Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USH2A
  • Mouse genes Ush2a
  • Rat genes Ush2a
  • Zfish genes ush2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ush2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	USH2A	IDA		Human	PMID:14676276
Molecular Function	GO:0005518	collagen binding	Ush2a	IDA		Mouse	PMID:14676276
Molecular Function	GO:0042802	identical protein binding	Ush2a	IPI	PR:Q2QI47	Mouse	PMID:25406310
Molecular Function	GO:0017022	myosin binding	Ush2a	IPI	PR:P97479	Mouse	PMID:17567809
Molecular Function	GO:0005515	protein binding	USH2A	IPI	UniProtKB:Q9P202	Human	PMID:16434480
Molecular Function	GO:0005515	protein binding	USH2A	IPI	UniProtKB:Q9H5P4	Human	PMID:20440071
Molecular Function	GO:0005515	protein binding	Ush2a	IPI	UniProtKB:Q80VW5,UniProtKB:Q8VHN7	Mouse	MGI:MGI:4454934|PMID:20502675
Molecular Function	GO:0005515	protein binding	Ush2a	IPI	UniProtKB:E9Q9W7|UniProtKB:Q80VW5	Mouse	MGI:MGI:6214629|PMID:23055499
Molecular Function	GO:0005515	protein binding	Ush2a	IPI	PR:Q80VW5	Mouse	PMID:25406310
Molecular Function	GO:0005515	protein binding	Ush2a	IPI	PR:Q3ZK22	Mouse	PMID:17567809
Cellular Component	GO:0016324	apical plasma membrane	Ush2a	IDA		Mouse	PMID:17360538
Cellular Component	GO:0005604	basement membrane	USH2A	IDA		Human	PMID:12433396
Cellular Component	GO:0005604	basement membrane	Ush2a	IDA		Mouse	PMID:14676276
Cellular Component	GO:0036064	ciliary basal body	Ush2a	IDA		Mouse	PMID:17906286
Cellular Component	GO:0005737	cytoplasm	USH2A	IDA		Human	PMID:16434480
Cellular Component	GO:0043025	neuronal cell body	Ush2a	IDA		Rat	PMID:16434480|RGD:1600128
Cellular Component	GO:1990075	periciliary membrane compartment	Ush2a	IDA		Mouse	MGI:MGI:4454934|PMID:20502675
Cellular Component	GO:1990075	periciliary membrane compartment	Ush2a	IDA		Mouse	PMID:24334608
Cellular Component	GO:1990075	periciliary membrane compartment	Ush2a	IDA		Mouse	PMID:21212183
Cellular Component	GO:0032391	photoreceptor connecting cilium	Ush2a	IDA		Mouse	PMID:21212183
Cellular Component	GO:0032391	photoreceptor connecting cilium	Ush2a	IDA		Mouse	PMID:17906286
Cellular Component	GO:0032391	photoreceptor connecting cilium	Ush2a	IDA		Rat	PMID:16434480|RGD:1600128
Cellular Component	GO:0001917	photoreceptor inner segment	Ush2a	IDA		Mouse	PMID:21212183
Cellular Component	GO:0001917	photoreceptor inner segment	Ush2a	IDA		Rat	PMID:16434480|RGD:1600128
Cellular Component	GO:0002141	stereocilia ankle link	Ush2a	IDA		Mouse	MGI:MGI:5698752|PMID:26401052
Cellular Component	GO:0002141	stereocilia ankle link	Ush2a	IDA		Mouse	MGI:MGI:4454934|PMID:20502675
Cellular Component	GO:0002141	stereocilia ankle link	Ush2a	IDA		Mouse	PMID:24334608
Cellular Component	GO:0002142	stereocilia ankle link complex	Ush2a	IDA		Mouse	PMID:17567809
Cellular Component	GO:0032420	stereocilium	Ush2a	IDA		Rat	PMID:16301216|RGD:8548636
Cellular Component	GO:0032421	stereocilium bundle	Ush2a	IDA		Mouse	PMID:17360538
Cellular Component	GO:0060171	stereocilium membrane	Ush2a	IDA		Mouse	MGI:MGI:5430895|PMID:16301217
Cellular Component	GO:0045202	synapse	Ush2a	IDA		Rat	PMID:16301216|RGD:8548636
Cellular Component	GO:0043195	terminal bouton	Ush2a	IDA		Rat	PMID:16434480|RGD:1600128
Cellular Component	GO:1990696	USH2 complex	Ush2a	IPI		Mouse	MGI:MGI:5618171|PMID:25406310
Cellular Component	GO:1990696	USH2 complex	Ush2a	IDA		Mouse	MGI:MGI:4454934|PMID:20502675
Cellular Component	GO:1990696	USH2 complex	Ush2a	IDA		Mouse	PMID:25406310
Biological Process	GO:0051649	establishment of localization in cell	Ush2a	IMP	MGI:MGI:3702040	Mouse	PMID:24334608
Biological Process	GO:0045184	establishment of protein localization	Ush2a	IMP	MGI:MGI:3702040	Mouse	PMID:24334608
Biological Process	GO:0042462	eye photoreceptor cell development	ush2a	IGI	ZFIN:ZDB-MRPHLNO-100617-4,ZFIN:ZDB-MRPHLNO-100624-9	Zfish	PMID:20440071
Biological Process	GO:0035315	hair cell differentiation	Ush2a	IEP		Mouse	MGI:MGI:5430895|PMID:16301217
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Ush2a	IMP	MGI:MGI:3702040	Mouse	PMID:17360538
Biological Process	GO:0048839	inner ear development	ush2a	IMP	ZFIN:ZDB-GENO-220707-5	Zfish	PMID:31998945
Biological Process	GO:0048496	maintenance of animal organ identity	USH2A	IMP		Human	PMID:15671307
Biological Process	GO:0045494	photoreceptor cell maintenance	USH2A	IMP		Human	PMID:10090909
Biological Process	GO:0045494	photoreceptor cell maintenance	Ush2a	IMP	MGI:MGI:3702040	Mouse	PMID:17360538
Biological Process	GO:0007603	phototransduction, visible light	ush2a	IMP	ZFIN:ZDB-GENO-221012-1	Zfish	PMID:33895329
Biological Process	GO:0010506	regulation of autophagy	ush2a	IMP	ZFIN:ZDB-GENO-220707-6	Zfish	PMID:31998945
Biological Process	GO:0010996	response to auditory stimulus	ush2a	IMP	ZFIN:ZDB-GENO-190419-1	Zfish	PMID:30242501
Biological Process	GO:0060041	retina development in camera-type eye	Ush2a	IEP		Rat	PMID:12160733|RGD:634438
Biological Process	GO:0046549	retinal cone cell development	ush2a	IMP	ZFIN:ZDB-GENO-220707-5	Zfish	PMID:31998945
Biological Process	GO:0046549	retinal cone cell development	ush2a	IMP	ZFIN:ZDB-GENO-220707-6	Zfish	PMID:31998945
Biological Process	GO:0046548	retinal rod cell development	ush2a	IMP	ZFIN:ZDB-GENO-220707-5	Zfish	PMID:31998945
Biological Process	GO:0046548	retinal rod cell development	ush2a	IMP	ZFIN:ZDB-GENO-220707-6	Zfish	PMID:31998945
Biological Process	GO:0050953	sensory perception of light stimulus	USH2A	IMP		Human	PMID:10090909
Biological Process	GO:0050953	sensory perception of light stimulus	ush2a	IMP	ZFIN:ZDB-GENO-190419-1	Zfish	PMID:30242501
Biological Process	GO:0007605	sensory perception of sound	USH2A	IMP		Human	PMID:10090909
Biological Process	GO:0007601	visual perception	ush2a	IMP	ZFIN:ZDB-GENO-230105-5	Zfish	PMID:35672333
Biological Process	GO:0007601	visual perception	ush2a	IMP	ZFIN:ZDB-GENO-221012-1	Zfish	PMID:35672333

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern