Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USP28
  • Mouse genes Usp28
  • Rat genes Usp28
  • Zfish genes usp28
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Usp28

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP28	IDA		Human	PMID:16901786
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP28	IMP		Human	PMID:16901786
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP28	IDA		Human	PMID:17558397
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP28	IMP		Human	PMID:17558397
Molecular Function	GO:0101005	deubiquitinase activity	USP28	IMP		Human	PMID:24623306
Molecular Function	GO:0005515	protein binding	USP28	IPI	UniProtKB:Q12888	Human	PMID:16901786
Molecular Function	GO:0005515	protein binding	USP28	IPI	UniProtKB:Q969H0-1	Human	PMID:17558397
Molecular Function	GO:0005515	protein binding	USP28	IPI	UniProtKB:P01106	Human	PMID:17873522
Molecular Function	GO:0005515	protein binding	USP28	IPI	UniProtKB:Q15139	Human	PMID:24623306
Molecular Function	GO:0005515	protein binding	USP28	IPI	UniProtKB:Q9HCX3	Human	PMID:24623306
Cellular Component	GO:0016604	nuclear body	USP28	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	USP28	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	USP28	IDA		Human	PMID:17558397
Cellular Component	GO:0032991	protein-containing complex	USP28	IDA		Human	PMID:17873522
Biological Process	GO:0008283	cell population proliferation	USP28	IMP		Human	PMID:17558397
Biological Process	GO:0034644	cellular response to UV	USP28	IDA		Human	PMID:17873522
Biological Process	GO:0021551	central nervous system morphogenesis	usp28	IMP	ZFIN:ZDB-MRPHLNO-100217-19	Zfish	PMID:20040115
Biological Process	GO:0000077	DNA damage checkpoint signaling	USP28	IMP		Human	PMID:18662541
Biological Process	GO:0006974	DNA damage response	USP28	IDA		Human	PMID:17873522
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	USP28	IDA		Human	PMID:16901786
Biological Process	GO:0016579	protein deubiquitination	USP28	IDA		Human	PMID:16901786
Biological Process	GO:0016579	protein deubiquitination	USP28	IDA		Human	PMID:17558397
Biological Process	GO:0016579	protein deubiquitination	USP28	IDA		Human	PMID:18662541
Biological Process	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	USP28	IMP		Human	PMID:24623306
Biological Process	GO:0031647	regulation of protein stability	USP28	IMP		Human	PMID:24623306
Biological Process	GO:0010212	response to ionizing radiation	USP28	IDA		Human	PMID:16901786

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern