Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAMP8
  • Mouse genes Vamp8
  • Rat genes Vamp8
  • Zfish genes vamp8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vamp8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019869	chloride channel inhibitor activity	VAMP8	IDA		Human	PMID:18570918
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:O15400	Human	PMID:19557002
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:Q13492	Human	PMID:22118466
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:O95721	Human	PMID:23217709
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:P56962	Human	PMID:23217709
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:O95721	Human	PMID:25419848
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:P56962	Human	PMID:25419848
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:P56962	Human	PMID:31806350
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:O15400	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:P56962	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	VAMP8	IPI	UniProtKB:O95721	Human	PMID:33947832
Molecular Function	GO:0005515	protein binding	Vamp8	IPI	UniProtKB:O55012	Mouse	MGI:MGI:5315673|PMID:22118466
Molecular Function	GO:0005515	protein binding	Vamp8	IPI	PR:Q8R307	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vamp8	IPI	RGD:1311556	Rat	PMID:14668490|RGD:1549677
Molecular Function	GO:0005484	SNAP receptor activity	Vamp8	IDA		Rat	PMID:15133481|RGD:4892614
Molecular Function	GO:0005484	SNAP receptor activity	Vamp8	IDA		Rat	PMID:19109692|RGD:2306549
Molecular Function	GO:0019905	syntaxin binding	Vamp8	IPI	RGD:619747	Rat	PMID:15133481|RGD:4892614
Cellular Component	GO:0035577	azurophil granule membrane	VAMP8	IDA		Human	PMID:16677249
Cellular Component	GO:0045178	basal part of cell	Vamp8	IDA		Mouse	PMID:18535671
Cellular Component	GO:1990794	basolateral part of cell	Vamp8	IDA		Mouse	PMID:18535671
Cellular Component	GO:0016323	basolateral plasma membrane	Vamp8	IDA		Mouse	PMID:18535671
Cellular Component	GO:0009986	cell surface	Vamp8	IDA		Mouse	MGI:MGI:5567905|PMID:21151919
Cellular Component	GO:0005737	cytoplasm	VAMP8	IDA		Human	PMID:18253931
Cellular Component	GO:0005829	cytosol	VAMP8	IDA		Human	PMID:22589474
Cellular Component	GO:0005829	cytosol	Vamp8	IDA		Mouse	MGI:MGI:5444087|PMID:22589474
Cellular Component	GO:0070062	extracellular exosome	VAMP8	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	VAMP8	HDA		Human	PMID:20458337
Cellular Component	GO:0031902	late endosome membrane	VAMP8	IDA		Human	PMID:23217709
Cellular Component	GO:0031902	late endosome membrane	Vamp8	IDA		Rat	PMID:15133481|RGD:4892614
Cellular Component	GO:0005765	lysosomal membrane	VAMP8	IDA		Human	PMID:23217709
Cellular Component	GO:0005765	lysosomal membrane	Vamp8	IDA		Rat	PMID:15133481|RGD:4892614
Cellular Component	GO:0005764	lysosome	Vamp8	IDA		Mouse	MGI:MGI:5805578|PMID:27628032
Cellular Component	GO:0016020	membrane	VAMP8	IDA		Human	PMID:16677249
Cellular Component	GO:0030496	midbody	Vamp8	IDA		Rat	PMID:12737809|RGD:1298908
Cellular Component	GO:0005739	mitochondrion	Vamp8	HDA		Mouse	PMID:18614015
Cellular Component	GO:0098594	mucin granule	VAMP8	IDA		Human	PMID:22144578
Cellular Component	GO:0048471	perinuclear region of cytoplasm	VAMP8	IDA		Human	PMID:18570918
Cellular Component	GO:0045335	phagocytic vesicle	Vamp8	IDA		Mouse	PMID:19144319
Cellular Component	GO:0005886	plasma membrane	VAMP8	IDA		Human	PMID:18253931
Cellular Component	GO:0055037	recycling endosome	VAMP8	IDA		Human	PMID:18570918
Cellular Component	GO:0055037	recycling endosome	Vamp8	IDA		Rat	PMID:10468577|RGD:4892345
Cellular Component	GO:0030141	secretory granule	Vamp8	IDA		Mouse	PMID:18321981
Cellular Component	GO:0030667	secretory granule membrane	VAMP8	IDA		Human	PMID:16677249
Cellular Component	GO:0031201	SNARE complex	VAMP8	IDA		Human	PMID:12130530
Cellular Component	GO:0031201	SNARE complex	VAMP8	IDA		Human	PMID:18253931
Cellular Component	GO:0031201	SNARE complex	VAMP8	IDA		Human	PMID:23217709
Cellular Component	GO:0031201	SNARE complex	VAMP8	IDA		Human	PMID:24550300
Cellular Component	GO:0031201	SNARE complex	Vamp8	IDA		Mouse	PMID:18535671
Cellular Component	GO:0031201	SNARE complex	Vamp8	IDA		Rat	PMID:11786915|RGD:634188
Cellular Component	GO:0031201	SNARE complex	Vamp8	IDA		Rat	PMID:19109692|RGD:2306549
Cellular Component	GO:0031982	vesicle	VAMP8	IDA		Human	PMID:18570918
Cellular Component	GO:0042588	zymogen granule	Vamp8	IDA		Mouse	PMID:18535671
Biological Process	GO:0097352	autophagosome maturation	VAMP8	IMP		Human	PMID:23217709
Biological Process	GO:0016240	autophagosome membrane docking	VAMP8	IDA		Human	PMID:25686604
Biological Process	GO:0071346	cellular response to type II interferon	Vamp8	IDA		Mouse	PMID:19144319
Biological Process	GO:0051649	establishment of localization in cell	Vamp8	IMP	MGI:MGI:3056083	Mouse	PMID:18535671
Biological Process	GO:0061025	membrane fusion	Vamp8	IDA		Rat	PMID:19109692|RGD:2306549
Biological Process	GO:0070254	mucus secretion	VAMP8	IMP		Human	PMID:22144578
Biological Process	GO:0070254	mucus secretion	Vamp8	IMP		Mouse	MGI:MGI:5484853|PMID:22144578
Biological Process	GO:1903531	negative regulation of secretion by cell	VAMP8	IDA		Human	PMID:12130530
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	VAMP8	IMP		Human	PMID:18253931
Biological Process	GO:1902278	positive regulation of pancreatic amylase secretion	Vamp8	IMP	MGI:MGI:3056083	Mouse	PMID:18535671
Biological Process	GO:0065003	protein-containing complex assembly	Vamp8	IDA		Rat	PMID:10336434|RGD:634238
Biological Process	GO:0030100	regulation of endocytosis	Vamp8	IMP		Mouse	PMID:18227281
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	VAMP8	IDA		Human	PMID:18570918
Biological Process	GO:0035493	SNARE complex assembly	Vamp8	IDA		Mouse	MGI:MGI:5567905|PMID:21151919
Biological Process	GO:0006906	vesicle fusion	Vamp8	IMP	MGI:MGI:3056083	Mouse	PMID:18535671
Biological Process	GO:0006906	vesicle fusion	Vamp8	IDA		Rat	PMID:15133481|RGD:4892614
Biological Process	GO:0016192	vesicle-mediated transport	Vamp8	IDA		Rat	PMID:15133481|RGD:4892614
Biological Process	GO:0046718	viral entry into host cell	VAMP8	IMP		Human	PMID:24550300
Biological Process	GO:0070625	zymogen granule exocytosis	Vamp8	IMP	MGI:MGI:3056083	Mouse	PMID:18535671

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern