Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UNC13A
  • Mouse genes Unc13a
  • Rat genes Unc13a
  • Zfish genes unc13a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Unc13a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005516	calmodulin binding	Unc13a	IDA		Mouse	PMID:31787876
Molecular Function	GO:0005516	calmodulin binding	Unc13a	IDA		Rat	PMID:19492809|RGD:11535108
Molecular Function	GO:0005516	calmodulin binding	Unc13a	IDA		Rat	PMID:20010694|RGD:11535090
Molecular Function	GO:0019992	diacylglycerol binding	Unc13a	IDA		Mouse	PMID:15123597
Molecular Function	GO:0042802	identical protein binding	Unc13a	IPI	RGD:619722	Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0042802	identical protein binding	Unc13a	IPI	UniProtKB:Q62768	Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	UniProtKB:Q8K3B1	Mouse	MGI:MGI:4452423|PMID:19996097
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	PR:Q9QYX7	Mouse	PMID:19812333
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	PR:P98078	Mouse	PMID:10488064
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	PR:Q7TN73	Mouse	PMID:19812333
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	UniProtKB:Q9JIR4	Rat	PMID:11343654|RGD:634478
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	UniProtKB:Q9JIS1	Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0005515	protein binding	Unc13a	IPI	RGD:2558|RGD:3784	Rat	PMID:8999968|RGD:2311135
Molecular Function	GO:0019904	protein domain specific binding	Unc13a	IDA		Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0044877	protein-containing complex binding	Unc13a	IDA		Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0000149	SNARE binding	Unc13a	IDA		Rat	PMID:18201107|RGD:2311133
Molecular Function	GO:0030507	spectrin binding	Unc13a	IPI	RGD:3751	Rat	PMID:9704016|RGD:70020
Molecular Function	GO:0019905	syntaxin binding	Unc13a	IDA		Rat	PMID:9895278|RGD:11535093
Molecular Function	GO:0017075	syntaxin-1 binding	Unc13a	IPI	RGD:3784	Rat	PMID:8999968|RGD:2311135
Molecular Function	GO:0017075	syntaxin-1 binding	Unc13a	IDA		Rat	PMID:9895278|RGD:11535093
Cellular Component	GO:0030424	axon	Unc13a	IDA		Mouse	PMID:23791195
Cellular Component	GO:0044305	calyx of Held	Unc13a	IDA		Mouse	PMID:23658173
Cellular Component	GO:0060076	excitatory synapse	Unc13a	IDA		Rat	PMID:19730411|RGD:8554379
Cellular Component	GO:0098978	glutamatergic synapse	Unc13a	IDA		Mouse	PMID:10440375
Cellular Component	GO:0098978	glutamatergic synapse	Unc13a	IMP		Mouse	PMID:10440375
Cellular Component	GO:0005798	Golgi-associated vesicle	Unc13a	IDA		Rat	PMID:22875941|RGD:14390063
Cellular Component	GO:0031594	neuromuscular junction	Unc13a	IDA		Mouse	PMID:15988013
Cellular Component	GO:0043005	neuron projection	Unc13a	IDA		Rat	PMID:7559667|RGD:634400
Cellular Component	GO:0098793	presynapse	Unc13a	IDA		Mouse	MGI:MGI:1341485|PMID:10440375
Cellular Component	GO:0098793	presynapse	Unc13a	IDA		Mouse	PMID:25609709
Cellular Component	GO:0048786	presynaptic active zone	Unc13a	IDA		Mouse	PMID:23658173
Cellular Component	GO:0048786	presynaptic active zone	Unc13a	IDA		Rat	PMID:22875941|RGD:14390063
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Unc13a	IDA		Rat	PMID:21712437|RGD:9850098
Cellular Component	GO:0042734	presynaptic membrane	Unc13a	IDA		Rat	PMID:8999968|RGD:2311135
Cellular Component	GO:0032991	protein-containing complex	Unc13a	IDA		Rat	PMID:16732694|RGD:2311136
Cellular Component	GO:0045202	synapse	Unc13a	IDA		Mouse	MGI:MGI:1341485|PMID:10440375
Cellular Component	GO:0045202	synapse	Unc13a	IDA		Mouse	PMID:23791195
Cellular Component	GO:0097060	synaptic membrane	Unc13a	IDA		Rat	PMID:9895278|RGD:11535093
Cellular Component	GO:0043195	terminal bouton	Unc13a	HDA		Rat	PMID:24876496|RGD:10047219
Biological Process	GO:0050435	amyloid-beta metabolic process	Unc13a	IMP	MGI:MGI:3051217	Mouse	PMID:15123597
Biological Process	GO:0061789	dense core granule priming	Unc13a	IGI	UniProtKB:Q4KUS2,UniProtKB:Q9Z1N9	Rat	PMID:26575293|RGD:12050107
Biological Process	GO:0060384	innervation	Unc13a	IGI	MGI:MGI:1342278	Mouse	PMID:15988013
Biological Process	GO:0060291	long-term synaptic potentiation	Unc13a	IMP		Rat	PMID:21849565|RGD:5686386
Biological Process	GO:0007528	neuromuscular junction development	Unc13a	IGI	MGI:MGI:1342278	Mouse	PMID:15988013
Biological Process	GO:0099011	neuronal dense core vesicle exocytosis	Unc13a	IMP		Mouse	MGI:MGI:5476894|PMID:23229896
Biological Process	GO:0007269	neurotransmitter secretion	Unc13a	IMP	MGI:MGI:2449468	Mouse	PMID:11792326
Biological Process	GO:0007269	neurotransmitter secretion	Unc13a	IDA		Rat	PMID:7559667|RGD:634400
Biological Process	GO:1903861	positive regulation of dendrite extension	UNC13A	IDA		Human	PMID:23999003
Biological Process	GO:1900451	positive regulation of glutamate receptor signaling pathway	Unc13a	IMP		Mouse	MGI:MGI:5795815|PMID:23070049
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	Unc13a	IMP	MGI:MGI:2449468	Mouse	PMID:11792326
Biological Process	GO:0031915	positive regulation of synaptic plasticity	Unc13a	IGI	UniProtKB:Q8K0T7,UniProtKB:Q9Z1N9	Mouse	MGI:MGI:5490921|PMID:23658173
Biological Process	GO:0099525	presynaptic dense core vesicle exocytosis	Unc13a	IGI	UniProtKB:Q9Z1N9	Mouse	MGI:MGI:5819330|PMID:26575293
Biological Process	GO:1902991	regulation of amyloid precursor protein catabolic process	Unc13a	IMP		Mouse	MGI:MGI:5795815|PMID:23070049
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Unc13a	IMP	MGI:MGI:2449468	Mouse	PMID:11832228
Biological Process	GO:0010807	regulation of synaptic vesicle priming	Unc13a	IDA		Rat	PMID:21689256|RGD:14390056
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Unc13a	IGI	MGI:MGI:1342278	Mouse	PMID:11792326
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Unc13a	IMP	MGI:MGI:2449468	Mouse	PMID:11832228
Biological Process	GO:0016081	synaptic vesicle docking	Unc13a	IGI	MGI:MGI:1342278	Mouse	PMID:19558619
Biological Process	GO:0016079	synaptic vesicle exocytosis	Unc13a	IDA		Mouse	PMID:10440375
Biological Process	GO:0016079	synaptic vesicle exocytosis	Unc13a	IMP		Mouse	PMID:10440375
Biological Process	GO:0016188	synaptic vesicle maturation	Unc13a	IMP	MGI:MGI:2449468	Mouse	PMID:10440375
Biological Process	GO:0016082	synaptic vesicle priming	Unc13a	IGI	UniProtKB:Q9Z1N9	Mouse	MGI:MGI:5617001|PMID:25374362
Biological Process	GO:0016082	synaptic vesicle priming	Unc13a	IMP		Mouse	MGI:MGI:2158113|PMID:11832228
Biological Process	GO:0016082	synaptic vesicle priming	Unc13a	IDA		Rat	PMID:21499244|RGD:5686389

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern