Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USP18,USP41
  • Mouse genes Usp18
  • Rat genes Usp18
  • Zfish genes usp18
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Usp18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019785	ISG15-specific peptidase activity	USP18	EXP		Human	PMID:11788588
Molecular Function	GO:0019785	ISG15-specific peptidase activity	Usp18	IMP	MGI:MGI:2387336	Mouse	PMID:16382139
Molecular Function	GO:0019785	ISG15-specific peptidase activity	Usp18	IMP	MGI:MGI:2387336	Mouse	PMID:16139798
Molecular Function	GO:0060090	molecular adaptor activity	USP18	IDA		Human	PMID:27801882
Molecular Function	GO:0005515	protein binding	USP41	IPI	UniProtKB:Q9UMW8	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	USP41	IPI	UniProtKB:Q9UMW8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P05161	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P48551	Human	PMID:16710296
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:Q3LFD5	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P05161	Human	PMID:25307056
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P05161	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P48551	Human	PMID:28165510
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P52630	Human	PMID:28165510
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:Q3LFD5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P05161	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P52630	Human	PMID:31836668
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P52630	Human	PMID:32092142
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P05161	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	USP18	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Usp18	IPI	UniProtKB:Q64339	Mouse	MGI:MGI:5558960|PMID:24533902
Molecular Function	GO:0005515	protein binding	Usp18	IPI	UniProtKB:Q64339	Mouse	MGI:MGI:6695688|PMID:32726803
Molecular Function	GO:0032182	ubiquitin-like protein binding	usp18	IPI	GenPept:NP_056598.2	Zfish	PMID:28165509
Cellular Component	GO:0005829	cytosol	USP18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	USP18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	USP18	IDA		Human	GO_REF:0000054
Biological Process	GO:0140374	antiviral innate immune response	USP18	IDA		Human	PMID:27801882
Biological Process	GO:1904888	cranial skeletal system development	usp18	IMP	ZFIN:ZDB-MRPHLNO-100217-11	Zfish	PMID:28450118
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	USP18	IDA		Human	PMID:28165510
Biological Process	GO:0050727	regulation of inflammatory response	USP18	IMP		Human	PMID:27325888
Biological Process	GO:0009617	response to bacterium	Usp18	IEP		Mouse	PMID:23012479
Biological Process	GO:0035634	response to stilbenoid	Usp18	IEP		Mouse	MGI:MGI:4943399|PMID:17086191

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern