Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAPA
  • Mouse genes Vapa
  • Rat genes Vapa
  • Zfish genes vapa,vapal
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vapa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	VAPA	HDA		Human	PMID:25468996
Molecular Function	GO:0033149	FFAT motif binding	VAPA	IMP		Human	PMID:18713837
Molecular Function	GO:0042802	identical protein binding	Vapa	IPI	UniProtKB:Q9Z270	Rat	PMID:16004875|RGD:13432356
Molecular Function	GO:0008017	microtubule binding	VAPA	IMP		Human	PMID:18713837
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:10544080
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:10544080
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O95292	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q03463:PRO_0000278740	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q03463:PRO_0000278741	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9Y5P4	Human	PMID:16895911
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:16996479
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9P035	Human	PMID:18160438
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q5T4F4	Human	PMID:19289470
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O95292-1	Human	PMID:19515777
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q03463:PRO_0000278740	Human	PMID:19515777
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q03463:PRO_0000278741	Human	PMID:19515777
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q8WXG1	Human	PMID:21957124
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:21957124
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9WMX2:PRO_0000037552	Human	PMID:21957124
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P33175	Human	PMID:21976701
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q5T4F4	Human	PMID:21976701
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q8WXG1	Human	PMID:22045669
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O95070	Human	PMID:23736259
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P35372	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q99IB8:PRO_0000045602	Human	PMID:23935497
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q14849-1	Human	PMID:24105263
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P22059	Human	PMID:24209621
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q99IB8:PRO_0000045600	Human	PMID:25616068
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q99IB8:PRO_0000045602	Human	PMID:25616068
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P22059	Human	PMID:25681634
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P05090	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O95070	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O95292	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P22059	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P35372	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q14849	Human	PMID:28377464
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9BXW6	Human	PMID:29858488
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P22059	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9HB20	Human	PMID:30659099
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9NTJ5	Human	PMID:30659099
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q96RL7	Human	PMID:30741634
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:A0A024R8A9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O00559	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O15173	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O15209	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O60669	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:O95214	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P05090	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P49447	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P78383	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q06432	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q53FP2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q53TN4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q86VR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q8N5M9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q8NBD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q8NBQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q96K78	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q96LZ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9BY50	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9NS71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P22059	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VAPA	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Vapa	IPI	UniProtKB:Q3TXX3	Mouse	MGI:MGI:5606143|PMID:24251978
Molecular Function	GO:0005515	protein binding	Vapa	IPI	UniProtKB:Q8K4M9	Rat	PMID:16004875|RGD:13432356
Molecular Function	GO:0019904	protein domain specific binding	VAPA	IPI	UniProtKB:P22059	Human	PMID:20178991
Molecular Function	GO:0046982	protein heterodimerization activity	VAPA	IPI	UniProtKB:O95292	Human	PMID:16227268
Molecular Function	GO:0046982	protein heterodimerization activity	VAPA	IPI	UniProtKB:O95292	Human	PMID:9920726
Molecular Function	GO:0044877	protein-containing complex binding	Vapa	IDA		Rat	PMID:9920726|RGD:61779
Cellular Component	GO:0005923	bicellular tight junction	VAPA	IDA		Human	PMID:10523508
Cellular Component	GO:0005783	endoplasmic reticulum	VAPA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	VAPA	HDA		Human	PMID:16791210
Cellular Component	GO:0005783	endoplasmic reticulum	VAPA	IDA		Human	PMID:18713837
Cellular Component	GO:0005783	endoplasmic reticulum	VAPA	IDA		Human	PMID:19289470
Cellular Component	GO:0005783	endoplasmic reticulum	Vapa	IDA		Mouse	PMID:10655491
Cellular Component	GO:0005789	endoplasmic reticulum membrane	VAPA	IDA		Human	PMID:12023275
Cellular Component	GO:0005789	endoplasmic reticulum membrane	VAPA	IDA		Human	PMID:30741634
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Vapa	IDA		Rat	PMID:24262037|RGD:11059584
Cellular Component	GO:0000139	Golgi membrane	VAPA	IDA		Human	PMID:24209621
Cellular Component	GO:0016020	membrane	Vapa	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0015630	microtubule cytoskeleton	Vapa	IDA		Mouse	PMID:10655491
Cellular Component	GO:0031965	nuclear membrane	Vapa	IDA		Rat	PMID:24262037|RGD:11059584
Cellular Component	GO:0048471	perinuclear region of cytoplasm	VAPA	IDA		Human	PMID:16895911
Cellular Component	GO:0005886	plasma membrane	VAPA	IDA		Human	PMID:10523508
Cellular Component	GO:0031982	vesicle	VAPA	IDA		Human	PMID:10523508
Biological Process	GO:0008219	cell death	VAPA	IMP		Human	PMID:19289470
Biological Process	GO:0008219	cell death	Vapa	IMP		Rat	PMID:19289470|RGD:8554038
Biological Process	GO:0035627	ceramide transport	VAPA	IMP		Human	PMID:12023275
Biological Process	GO:0090114	COPII-coated vesicle budding	VAPA	IMP		Human	PMID:18713837
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	VAPA	IMP		Human	PMID:18713837
Biological Process	GO:0044828	negative regulation by host of viral genome replication	VAPA	IDA		Human	PMID:19515777
Biological Process	GO:0031175	neuron projection development	VAPA	IMP		Human	PMID:19289470
Biological Process	GO:0031175	neuron projection development	Vapa	IMP		Rat	PMID:19289470|RGD:8554038
Biological Process	GO:0015914	phospholipid transport	VAPA	IDA		Human	PMID:24209621
Biological Process	GO:0044829	positive regulation by host of viral genome replication	VAPA	IDA		Human	PMID:19515777
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	VAPA	HMP		Human	PMID:12761501
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	VAPA	IMP		Human	PMID:19289470
Biological Process	GO:0008016	regulation of heart contraction	vapa	IMP	ZFIN:ZDB-MRPHLNO-200130-3	Zfish	PMID:29879376
Biological Process	GO:0008016	regulation of heart contraction	vapa	IGI	ZFIN:ZDB-MRPHLNO-130625-1,ZFIN:ZDB-MRPHLNO-200130-3	Zfish	PMID:29879376
Biological Process	GO:0006686	sphingomyelin biosynthetic process	VAPA	IMP		Human	PMID:12023275
Biological Process	GO:0015918	sterol transport	VAPA	IDA		Human	PMID:24209621
Biological Process	GO:0019076	viral release from host cell	VAPA	IDA		Human	PMID:19515777

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern