Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAV3
  • Mouse genes Vav3
  • Rat genes Vav3
  • Zfish genes vav3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vav3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Vav3	IPI	PR:Q01279	Mouse	PMID:15728722
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	VAV3	EXP		Human	PMID:8990121
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav3	IMP		Mouse	PMID:15728722
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav3	IGI	MGI:MGI:98923	Mouse	PMID:15249579
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P62993	Human	PMID:12577067
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P27986	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P62993	Human	PMID:18654987
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:P62993	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:Q13191	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:Q6NUQ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAV3	IPI	UniProtKB:Q9UGI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Vav3	IPI	UniProtKB:Q03145	Mouse	MGI:MGI:3640033|PMID:16782872
Cellular Component	GO:0005737	cytoplasm	Vav3	IDA		Mouse	PMID:15728722
Cellular Component	GO:0001772	immunological synapse	VAV3	IDA		Human	PMID:15708849
Cellular Component	GO:0005886	plasma membrane	Vav3	IDA		Mouse	PMID:15728722
Biological Process	GO:0050853	B cell receptor signaling pathway	VAV3	IMP		Human	PMID:17875758
Biological Process	GO:0016477	cell migration	Vav3	IGI	MGI:MGI:102718	Mouse	PMID:15728722
Biological Process	GO:0030031	cell projection assembly	Vav3	IGI	MGI:MGI:102718	Mouse	PMID:15728722
Biological Process	GO:0006974	DNA damage response	VAV3	IMP		Human	PMID:17875758
Biological Process	GO:0007229	integrin-mediated signaling pathway	Vav3	IGI	MGI:MGI:98923	Mouse	PMID:15249579
Biological Process	GO:0030032	lamellipodium assembly	Vav3	IGI	MGI:MGI:102718	Mouse	PMID:15728722
Biological Process	GO:0030593	neutrophil chemotaxis	Vav3	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0030890	positive regulation of B cell proliferation	VAV3	IMP		Human	PMID:17875758
Biological Process	GO:0045785	positive regulation of cell adhesion	Vav3	IGI	MGI:MGI:98923	Mouse	PMID:15249579
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Vav3	IGI	MGI:MGI:102718	Mouse	PMID:15728722
Biological Process	GO:0008361	regulation of cell size	VAV3	IGI	UniProtKB:P15498,UniProtKB:P35241,UniProtKB:P52735	Human	PMID:22467863
Biological Process	GO:0043087	regulation of GTPase activity	VAV3	IGI	UniProtKB:P15498,UniProtKB:P35241,UniProtKB:P52735	Human	PMID:22467863
Biological Process	GO:0043087	regulation of GTPase activity	Vav3	IGI	MGI:MGI:98923	Mouse	PMID:15249579
Biological Process	GO:0009410	response to xenobiotic stimulus	VAV3	IMP		Human	PMID:17875758
Biological Process	GO:0007264	small GTPase mediated signal transduction	Vav3	IMP		Mouse	PMID:15728722
Biological Process	GO:0006906	vesicle fusion	Vav3	IGI	MGI:MGI:98923	Mouse	PMID:15249579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern