Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAV1
  • Mouse genes Vav1
  • Rat genes Vav1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vav1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	VAV1	EXP		Human	PMID:8990121
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav1	EXP		Mouse	MGI:MGI:3613346|PMID:15644420
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav1	EXP		Mouse	MGI:MGI:3607660|PMID:16203968
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav1	EXP		Mouse	MGI:MGI:6214787|PMID:17721087
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav1	IGI	MGI:MGI:1888518	Mouse	PMID:15249579
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	Vav1	IPI	UniProtKB:Q9QZE2	Mouse	MGI:MGI:2179131|PMID:10744659
Molecular Function	GO:0001784	phosphotyrosine residue binding	VAV1	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q13094	Human	PMID:10347175
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P03406	Human	PMID:10394361
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P78314	Human	PMID:11390470
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:O43561	Human	PMID:12186560
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P78314	Human	PMID:15345594
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P62993	Human	PMID:15558030
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q8N720	Human	PMID:15558030
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P08487	Human	PMID:16467851
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P78314	Human	PMID:17306257
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q07666	Human	PMID:17855053
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P63000	Human	PMID:18511940
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P62993	Human	PMID:18692475
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P00519	Human	PMID:19234221
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q8IZP0	Human	PMID:20598684
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q13094	Human	PMID:21725281
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:P62993	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q13094	Human	PMID:8673706
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q13094	Human	PMID:9047237
Molecular Function	GO:0005515	protein binding	VAV1	IPI	UniProtKB:Q8WV28	Human	PMID:9697839
Molecular Function	GO:0005515	protein binding	Vav1	IPI	UniProtKB:P19878	Mouse	MGI:MGI:5915720|PMID:22203994
Molecular Function	GO:0005515	protein binding	Vav1	IPI	PR:Q91YX0	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Vav1	IPI	PR:P29351	Mouse	PMID:8632004
Molecular Function	GO:0005515	protein binding	Vav1	IPI	PR:Q8BGW0	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Vav1	IPI	PR:Q91WK7	Mouse	PMID:19064729
Cellular Component	GO:0005911	cell-cell junction	Vav1	IDA		Mouse	PMID:23793062
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Vav1	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Vav1	IGI	MGI:MGI:97845	Mouse	PMID:21178006
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Vav1	IGI	MGI:MGI:97846	Mouse	PMID:21178006
Biological Process	GO:0006955	immune response	Vav1	IMP	MGI:MGI:2387838	Mouse	PMID:11070165
Biological Process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	Vav1	IEP		Rat	PMID:1531699|RGD:2306006
Biological Process	GO:0007229	integrin-mediated signaling pathway	Vav1	IGI	MGI:MGI:1888518	Mouse	PMID:15249579
Biological Process	GO:0035556	intracellular signal transduction	Vav1	IMP	MGI:MGI:2387838	Mouse	PMID:11070165
Biological Process	GO:0030593	neutrophil chemotaxis	Vav1	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0006909	phagocytosis	Vav1	IGI	MGI:MGI:1888518	Mouse	PMID:15249579
Biological Process	GO:0045785	positive regulation of cell adhesion	Vav1	IGI	MGI:MGI:1888518	Mouse	PMID:15249579
Biological Process	GO:0045785	positive regulation of cell adhesion	Vav1	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0043547	positive regulation of GTPase activity	Vav1	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Vav1	IGI	MGI:MGI:3622649	Mouse	PMID:20962259
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Vav1	IGI	MGI:MGI:1349420	Mouse	PMID:20962259
Biological Process	GO:0072593	reactive oxygen species metabolic process	Vav1	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0008361	regulation of cell size	VAV1	IGI	UniProtKB:P35241,UniProtKB:P52735,UniProtKB:Q9UKW4	Human	PMID:22467863
Biological Process	GO:0043087	regulation of GTPase activity	VAV1	IGI	UniProtKB:P35241,UniProtKB:P52735,UniProtKB:Q9UKW4	Human	PMID:22467863
Biological Process	GO:0043087	regulation of GTPase activity	Vav1	IGI	MGI:MGI:1888518	Mouse	PMID:15249579
Biological Process	GO:0042110	T cell activation	Vav1	IMP	MGI:MGI:2387838	Mouse	PMID:11070165
Biological Process	GO:0030217	T cell differentiation	Vav1	IGI	MGI:MGI:3040696	Mouse	PMID:21178006

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern