Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USP8
  • Mouse genes Usp8
  • Rat genes Usp8
  • Zfish genes usp8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Usp8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	USP8	HDA		Human	PMID:25468996
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP8	IDA		Human	PMID:16520378
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP8	IDA		Human	PMID:18388320
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP8	IDA		Human	PMID:18728397
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP8	IDA		Human	PMID:27444016
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Usp8	IDA		Mouse	MGI:MGI:3620312|PMID:16120644
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Usp8	IDA		Mouse	MGI:MGI:4821940|PMID:16771824
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Usp8	IDA		Mouse	PMID:15342353
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Usp8	IDA		Mouse	PMID:11500497
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q7LBR1	Human	PMID:17711858
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q96CF2	Human	PMID:17711858
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q9HD42	Human	PMID:17711858
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q9NR09	Human	PMID:18329369
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q7LBR1	Human	PMID:19302785
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q96CF2	Human	PMID:19302785
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q9HD42	Human	PMID:19302785
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q14596	Human	PMID:19427866
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q16665	Human	PMID:24378640
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:Q99814	Human	PMID:24378640
Molecular Function	GO:0005515	protein binding	USP8	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Usp8	IPI	UniProtKB:P42567	Mouse	MGI:MGI:4821940|PMID:16771824
Molecular Function	GO:0005515	protein binding	Usp8	IPI	UniProtKB:Q01279	Mouse	MGI:MGI:3620312|PMID:16120644
Molecular Function	GO:0005515	protein binding	Usp8	IPI	UniProtKB:Q8BH75|UniProtKB:Q9H4P4	Mouse	MGI:MGI:3054509|PMID:15314180
Molecular Function	GO:0005515	protein binding	Usp8	IPI	PR:Q60631	Mouse	PMID:10982817
Molecular Function	GO:0005515	protein binding	Usp8	IPI	PR:P70297	Mouse	PMID:10982817
Molecular Function	GO:0005515	protein binding	Usp8	IPI	PR:O35723	Mouse	PMID:15342353
Molecular Function	GO:0005515	protein binding	Usp8	IPI	PR:O88811	Mouse	PMID:10982817
Cellular Component	GO:0002080	acrosomal membrane	Usp8	IDA		Mouse	PMID:15342353
Cellular Component	GO:0005737	cytoplasm	USP8	IDA		Human	PMID:18388320
Cellular Component	GO:0005829	cytosol	USP8	IDA		Human	PMID:16520378
Cellular Component	GO:0005829	cytosol	USP8	IDA		Human	PMID:27444016
Cellular Component	GO:0005829	cytosol	Usp8	IDA		Mouse	MGI:MGI:3620312|PMID:16120644
Cellular Component	GO:0005829	cytosol	Usp8	IDA		Rat	PMID:25662281|RGD:11053004
Cellular Component	GO:0043197	dendritic spine	Usp8	IDA		Rat	PMID:25505317|RGD:11076799
Cellular Component	GO:0005769	early endosome	USP8	IDA		Human	PMID:16520378
Cellular Component	GO:0005769	early endosome	Usp8	IDA		Rat	PMID:25662281|RGD:11053004
Cellular Component	GO:0031313	extrinsic component of endosome membrane	Usp8	IDA		Mouse	MGI:MGI:3620312|PMID:16120644
Cellular Component	GO:0019897	extrinsic component of plasma membrane	USP8	IDA		Human	PMID:16520378
Cellular Component	GO:0098978	glutamatergic synapse	Usp8	IDA		Rat	PMID:25505317|RGD:11076799
Cellular Component	GO:0098978	glutamatergic synapse	Usp8	IMP		Rat	PMID:25505317|RGD:11076799
Cellular Component	GO:0005622	intracellular anatomical structure	Usp8	IDA		Mouse	PMID:11500497
Cellular Component	GO:0030496	midbody	USP8	IDA		Human	PMID:18388320
Cellular Component	GO:0030496	midbody	Usp8	IDA		Mouse	PMID:18388320
Cellular Component	GO:0014069	postsynaptic density	Usp8	IDA		Rat	PMID:25505317|RGD:11076799
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Usp8	IEP		Rat	PMID:19527720|RGD:13208949
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Usp8	IDA		Rat	PMID:25662281|RGD:11053004
Biological Process	GO:0007032	endosome organization	USP8	IMP		Human	PMID:16520378
Biological Process	GO:0007032	endosome organization	Usp8	IMP		Mouse	MGI:MGI:4821940|PMID:16771824
Biological Process	GO:0000281	mitotic cytokinesis	USP8	IMP		Human	PMID:18388320
Biological Process	GO:1905166	negative regulation of lysosomal protein catabolic process	USP8	IMP		Human	PMID:27444016
Biological Process	GO:1905908	positive regulation of amyloid fibril formation	USP8	IMP		Human	PMID:27444016
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	USP8	IMP		Human	PMID:20495530
Biological Process	GO:0016579	protein deubiquitination	USP8	IMP		Human	PMID:18388320
Biological Process	GO:0016579	protein deubiquitination	USP8	IMP		Human	PMID:27302062
Biological Process	GO:0016579	protein deubiquitination	Usp8	IMP		Mouse	MGI:MGI:3054509|PMID:15314180
Biological Process	GO:0016579	protein deubiquitination	Usp8	IDA		Mouse	MGI:MGI:3620312|PMID:16120644
Biological Process	GO:0016579	protein deubiquitination	Usp8	IDA		Mouse	MGI:MGI:4821940|PMID:16771824
Biological Process	GO:0016579	protein deubiquitination	Usp8	IDA		Mouse	PMID:15342353
Biological Process	GO:0071108	protein K48-linked deubiquitination	USP8	IDA		Human	PMID:16520378
Biological Process	GO:0070536	protein K63-linked deubiquitination	USP8	IDA		Human	PMID:16520378
Biological Process	GO:0007265	Ras protein signal transduction	Usp8	IPI	PR:P48967	Mouse	PMID:11500497
Biological Process	GO:1902017	regulation of cilium assembly	usp8	IMP	ZFIN:ZDB-CRISPR-180925-3	Zfish	PMID:29472535
Biological Process	GO:1902017	regulation of cilium assembly	usp8	IMP	ZFIN:ZDB-CRISPR-180925-2	Zfish	PMID:29472535
Biological Process	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	Usp8	IDA		Rat	PMID:25505317|RGD:11076799
Biological Process	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	Usp8	IEP		Rat	PMID:25505317|RGD:11076799
Biological Process	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	Usp8	IMP		Rat	PMID:25505317|RGD:11076799
Biological Process	GO:0032880	regulation of protein localization	USP8	IMP		Human	PMID:27302062
Biological Process	GO:0031647	regulation of protein stability	USP8	IMP		Human	PMID:27302062

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern