Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USH1C
  • Mouse genes Ush1c
  • Rat genes Ush1c
  • Zfish genes ush1c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ush1c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032029	myosin tail binding	Ush1c	IDA		Rat	PMID:23704327|RGD:8553853
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q8N6Y0	Human	PMID:11311560
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q8N1I0	Human	PMID:16464467
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:20142502
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q6PIF6	Human	PMID:24725409
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:P63000	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q8TD10	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q9UBT7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q6PIF6	Human	PMID:26812018
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q8N8V4	Human	PMID:26812018
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	USH1C	IPI	UniProtKB:Q495M9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	UniProtKB:O75445-1|UniProtKB:Q8BTY2|UniProtKB:Q8WXG9-1|UniProtKB:Q99PJ1	Mouse	MGI:MGI:3619622|PMID:16301216
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	UniProtKB:Q99PJ1|UniProtKB:Q99PF4|UniProtKB:Q99PJ1	Mouse	MGI:MGI:3583725|PMID:15928608
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	UniProtKB:Q2QI47	Mouse	MGI:MGI:5430895|PMID:16301217
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:Q80T11	Mouse	PMID:15590703
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:P97479	Mouse	PMID:12485990
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:Q99PJ1	Mouse	PMID:15590703
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:P97479	Mouse	PMID:15590703
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:Q8K3X6	Mouse	PMID:15461667
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:Q99PJ1	Mouse	PMID:16481439
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:Q99PF4	Mouse	PMID:12485990
Molecular Function	GO:0005515	protein binding	Ush1c	IPI	PR:Q99PF4	Mouse	PMID:15590703
Molecular Function	GO:0005515	protein binding	ush1c	IPI	UniProtKB:Q6QQE1	Zfish	PMID:24626987|ZFIN:ZDB-PUB-140513-359
Molecular Function	GO:0030507	spectrin binding	USH1C	IDA		Human	PMID:23704327
Cellular Component	GO:0045177	apical part of cell	USH1C	IDA		Human	PMID:10209257
Cellular Component	GO:0005903	brush border	USH1C	IDA		Human	PMID:21330445
Cellular Component	GO:0005903	brush border	USH1C	IDA		Human	PMID:24725409
Cellular Component	GO:0005903	brush border	Ush1c	IDA		Mouse	MGI:MGI:5578666|PMID:24725409
Cellular Component	GO:0005903	brush border	Ush1c	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0005737	cytoplasm	USH1C	IDA		Human	PMID:10209257
Cellular Component	GO:0005829	cytosol	USH1C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005902	microvillus	USH1C	IDA		Human	PMID:24725409
Cellular Component	GO:0005902	microvillus	Ush1c	IDA		Mouse	MGI:MGI:5578666|PMID:24725409
Cellular Component	GO:0001917	photoreceptor inner segment	Ush1c	IDA		Mouse	PMID:14578428
Cellular Component	GO:0001917	photoreceptor inner segment	Ush1c	IDA		Mouse	PMID:17906286
Cellular Component	GO:0001917	photoreceptor inner segment	Ush1c	IDA		Rat	PMID:14578428|RGD:1303964
Cellular Component	GO:0001750	photoreceptor outer segment	Ush1c	IDA		Mouse	PMID:14578428
Cellular Component	GO:0001750	photoreceptor outer segment	Ush1c	IDA		Mouse	PMID:17906286
Cellular Component	GO:0001750	photoreceptor outer segment	Ush1c	IDA		Rat	PMID:14578428|RGD:1303964
Cellular Component	GO:0005886	plasma membrane	Ush1c	IDA		Mouse	PMID:15461667
Cellular Component	GO:0005886	plasma membrane	Ush1c	IDA		Rat	PMID:16301216|RGD:8548636
Cellular Component	GO:0032420	stereocilium	Ush1c	EXP		Mouse	PMID:26754646
Cellular Component	GO:0032420	stereocilium	Ush1c	IDA		Mouse	PMID:12485990
Cellular Component	GO:0032420	stereocilium	Ush1c	IDA		Mouse	PMID:20016102
Cellular Component	GO:0032420	stereocilium	Ush1c	IDA		Rat	PMID:16301216|RGD:8548636
Cellular Component	GO:0045202	synapse	Ush1c	IDA		Mouse	PMID:14578428
Cellular Component	GO:0045202	synapse	Ush1c	IDA		Rat	PMID:14578428|RGD:1303964
Cellular Component	GO:0045202	synapse	Ush1c	IDA		Rat	PMID:16301216|RGD:8548636
Cellular Component	GO:1990435	upper tip-link density	Ush1c	IDA		Mouse	PMID:31448880
Biological Process	GO:0051017	actin filament bundle assembly	Ush1c	IDA		Mouse	PMID:12485990
Biological Process	GO:0002093	auditory receptor cell morphogenesis	ush1c	IMP	ZFIN:ZDB-GENO-200123-4	Zfish	PMID:30380418
Biological Process	GO:1904970	brush border assembly	USH1C	IMP		Human	PMID:24725409
Biological Process	GO:1904970	brush border assembly	Ush1c	IMP		Mouse	MGI:MGI:5578666|PMID:24725409
Biological Process	GO:0050957	equilibrioception	USH1C	IMP		Human	PMID:10973247
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	USH1C	IMP		Human	PMID:15219944
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Ush1c	IMP	MGI:MGI:2651859	Mouse	PMID:14519688
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Ush1c	IMP	MGI:MGI:2651858	Mouse	PMID:14519688
Biological Process	GO:0042472	inner ear morphogenesis	Ush1c	IMP	MGI:MGI:2651859	Mouse	PMID:14519688
Biological Process	GO:0042472	inner ear morphogenesis	Ush1c	IMP	MGI:MGI:2651858	Mouse	PMID:14519688
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Ush1c	IMP	MGI:MGI:3757683	Mouse	PMID:18339676
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	ush1c	IMP		Zfish	PMID:24626987
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	ush1c	IMP	ZFIN:ZDB-GENO-120126-4	Zfish	PMID:21757509
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	ush1c	IMP	ZFIN:ZDB-MRPHLNO-111222-1	Zfish	PMID:21757509
Biological Process	GO:0050885	neuromuscular process controlling balance	Ush1c	IMP	MGI:MGI:2651858	Mouse	PMID:14519688
Biological Process	GO:0050885	neuromuscular process controlling balance	Ush1c	IMP	MGI:MGI:2651859	Mouse	PMID:14519688
Biological Process	GO:0030046	parallel actin filament bundle assembly	Ush1c	IDA		Mouse	PMID:12485990
Biological Process	GO:0045494	photoreceptor cell maintenance	USH1C	IMP		Human	PMID:11398101
Biological Process	GO:1904106	protein localization to microvillus	USH1C	IMP		Human	PMID:24725409
Biological Process	GO:1904106	protein localization to microvillus	USH1C	IMP		Human	PMID:26812018
Biological Process	GO:1904106	protein localization to microvillus	Ush1c	IMP		Mouse	MGI:MGI:5578666|PMID:24725409
Biological Process	GO:0065003	protein-containing complex assembly	USH1C	IDA		Human	PMID:26812018
Biological Process	GO:0032532	regulation of microvillus length	Ush1c	IMP		Mouse	MGI:MGI:5578666|PMID:24725409
Biological Process	GO:0046549	retinal cone cell development	ush1c	IMP	ZFIN:ZDB-GENO-120126-4	Zfish	PMID:21757509
Biological Process	GO:0046549	retinal cone cell development	ush1c	IMP	ZFIN:ZDB-MRPHLNO-111222-1	Zfish	PMID:21757509
Biological Process	GO:0050953	sensory perception of light stimulus	USH1C	IMP		Human	PMID:11398101
Biological Process	GO:0007605	sensory perception of sound	USH1C	IMP		Human	PMID:11398101
Biological Process	GO:0007605	sensory perception of sound	Ush1c	IMP	MGI:MGI:2651858	Mouse	PMID:14519688
Biological Process	GO:0007605	sensory perception of sound	Ush1c	IMP	MGI:MGI:2651859	Mouse	PMID:14519688
Biological Process	GO:0001964	startle response	ush1c	IMP	ZFIN:ZDB-GENO-120126-4	Zfish	PMID:21757509
Biological Process	GO:0001964	startle response	ush1c	IMP	ZFIN:ZDB-MRPHLNO-111222-1	Zfish	PMID:21757509
Biological Process	GO:0050808	synapse organization	ush1c	IMP	ZFIN:ZDB-MRPHLNO-111222-1	Zfish	PMID:21757509
Biological Process	GO:0050808	synapse organization	ush1c	IMP	ZFIN:ZDB-GENO-120126-4	Zfish	PMID:21757509

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern