665|RGD:2303352
Biological Process	GO:0031102	neuron projection regeneration	Ulk1	IMP		Rat	PMID:18007665|RGD:2303352
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ULK1	IDA		Human	PMID:25126726
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ULK1	IDA		Human	PMID:27103069
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Ulk1	IDA		Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ULK1	IDA		Human	PMID:27103069
Biological Process	GO:2000786	positive regulation of autophagosome assembly	Ulk1	IMP		Rat	PMID:23448468|RGD:13208863
Biological Process	GO:0010508	positive regulation of autophagy	ULK1	IDA		Human	PMID:25126726
Biological Process	GO:0010508	positive regulation of autophagy	ULK1	IDA		Human	PMID:29487085
Biological Process	GO:0010508	positive regulation of autophagy	ULK1	IDA		Human	PMID:35670107
Biological Process	GO:0010508	positive regulation of autophagy	Ulk1	IMP		Mouse	MGI:MGI:5319706|PMID:22539723
Biological Process	GO:0010508	positive regulation of autophagy	Ulk1	IDA		Mouse	MGI:MGI:6810791|PMID:19225151
Biological Process	GO:0046777	protein autophosphorylation	ULK1	IDA		Human	PMID:18936157
Biological Process	GO:0046777	protein autophosphorylation	ULK1	IDA		Human	PMID:19225151
Biological Process	GO:0046777	protein autophosphorylation	Ulk1	IDA		Mouse	MGI:MGI:5285135|PMID:21258367
Biological Process	GO:0046777	protein autophosphorylation	Ulk1	IDA		Mouse	PMID:9600096
Biological Process	GO:0046777	protein autophosphorylation	Ulk1	IDA		Mouse	PMID:10624947
Biological Process	GO:0008104	protein localization	ULK1	IMP		Human	PMID:16940348
Biological Process	GO:0006468	protein phosphorylation	ULK1	IDA		Human	PMID:19225151
Biological Process	GO:0006468	protein phosphorylation	Ulk1	IDA		Mouse	MGI:MGI:6810791|PMID:19225151
Biological Process	GO:0021933	radial glia guided migration of cerebellar granule cell	Ulk1	IMP		Mouse	PMID:10624947
Biological Process	GO:0007265	Ras protein signal transduction	Ulk1	IDA		Mouse	PMID:15014045
Biological Process	GO:0031623	receptor internalization	Ulk1	IMP		Mouse	PMID:17389358
Biological Process	GO:0010941	regulation of cell death	Ulk1	IGI	UniProtKB:O70405	Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0010468	regulation of gene expression	Ulk1	IGI	UniProtKB:Q9QY01	Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0016241	regulation of macroautophagy	ULK1	IDA		Human	PMID:20921139
Biological Process	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway	Ulk1	IMP		Mouse	PMID:17389358
Biological Process	GO:1903059	regulation of protein lipidation	ULK1	IDA		Human	PMID:19225151
Biological Process	GO:1903059	regulation of protein lipidation	Ulk1	IDA		Mouse	MGI:MGI:6810791|PMID:19225151
Biological Process	GO:0098780	response to mitochondrial depolarisation	Ulk1	IMP		Mouse	MGI:MGI:5607224|PMID:21855797
Biological Process	GO:0042594	response to starvation	Ulk1	IDA		Mouse	MGI:MGI:3796758|PMID:18443221

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern