Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USP19
  • Mouse genes Usp19
  • Rat genes Usp19
  • Zfish genes usp19
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Usp19

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP19	IDA		Human	PMID:19465887
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP19	IMP		Human	PMID:24356957
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Usp19	IMP		Mouse	MGI:MGI:5315325|PMID:21971047
Molecular Function	GO:0051879	Hsp90 protein binding	USP19	IDA		Human	PMID:24356957
Molecular Function	GO:1990380	K48-linked deubiquitinase activity	Usp19	IDA		Mouse	MGI:MGI:5614537|PMID:25088257
Molecular Function	GO:0005515	protein binding	USP19	IPI	UniProtKB:P98170	Human	PMID:21849505
Molecular Function	GO:0005515	protein binding	USP19	IPI	UniProtKB:Q13489	Human	PMID:21849505
Molecular Function	GO:0005515	protein binding	USP19	IPI	UniProtKB:Q13490	Human	PMID:21849505
Molecular Function	GO:0005515	protein binding	USP19	IPI	UniProtKB:Q16665	Human	PMID:22128162
Molecular Function	GO:0005515	protein binding	Usp19	IPI	UniProtKB:O75344	Mouse	MGI:MGI:5586943|PMID:25036637
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Usp19	IPI	UniProtKB:O60337	Mouse	MGI:MGI:5614537|PMID:25088257
Cellular Component	GO:0005829	cytosol	USP19	IDA		Human	PMID:24356957
Cellular Component	GO:0005829	cytosol	Usp19	IDA		Mouse	MGI:MGI:3831629|PMID:19015242
Cellular Component	GO:0005789	endoplasmic reticulum membrane	USP19	IDA		Human	PMID:19465887
Biological Process	GO:0021551	central nervous system morphogenesis	usp19	IMP	ZFIN:ZDB-MRPHLNO-100217-12	Zfish	PMID:20040115
Biological Process	GO:1901799	negative regulation of proteasomal protein catabolic process	Usp19	IDA		Mouse	MGI:MGI:5614537|PMID:25088257
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	Usp19	IMP		Mouse	MGI:MGI:5315325|PMID:21971047
Biological Process	GO:0090068	positive regulation of cell cycle process	Usp19	IMP		Rat	PMID:19015242|RGD:8554198
Biological Process	GO:0016579	protein deubiquitination	USP19	IMP		Human	PMID:24356957
Biological Process	GO:0016579	protein deubiquitination	Usp19	IMP		Rat	PMID:15562254|RGD:8554323
Biological Process	GO:0071108	protein K48-linked deubiquitination	Usp19	IDA		Mouse	MGI:MGI:5614537|PMID:25088257
Biological Process	GO:0050821	protein stabilization	USP19	IMP		Human	PMID:25088257
Biological Process	GO:0050821	protein stabilization	Usp19	IDA		Mouse	MGI:MGI:5614537|PMID:25088257
Biological Process	GO:1900037	regulation of cellular response to hypoxia	USP19	IMP		Human	PMID:22128162
Biological Process	GO:1904292	regulation of ERAD pathway	USP19	IMP		Human	PMID:25088257
Biological Process	GO:0031647	regulation of protein stability	Usp19	IDA		Rat	PMID:19015242|RGD:8554198
Biological Process	GO:0034976	response to endoplasmic reticulum stress	USP19	IEP		Human	PMID:19465887
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	USP19	IDA		Human	PMID:19465887

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern